Performance Study of a Radio-Frequency Field-Penetrable PET Insert for Simultaneous PET/MRI

Abstract

Hybrid positron emission tomography (PET)/magnetic resonance imaging (MRI) has risen to the cutting edge of medical imaging technology as it allows simultaneous acquisition of structural, functional and molecular information of the patient. A PET insert that can be installed into existing MR systems can in principle reduce the cost barriers for an existing MR site to achieve simultaneous PET/MRI compared to procuring an integrated PET+MRI system. The PET insert systems developed so far for PET/MRI require the RF transmitter coil to reside inside the PET ring as those PET inserts block the RF fields from the MRI system. Here we report for the first time on the performance of a full-ring brain-sized “RF-penetrable” PET insert we have recently completed. This insert allows the RF fields generated by the built-in body coil to penetrate the PET ring. The PET insert comprises a ring of 16 detector modules employing electro-optical coupled signal transmission and a multiplexing framework based on compressed sensing. Energy resolution, coincidence timing resolution (CTR), photopeak position, and coincidence count rate were acquired outside and inside a 3-Tesla MRI system under simultaneous acquisition to evaluate the impact of MRI on the PET performance. Coincidence count rate performance was evaluated by acquiring a cylinder source with high initial activity decaying over time. Tomographic imaging of two phantoms, a custom 6.5-cm diameter resolution phantom with hot rods of four different sizes (2.8 mm, 3.2 mm, 4.2 mm, and 5.2 mm diameter) and a 3D Hoffman brain phantom, were performed to evaluate the imaging capability of the PET insert. The energy resolution at 511 keV and CTR acquired by the PET insert were 16.2±0.1% and 5.3±0.1 ns FWHM, respectively, and remained stable during MRI operation except when the EPI sequence was applied. The PET system starts to show saturation in coincidence count rate at 2.76 million photon counts per second. Most of the 2.8-mm diameter hot rods and main features of the 3D Hoffman brain phantom were resolved by the PET insert, demonstrating its high spatial resolution and capability to image a complex tracer distribution mimicking that seen in the human brain.

Initial Characterization of the SAFIR Prototype PET-MR Scanner

“…Since the minimum in between the photopeak and the Compton edge is around 390 keV, we selected an energy window from 391 keV to 601 keV for the analysis. To the best of our knowledge, there is no preclinical PET scanner with a better CTR than the reported 194 ps (FWHM) at low activity [16]- [27]. The majority of the 511-keV gamma rays are scattered in the LYSO crystals [28], [29].…”

Development and Initial Results of a Brain PET Insert for Simultaneous 7-Tesla PET/MRI Using an FPGA-Only Signal Digitization Method

“…Chang et al [55] at Stanford University developed an RFpenetrable PET insert that allows the RF signal of the MRI body coil to penetrate the PET gantry. The PET insert uses an electrooptical coupling method and a battery power to separate the PET and MRI ground.…”

In vitroandin vivosigma 1 receptor imaging studies in different disease states

“…Remarkably, PET/MRI has a great advantage of combining the high sensitivity and molecular imaging properties of PET with the ability of MRI to penetrate tissues and provide superior soft tissue contrast, and detect anatomical details with high spatial resolution and low noise. 181,182 The complementary role of PET/MRI has opened new opportunities in non-invasive imaging to RSC Medicinal Chemistry Review visualize both biochemical and anatomical changes and provide more accurate measurements of radioligand uptake. 64,183 The clinical use of PET/MRI and the [ 18 F]FTC146 PET tracer was reported for imaging peripheral nerve injury and the origin of chronic pain in humans successfully, which was not accessible using only CT or MRI.…”