Performance of polylactic acid/polycaprolactone/microcrystalline cellulose biocomposites with different filler contents and maleic anhydride compatibilization

Ye, Gaoyuan; Li, Zelong; Chen, Boyuan; Bai, Xiangzhi; Chen, Xu; Hu, Yingcheng

doi:10.1002/pc.26807

Cited by 19 publications

(20 citation statements)

References 38 publications

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“…41 This signal indicated that MA monomers were grafted onto the PLA backbone when MA was transformed to a saturated anhydride, with the occurrence of succinic anhydride end-grafting, which is a desirable structure of grafted polymers. 42 The absence of a band at 1590 cm −1 , related to cyclic C = C stretching of MA, 43 indicated that MA was grafted onto PLA. The characteristic peak of anhydride at 1750 cm −1 could not be easily identified, due to overlap with the intense peak for C = O in PLA.…”

Section: Resultsmentioning

confidence: 99%

Grafting of maleic anhydride on poly(lactic acid)/hydroxyapatite composites augments their ability to support osteogenic differentiation of human mesenchymal stem cells

et al. 2022

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Implantation of bone substitutes is the treatment of choice for bone defects exceeding a critical size, when self-healing becomes impossible. The use of 3D printing techniques allows the construction of scaffolds with customized properties. However, there is a lack of suitable materials for bone replacement. In this study, maleic anhydride-grafted poly (lactic acid) (MAPLA) was investigated as a potential compatibilizer agent for 3D-printed polylactic acid (PLA)/hydroxyapatite (HA) composites, in order to enhance the physicochemical and biological properties of the scaffolds. The grafting process was performed by reactive processing in a torque rheometer, with the evaluation of the use of different concentrations of maleic anhydride (MA). The success of the grafting reaction was confirmed by titration of acid groups and spectroscopic analyses, indicating the presence of succinic anhydride groups on the PLA chain. Morphological analysis of the PLA/HA 3D scaffolds, using SEM, revealed that the use of the compatibilizer resulted in a structure free from voids and holes. The compatibilization also increased the degradation process. On the other hand, TGA and DSC analyses revealed that the use of a compatibilizer had little effect on the thermal properties of the composite. Most importantly, the samples with compatibilizer were demonstrated to have a minimal cytotoxic effect on human mesenchymal stem cells (MSCs), promoting the osteogenic differentiation of these cells in a medium without the addition of classical osteogenic factors. Therefore, the grafting of PLA/HA composites improved their physicochemical and biological properties, especially the induction of MSC osteogenic differentiation, demonstrating the potential of these scaffolds for bone tissue replacement.

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Section: Resultsmentioning

confidence: 99%

Grafting of maleic anhydride on poly(lactic acid)/hydroxyapatite composites augments their ability to support osteogenic differentiation of human mesenchymal stem cells

et al. 2022

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“…The FTIR of PLA and PLA-g-GMA spectra are presented in Figure 4A. The asymmetric vibration peak of epoxy group of GMA appeared in PLA-g-GMA 13 C NMR and (B) 1 H NMR spectra of PLA and PLA-g-GMA.…”

Section: Compatibilizer Analysismentioning

confidence: 99%

“…Polylactic acid (PLA) served as the most promising biodegradable polymer has high strength, great biocompatibility, and excellent processing property. [ 1 ] In addition, there is a variety of raw materials for synthesizing PLA, including wheat, corn, and potato. However, due to the specialty of the molecular structure, PLA has significant drawbacks that restrict the range of applications, including high brittleness and low crystallinity.…”

Section: Introductionmentioning

confidence: 99%

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Mechanical, thermal properties and shape memory behaviors of PLA/PCL/PLA‐g‐GMA blends

Chen

et al. 2023

Polymer Engineering & Sci

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To improve the toughness of polylactic acid (PLA), in this research, a tough polymer polycaprolactone (PCL) was combined with PLA to prepare blends, and a compatibilizer of glycidyl methacrylate grafted PLA (PLA‐g‐GMA) was produced to enhance the compatibility of PLA/PCL blend. Compared with PLA/PCL blend, the compatibilized blend exhibited a lower melting temperature and greater thermal stability. The tensile test indicates that the addition of compatibilizer greatly improved the toughness of the PLA/PCL blend. Particularly, the elongation at break of PLA/PCL blend with 6 wt% PLA‐g‐GMA increased to 370% and reached about 66 times of neat PLA. In addition, compatibilized blends have good shape memory performance. The research provides a simple and feasible method to overcome the brittleness of PLA, supplying a new strategy to modify PLA.

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“…Lastly, Ye et al called attention to the PCL/ PLA/ microcrystalline cellulose composites fabricated via extrusion technology. The innovative development exhibited high biocompatibility and adhesion of human breast cancer cells, indicating a bright future in bioengineering research [ 208 ].…”

Section: Introductionmentioning

confidence: 99%

Recent advances in modified poly (lactic acid) as tissue engineering materials

et al. 2023

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As an emerging science, tissue engineering and regenerative medicine focus on developing materials to replace, restore or improve organs or tissues and enhancing the cellular capacity to proliferate, migrate and differentiate into different cell types and specific tissues. Renewable resources have been used to develop new materials, resulting in attempts to produce various environmentally friendly biomaterials. Poly (lactic acid) (PLA) is a biopolymer known to be biodegradable and it is produced from the fermentation of carbohydrates. PLA can be combined with other polymers to produce new biomaterials with suitable physicochemical properties for tissue engineering applications. Here, the advances in modified PLA as tissue engineering materials are discussed in light of its drawbacks, such as biological inertness, low cell adhesion, and low degradation rate, and the efforts conducted to address these challenges toward the design of new enhanced alternative biomaterials.

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Performance of polylactic acid/polycaprolactone/microcrystalline cellulose biocomposites with different filler contents and maleic anhydride compatibilization

Cited by 19 publications

References 38 publications

Grafting of maleic anhydride on poly(lactic acid)/hydroxyapatite composites augments their ability to support osteogenic differentiation of human mesenchymal stem cells

Grafting of maleic anhydride on poly(lactic acid)/hydroxyapatite composites augments their ability to support osteogenic differentiation of human mesenchymal stem cells

Mechanical, thermal properties and shape memory behaviors of PLA/PCL/PLA‐g‐GMA blends

Recent advances in modified poly (lactic acid) as tissue engineering materials

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