Performance of a quick pregnancy test on whole blood in early pregnancy units: a prospective cohort study

Legoupil, Caroline; Enderle, Isabelle; Baccon, Flore-Anne Le; Bendavid, Claude; Peltier, Lucas; Bauville, Estelle; Lévêque, Jean; Lavoué, Vincent; Lous, Maëla Le

doi:10.1097/mej.0000000000000501

Cited by 2 publications

(2 citation statements)

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“…In the gynecology ED, pregnancy complications require a rapid and accurate diagnostic [ 9 ]. In this context, the TAT of beta-human chorionic gonadotropin (βhCG) result is essential, but limited published data describe the effect of POCT βhCG on ED diagnostics and logistics [ 10 , 11 ]. Legoupil et al [ 10 ] evaluated the performance of a qualitative screening test for βhCG in the whole blood of women consulting in early pregnancy units for vaginal bleeding and/or pelvic pain.…”

Section: Introductionmentioning

confidence: 99%

“…In this context, the TAT of beta-human chorionic gonadotropin (βhCG) result is essential, but limited published data describe the effect of POCT βhCG on ED diagnostics and logistics [ 10 , 11 ]. Legoupil et al [ 10 ] evaluated the performance of a qualitative screening test for βhCG in the whole blood of women consulting in early pregnancy units for vaginal bleeding and/or pelvic pain. Although POCT βhCG reduced the waiting time to the result by approximately 85 min, this study did not assess the improvement in the time spent in early pregnancy units.…”

Section: Introductionmentioning

confidence: 99%

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Optimization of Patient Management in the Gynecology Emergency Department Using Point-of-Care Beta hCG

et al. 2022

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Background: Point-of-care testing (POCT) provides shorter turn-around times and, in many cases, potentially improves medical decision making. The AQT90 FLEX® benchtop immunoanalyzer (Radiometer Medical ApS, Copenhagen, Denmark) allows for the determination of beta-human chorionic gonadotropin (βhCG) in 18 min. The main aim of this study was to evaluate the impact of measuring βhCG using the AQT90 analyzer in the gynecology emergency department (ED) compared to the standard practice of using central laboratory blood testing on the patient length of stay (LOS). Methods: The evaluation consisted of two parts. The first one, conducted in the central laboratory, focused on the analytical performances of the AQT βhCG assay. The second one, conducted in the ED, aimed at determining the impact of POCT βhCG implementation on the timeframe in which ED patients require βhCG assessment. Results: The within-lab imprecisions at the mean values of 17 and 287 IU/L were 2.7% and 3.7%, respectively. Using Deming regression (n = 60), the following equation was obtained in the central lab: AQT90 βhCG = 1.1 Roche βhCG—12.9 (r = 0.997). The implementation of POCT βhCG in the ED significantly reduced patient LOS (145 (90–212) min vs. 205 (155–265) with and without AQT90, respectively, p < 0.001). At the 2 IU/L decision level, a 99.7% agreement with the Roche assay was reported (kappa statistics, 0.99). Conclusions: We confirm that the analytical qualities of the AQT 90 were in line with those obtained in the central lab. The implementation of the POCT βhCG is associated with a shorter LOS in the ED due to the faster availability of the results and the faster decision-making possibilities.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Optimization of Patient Management in the Gynecology Emergency Department Using Point-of-Care Beta hCG

et al. 2022

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Acute Stroke Biomarkers: Are We There Yet?

et al. 2021

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Background: Distinguishing between stroke subtypes and knowing the time of stroke onset are critical in clinical practice. Thrombolysis and thrombectomy are very effective treatments in selected patients with acute ischemic stroke. Neuroimaging helps decide who should be treated and how they should be treated but is expensive, not always available and can have contraindications. These limitations contribute to the under use of these reperfusion therapies.Aim: An alternative approach in acute stroke diagnosis is to identify blood biomarkers which reflect the body's response to the damage caused by the different types of stroke. Specific blood biomarkers capable of differentiating ischemic from hemorrhagic stroke and mimics, identifying large vessel occlusion and capable of predicting stroke onset time would expedite diagnosis and increase eligibility for reperfusion therapies.Summary of Review: To date, measurements of candidate biomarkers have usually occurred beyond the time window for thrombolysis. Nevertheless, some candidate markers of brain tissue damage, particularly the highly abundant glial structural proteins like GFAP and S100β and the matrix protein MMP-9 offer promising results. Grouping of biomarkers in panels can offer additional specificity and sensitivity for ischemic stroke diagnosis. Unbiased “omics” approaches have great potential for biomarker identification because of greater gene, protein, and metabolite coverage but seem unlikely to be the detection methodology of choice because of their inherent cost.Conclusion: To date, despite the evolution of the techniques used in their evaluation, no individual candidate or multimarker panel has proven to have adequate performance for use in an acute clinical setting where decisions about an individual patient are being made. Timing of biomarker measurement, particularly early when decision making is most important, requires urgent and systematic study.

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Performance of a quick pregnancy test on whole blood in early pregnancy units: a prospective cohort study

Abstract: The NG-Test hCG WB showed a high sensitivity, specificity, PPV, and NPV. Its use as triage in the case of a negative pelvic ultrasound exam is a potential strategy to improve patient flow, with an average time saving of 85 min.

Cited by 2 publications

References 15 publications

Optimization of Patient Management in the Gynecology Emergency Department Using Point-of-Care Beta hCG

Optimization of Patient Management in the Gynecology Emergency Department Using Point-of-Care Beta hCG

Acute Stroke Biomarkers: Are We There Yet?

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