Performance of lung cancer screening with low‐dose CT in Gejiu, Yunnan: A population‐based, screening cohort study

Abstract

Background: The performance of lung cancer screening with low-dose computed tomography (CT) (LDCT) in China is uncertain. This study aimed to evaluate the performance of LDCT lung cancer screening in the Chinese setting. Methods: In 2014, a screening cohort of lung cancer with LDCT was established in Gejiu, Yunnan Province, a screening center of the Lung Cancer Screening Program in Rural China (LungSPRC). Participants received a baseline screening and four rounds of annual screening with LDCT in two local hospitals until June 2019. We analyzed the rates of participation, detection, early detection, and the clinical characteristics of lung cancer. Results: A total of 2006 participants had complete baseline screening results with a compliance rate of 98.4%. Of these, 1411 were high-risk and 558 were nonhigh-risk participants. During this period, 40 lung cancer cases were confirmed, of these, 35 were screen-detected, four were post-screening and one was an interval case. The positive rate of baseline and annual screening was 9.7% and 9.0%, while the lung cancer detection rate was 0.4% and 0.6%, respectively. The proportion of early lung cancer increased from 37.5% in T0 to 75.0% in T4. Adenocarcinoma was the most common histological subtype. Lung cancer incidence according to the criteria of LungSPRC and National Lung Cancer Screening Trial (NLST) was 513.31 and 877.41 per 100 000 person-years, respectively. Conclusions: The program of lung cancer screening with LDCT showed a successful performance in Gejiu, Yunnan. However, further studies are warranted to refine a high-risk population who will benefit most from LDCT screening and reduce the high false positive results. Key points: This study reports the results of lung cancer screening with LDCT in Gejiu, Yunnan, a high-risk area of lung cancer, and it demonstrates that lung cancer screening with LDCT is effective in detecting early-stage lung cancer. Our program provides an opportunity to explore the performance of LDCT lung cancer screening in the Chinese context.

Community-based lung cancer screening by low-dose computed tomography in China: First round results and a meta-analysis

“…The literature search yielded 16 LDCT screening studies for lung cancer [12,[26][27][28][29][30][31][32][33][34][35][36][37][38][39][40], and all were included in the meta-analysis. Of those, 14 were conducted in mainland China, 9 were conducted in a general population, and 7 were conducted in high-risk populations (definitions of high-risk varied; Table S3).…”

Interventions of Advanced Lung Cancer Patient Receiving Chemotherapy by Computed Tomography Image Information Data Analysis-Based Soothing Care Plans

“…The early symptoms of patients are cough, chest pain, etc., and late stage patients will have symptoms of tumor metastasis and dyspnea, which seriously affects the normal life of patients [ 12 ]. When the patient's respiratory function is seriously obstructed, there will be a sense of impending death, which makes the patient feel pessimistic and painful and produces a sense of fear [ 13 ]. Soothing and targeted care for patients with lung cancer can improve their pessimism, make them feel warm, and stabilize their psychological state [ 14 ].…”

Association of cancer screening and residing in a coal-polluted East Asian region with overall survival of lung cancer patients: a retrospective cohort study

“…The sample size of lung cancer patients diagnosed by screening was relatively small. The patients who were diagnosed by screening in our study cohort were a mixture of patients diagnosed in real life clinical practice and participants in various lung cancer screening programs which might have participation rates of the target population to be screened that varied from 31.91% to 84.5% 51,52 . Given the retrospective nature of our study, errors in data collection might have occurred although care was taken to independently confirm the data wherever possible (e.g., verification of region of residence using geocode and map plotting).…”