A significant fundamental change in healthcare can be seen by the integration of artificial intelligence (AI) and machine learning (ML) with medical imaging (MI). This integration holds the potential to improve patient care standards, change clinical procedures, and improve diagnostic accuracy. This chapter presents the possible impact, addressed challenges, opportunities, and impacts on medical diagnosis of recent advancements and growing advances in the application of AI and ML in the field of MI. The rapid development of AI and ML technologies have pushed MI into a new phase of data-driven healthcare and personalized medicine. Furthermore, the applications of AI and ML in MI are a variety of including automated picture analysis and disease identification to prediction, revolutionizing pathology and radiology, and healthcare management. It also suggests a future in which these innovations will work together to improve patient care, improve diagnostic accuracy, and advance healthcare delivery.