Performance of the BACTEC MGIT 960 compared with solid media for detection of Mycobacterium in Bangkok, Thailand

Srisuwanvilai, La-Ong; Monkongdee, Patama; Podewils, Laura Jean; Ngamlert, Keerataya; Pobkeeree, Vallerut; Puripokai, Panitchaya; Kanjanamongkolsiri, Photjanart; Subhachaturas, Wonchat; Akarasewi, Pasakorn; Wells, Charles D.; Tappero, Jordan W.; Varma, Jay K.

doi:10.1016/j.diagmicrobio.2008.02.015

Cited by 38 publications

(37 citation statements)

References 15 publications

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“…For the 4 patients who had NTM isolated from normally sterile sites, NTM most likely was a causative factor, but the role is less clear in those in whom it was isolated from sputum or stool. Expanding mycobacterial culture capacity will help better assess the impact of NTM disease in Asia because NTM may be an underappreciated cause of death among patients clinically diagnosed with TB (40). Fungal infections may be preventable with prophylactic antifungal treatment; a previous analysis of risk factors for death in Thailand found that fl uconazole was associated with improved duration of survival (16).…”

Section: Discussionmentioning

confidence: 99%

Causes of Death in HIV-infected Persons Who Have Tuberculosis, Thailand

Cain¹,

Anekthananon²,

Burapat³

et al. 2009

Emerg. Infect. Dis.

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Up to 50% of persons with HIV and a diagnosis of tuberculosis (TB) in Thailand die during TB treatment. In a prospective observational study, a team of physicians ascribed the cause of death after reviewing verbal autopsies (interviews of family members about events preceding death), laboratory data, and medical records. Of 849 HIVinfected TB patients enrolled, 142 (17%) died. The cause of death was TB for 38 (27%), including 6 with multidrugresistant TB and 20 with disseminated TB; an HIV-associated condition other than TB for 50 (35%); and a condition unrelated to TB or HIV for 22 (15%). Twenty-three patients (16%) were judged not to have had TB at all. Death from all causes except those unrelated to TB or HIV was less common in persons receiving antiretroviral therapy (ART). In addition to increasing the use of ART, death rates may be reduced through expanded use of modern TB diagnostic techniques.

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Section: Discussionmentioning

confidence: 99%

Causes of Death in HIV-infected Persons Who Have Tuberculosis, Thailand

Cain¹,

Anekthananon²,

Burapat³

et al. 2009

Emerg. Infect. Dis.

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“…For all patients with a diagnosis of TB in the national infectious diseases hospital or any public or private facility in the four provinces, staff recorded standardized epidemiologic data, collected sputum specimens for microbiologic testing, and offered HIV counselling and testing. When available, sputum specimens from the beginning of TB treatment, were cultured in a government laboratory located in the province in which the specimen was collected; Ogawa or Lowenstein-Jensen agar and, in some situations, mycobacterial growth indicator tube (MGIT) were used, according to standard procedures (Varma et al 2007;Srisuwanvilai et al 2008). Isolates were sent to the Bangkok city or MOPH national reference laboratory for identification and drug-susceptibility testing.…”

Section: Data Collectionmentioning

confidence: 99%

Factors associated with death among HIV‐uninfected TB patients in Thailand, 2004–2006

Amnuaiphon

Anuwatnonthakate

Nuyongphak

et al. 2009

Tropical Med Int Health

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Summaryobjectives In countries with both TB and human immunodeficiency virus (HIV) epidemics, HIV is known to be the most powerful risk factor for death during tuberculosis (TB) treatment. Few recent studies have evaluated risk factors for death among HIV-uninfected TB patients in these countries. We analysed data from a multi-province demonstration project in Thailand to answer this question.method We prospectively collected data from HIV-uninfected TB patients treated for TB in four provinces and the national infectious diseases hospital in Thailand from [2004][2005][2006]. Standard WHO definitions were used to classify treatment outcomes. We used log-binomial multivariate regression to calculate adjusted relative risk (aRR) and 95% confidence intervals (CI) for factors associated with death.

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“…Scores of studies including at national TB control program level across the globe have compared the added advantages of automated liquid culture over solid culture, to cite a few a department health study conducted at Bangkok, Thailand (n = 2566) showed 53% positive on liquid culture vs 39% in solid culture with time to detection shortened to 11 days vs 27 days, respectively, with significant value addition [8]; another Indian study showed 41% culture positive in MGIT culture vs 24% in solid culture with time to detection of 9 days vs 38 days, respectively (n = 14,957). In the Indian study, MGIT showed its significant value addition in case of sputum smear negative samples with 18% positivity by MGIT vs 1% over solid culture with time to detection of 16 days vs 48 days, respectively [9].…”

Section: Current Toolsmentioning

confidence: 99%

True facets of TB diagnosis in 2012: Hypes and realities

Parida¹

2012

European Journal of Microbiology and Immunology

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Tuberculosis takes a heavy toll of ~5000 lives every day from the disease; responsible for the 86% of DALY burden. Despite having drugs to treat TB efficiently, we have failed to control the disease. Mycobacterium tuberculosis has exploited it to their advantage evolving with multiple mutations making it resistant to first-line and second-line drugs. Most of the high-burden countries are lowmedium income countries, their national TB program (NTP) still use sputum smear microscopy as the tool of diagnosis. Many new molecular tools are emerging, but confuse the larger TB clinical scientific community at the NTPs. Coherent information need to be disseminated, encouraging TB scientific community to generate evidences within NTPs assessing new tools through critical analyses in terms of value addition and cost benefit before considering rolling out in the program. It is also imperative that the scientific community need to have an open mind to use different tools in the right permutation and combination than being exclusive of one another. This article portrays an overview of the diagnostics landscape in 2012 with pros and cons of different tools to be able to generate a step-wise algorithm for optimal exploitation of the tools within available resources in each of the settings.

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Performance of the BACTEC MGIT 960 compared with solid media for detection of Mycobacterium in Bangkok, Thailand

Cited by 38 publications

References 15 publications

Causes of Death in HIV-infected Persons Who Have Tuberculosis, Thailand

Causes of Death in HIV-infected Persons Who Have Tuberculosis, Thailand

Factors associated with death among HIV‐uninfected TB patients in Thailand, 2004–2006

True facets of TB diagnosis in 2012: Hypes and realities

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