Perfusion Scintigraphy as a Prognostic Tool for Lung Volume Reduction Surgery Outcomes.

Chandra, Divay; Lipson, D.A.; Hansen‐Flaschen, John; DeCamp, Malcom McAvoy; Reilly, Jr Jj; Washko, G.R.

doi:10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a6172

D101. New Aspects of Interventional Pulmonology/Bronchoscopy 2009

DOI: 10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a6172

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Perfusion Scintigraphy as a Prognostic Tool for Lung Volume Reduction Surgery Outcomes.

Divay Chandra

D.A. Lipson

John Hansen‐Flaschen

et al.

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“…We hypothesized that perfusion scintigraphy would complement visual examination of the chest CT in selecting patients for LVRS. Some of the results of this study have been previously reported in the form of an abstract (12).…”

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confidence: 78%

Perfusion Scintigraphy and Patient Selection for Lung Volume Reduction Surgery

Chandra¹,

Lipson²,

Hoffman³

et al. 2010

Am J Respir Crit Care Med

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Rationale: It is unclear if lung perfusion can predict response to lung volume reduction surgery (LVRS). Objectives: To study the role of perfusion scintigraphy in patient selection for LVRS. Methods: We performed an intention-to-treat analysis of 1,045 of 1,218 patients enrolled in the National Emphysema Treatment Trial who were non-high risk for LVRS and had complete perfusion scintigraphy results at baseline. The median follow-up was 6.0 years. Patients were classified as having upper or non-upper lobepredominant emphysema on visual examination of the chest computed tomography and high or low exercise capacity on cardiopulmonary exercise testing at baseline. Low upper zone perfusion was defined as less than 20% of total lung perfusion distributed to the upper third of both lungs as measured on perfusion scintigraphy. Measurements and Main Results: Among 284 of 1,045 patients with upper lobe-predominant emphysema and low exercise capacity at baseline, the 202 with low upper zone perfusion had lower mortality with LVRS versus medical management (risk ratio [RR], 0.56; P 5 0.008) unlike the remaining 82 with high perfusion where mortality was unchanged (RR, 0.97; P 5 0.62). Similarly, among 404 of 1,045 patients with upper lobe-predominant emphysema and high exercise capacity, the 278 with low upper zone perfusion had lower mortality with LVRS (RR, 0.70; P 5 0.02) unlike the remaining 126 with high perfusion (RR, 1.05; P 5 1.00). Among the 357 patients with non-upper lobe-predominant emphysema (75 with low and 282 with high exercise capacity) there was no improvement in survival with LVRS and measurement of upper zone perfusion did not contribute new prognostic information. Conclusions: Compared with optimal medical management, LVRS reduces mortality in patients with upper lobe-predominant emphysema when there is low rather than high perfusion to the upper lung.

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mentioning

confidence: 78%

Perfusion Scintigraphy and Patient Selection for Lung Volume Reduction Surgery

Chandra¹,

Lipson²,

Hoffman³

et al. 2010

Am J Respir Crit Care Med

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Perfusion Scintigraphy as a Prognostic Tool for Lung Volume Reduction Surgery Outcomes.

Cited by 1 publication

References 0 publications

Perfusion Scintigraphy and Patient Selection for Lung Volume Reduction Surgery

Perfusion Scintigraphy and Patient Selection for Lung Volume Reduction Surgery

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