Performance of an Imaging System vs. Manual Screening in the Detection of Squamous Intraepithelial Lesions of the Uterine Cervix

Dziura, Bruce; Quinn, Sarah; Richard, Kathleen

doi:10.1159/000325959

Cited by 87 publications

(93 citation statements)

References 4 publications

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“…9 Dziura et al and Miller et al also described a significant increase in the detection of histologically proven HSIL in both the atypical squamous cells cannot exclude high-grade squamous intraepithelial lesion (ASC-H) and HSIL cytology categories in their practice. 10,11 An increased accuracy in the detection of HSIL was also reported by Chivukula et al with the use of TIS. 12 Davey et al reported that the TIS detected 1.29 more cases of histologic HSIL per 1000 women screened than conventional cytology.…”

Section: Discussionmentioning

confidence: 59%

Effectiveness of the Thin Prep® Imaging System in the detection of adenocarcinoma of the gynecologic system

Friedlander

Rudomina

Lin

2007

Cancer

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Section: Discussionmentioning

confidence: 59%

Effectiveness of the Thin Prep® Imaging System in the detection of adenocarcinoma of the gynecologic system

Friedlander

Rudomina

Lin

2007

Cancer

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“…21 Recently, the ThinPrep Imaging System has been shown to considerably improve the sensitivity of the Pap test. [6][7][8]22,23 Even with advanced technologies and rescreening negative Pap tests in HR-HPV-positive cases, the results of the current study demonstrate that cytology alone missed significant cervical lesions (CIN2þ) in this low-risk population. In addition, histologic follow-up in women with positive HR-HPV indicated that high-grade cervical lesions (CIN2þ) were underdiagnosed on cytology in 13% of women with ASCUS and in 21% of women with LSIL ( Table 1).…”

Section: Discussionmentioning

confidence: 88%

Image‐guided ThinPrep Papanicolaou tests and cotesting with high‐risk human papillomavirus in women aged 30 years and older in a low‐risk private practice population

Smith

Schwartz

et al. 2009

Cancer Cytopathology

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BACKGROUND:Screening for cervical cancer precursors has evolved considerably with the introduction of new technologies to improve the early detection of disease. The objective of this study was to analyze the accuracy and effectiveness of combined screening with cytology and high‐risk human papillomavirus (HR‐HPV) testing in a low‐risk population of women aged ≥30 years.METHODS:Consecutive unselected samples from a group of 1871 women aged ≥30 years were screened with image‐guided ThinPrep tests and HR‐HPV tests during a 6‐month period. Histologic follow‐up was reviewed among women with positive HR‐HPV tests.RESULTS:A total of 85 (4.5%) women had positive HR‐HPV tests. In 48 HR‐HPV–positive women with follow‐up biopsies, 41 (85%) were found to have histologic abnormalities. Thirty‐three (1.9%) women with cytologically normal Papanicolaou (Pap) tests harbored HR‐HPV, and a cervical intraepithelial neoplasia (CIN) 2+ lesion was detected in 1 (16%) of 6 women with histologic follow‐up. Conversely, 2 (28%) of 7 women with high‐grade intraepithelial lesion on cytology tested negative for HR‐HPV during the same period. A case of serous carcinoma with atypical glandular cells on cytology was also negative for HR‐HPV, as expected.CONCLUSIONS:In this low‐risk population of women aged ≥30 years, histology‐confirmed CIN2+ lesions were identified in women with negative cytology and positive HR‐HPV tests, as well as in those with positive cytology and negative HR‐HPV tests. Because both cytology and HPV testing alone missed significant lesions, cotesting with Pap and HR‐HPV in women aged ≥30 years appears to be a reasonable option in a low‐risk population. (Cancer Cytopathol) 2009. © 2009 American Cancer Society.

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“…6 As stated in Chapter 1 and shown in Table 1, previous studies comparing automated with manual reading have tended to indicate higher rates of cytological abnormality and some have found increased rates of CIN2+. Some of these studies 23,27 have been performed simply comparing cytological abnormality rates in consecutive periods of time, and others have used a split sample design, 16,24,26 whereby the same sample has been split between a conventional or LBC slide which is manually read and a slide which is subjected to automated reading. Many studies do not use histology as an outcome.…”

Section: Discordant Resultsmentioning

confidence: 99%

MAVARIC – a comparison of automation-assisted and manual cervical screening: a randomised controlled trial

Kitchener¹,

Blanks²,

Cubie³

et al. 2011

Clinical Governance: An International Journal

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Performance of an Imaging System vs. Manual Screening in the Detection of Squamous Intraepithelial Lesions of the Uterine Cervix

Cited by 87 publications

References 4 publications

Effectiveness of the Thin Prep® Imaging System in the detection of adenocarcinoma of the gynecologic system

Effectiveness of the Thin Prep® Imaging System in the detection of adenocarcinoma of the gynecologic system

Image‐guided ThinPrep Papanicolaou tests and cotesting with high‐risk human papillomavirus in women aged 30 years and older in a low‐risk private practice population

MAVARIC – a comparison of automation-assisted and manual cervical screening: a randomised controlled trial

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