Perfused lung volume to thoracic gas volume ratio (perfused lung fraction) in patients with COPD and in controls

Masiero, Paulo Ricardo; Menna-Barreto, Sérgio Saldanha; Moreira, Maria Angela Fontoura; Mosmann, Marcos Pretto; Mayer, Caroline; Spiro, Bernardo Leão

doi:10.1097/mnm.0b013e32834207cb

Cited by 3 publications

(1 citation statement)

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“…They observed that the lung-volume fraction that receives blood from the pulmonary artery was reduced in these patients and that the degree of underperfusion correlated with the FEV 1 :FVC value ( r =0597; P <0.001). 39 …”

Section: Resultsmentioning

confidence: 99%

Brazilian studies on pulmonary function in COPD patients: what are the gaps?

Lopes

Melo

2016

COPD

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BackgroundCOPD is a major cause of death and morbidity worldwide, and is characterized by persistent airflow obstruction. The evaluation of obstruction is critically dependent on sensitive methods for lung-function testing. A wide body of knowledge has been accumulated in recent years showing that these methods have been significantly refined and seems promising for detection of early disease.ObjectivesThis review focuses on research on pulmonary function analysis in COPD performed in Brazil during this century.Materials and methodsThe literature was searched using a systematic search strategy limited to English language studies that were carried out in Brazil from the year 2000 onward, with study objectives that included a focus on lung function.ResultsAfter we applied our inclusion and exclusion criteria, 94 articles addressed our stated objectives. Among the new methods reviewed are the forced-oscillation technique and the nitrogen-washout test, which may provide information on small-airway abnormalities. Studies investigating the respiratory muscles and thoracoabdominal motion are also discussed, as well as studies on automatic clinical decision-support systems and complexity measurements. We also examined important gaps in the present knowledge and suggested future directions for the cited research fields.ConclusionThere is clear evidence that improvements in lung-function methods allowed us to obtain new pathophysiological information, contributing to improvement in our understanding of COPD. In addition, they may also assist in the diagnosis and prevention of COPD. Further investigations using prospective and longitudinal design may be of interest to elucidate the use of these new methods in the diagnosis and prevention of COPD.

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Section: Resultsmentioning

confidence: 99%

Brazilian studies on pulmonary function in COPD patients: what are the gaps?

Lopes

Melo

2016

COPD

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Pulmonary function–morphologic relationships assessed by SPECT–CT fusion images

Suga¹

2012

Ann Nucl Med

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Pulmonary single photon emission computed tomography-computed tomography (SPECT-CT) fusion images provide objective and comprehensive assessment of pulmonary function and morphology relationships at cross-sectional lungs. This article reviewed the noteworthy findings of lung pathophysiology in wide-spectral lung disorders, which have been revealed on SPECT-CT fusion images in 8 years of experience. The fusion images confirmed the fundamental pathophysiologic appearance of lung low CT attenuation caused by airway obstruction-induced hypoxic vasoconstriction and that caused by direct pulmonary arterial obstruction as in acute pulmonary thromboembolism (PTE). The fusion images showed better correlation of lung perfusion distribution with lung CT attenuation changes at lung mosaic CT attenuation (MCA) compared with regional ventilation in the wide-spectral lung disorders, indicating that lung heterogeneous perfusion distribution may be a dominant mechanism of MCA on CT. SPECT-CT angiography fusion images revealed occasional dissociation between lung perfusion defects and intravascular clots in acute PTE, indicating the importance of assessment of actual effect of intravascular colts on peripheral lung perfusion. Perfusion SPECT-CT fusion images revealed the characteristic and preferential location of pulmonary infarction in acute PTE. The fusion images showed occasional unexpected perfusion defects in normal lung areas on CT in chronic obstructive pulmonary diseases and interstitial lung diseases, indicating the ability of perfusion SPECT superior to CT for detection of mild lesions in these disorders. The fusion images showed frequent "steal phenomenon"-induced perfusion defects extending to the surrounding normal lung of arteriovenous fistulas and those at normal lungs on CT in hepatopulmonary syndrome. Comprehensive assessment of lung function-CT morphology on fusion images will lead to more profound understanding of lung pathophysiology in wide-spectral lung disorders.

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