This review focuses on recent developments in fabrication of multiple emulsions in microscale systems, such as membrane, microchannel array and microfluidic emulsification devices.Membrane and microchannel emulsification offer great potential in manufacturing multiple emulsions with uniform drop sizes and high encapsulation efficiency of encapsulated actives.Microfluidic devices enable unprecedented level of control over the number, size and type of internal droplets at each hierarchical level but suffer from low production scales. Microfluidic methods can be exploited to generate high-order multiple emulsions (triple, quadruple and quintuple), non-spherical (discoidal and rod-like) drops and drops with asymmetric properties such as Janus and ternary drops, composed of two or three distinct regions on the surface.Multiple emulsion droplets generated in microfabricated devices can be used as templates for vesicles (polymersomes, liposomes, colloidosomes) with multiple inner compartments for simultaneous encapsulation and release of incompatible actives or reactants.-2-