2024
DOI: 10.1002/bit.28880
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Perfusion Process Intensification for Lentivirus Production Using a Novel Scale‐Down Model

Maximilian Klimpel,
Beatrice Pflüger‐Müller,
Marta Arrizabalaga Cascallana
et al.

Abstract: Process intensification has become an important strategy to lower production costs and increase manufacturing capacities for biopharmaceutical products. In particular for the production of viral vectors like lentiviruses (LVs), the transition from (fed‐)batch to perfusion processes is a key strategy to meet the increasing demands for cell and gene therapy applications. However, perfusion processes are associated with higher medium consumption. Therefore, it is necessary to develop appropriate small‐scale model… Show more

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