Periconceptional folate consumption is associated with neonatal DNA methylation modifications in neural crest regulatory and cancer development genes

Gonseth, Semira; Roy, Ritu; Houseman, E. Andrés; Smith, Adam J. de; Zhou, Mi; Lee, Seung Tae; Nusslé, Sébastien; Singer, Adolf; Wrensch, Margaret; Metayer, Catherine

doi:10.1080/15592294.2015.1117889

Cited by 41 publications

(36 citation statements)

References 68 publications

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“…A recent example illustrates the complex association between in utero exposure to tobacco smoke and childhood cancer. A study of neonatal blood spots showed that DNA methylation at birth was altered in association with early pregnancy maternal folate status . DNA methylation marks of smoking demonstrated a difference between cases and controls (J. Wiemels, unpublished data), consistent with the interaction between maternal smoking in cancer risk in the offspring .…”

Section: Research Gaps and Needsmentioning

confidence: 75%

Roadmap for investigating epigenome deregulation and environmental origins of cancer

Herceg

Ghantous

Wild

et al. 2017

Intl Journal of Cancer

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The interaction between the (epi)genetic makeup of an individual and his/her environmental exposure record (exposome) is accepted as a determinant factor for a significant proportion of human malignancies. Recent evidence has highlighted the key role of epigenetic mechanisms in mediating gene–environment interactions and translating exposures into tumorigenesis. There is also growing evidence that epigenetic changes may be risk factor-specific (“fingerprints”) that should prove instrumental in the discovery of new biomarkers in cancer. Here, we review the state of the science of epigenetics associated with environmental stimuli and cancer risk, highlighting key developments in the field. Critical knowledge gaps and research needs are discussed and advances in epigenomics that may help in understanding the functional relevance of epigenetic alterations. Key elements required for causality inferences linking epigenetic changes to exposure and cancer are discussed and how these alterations can be incorporated in carcinogen evaluation and in understanding mechanisms underlying epigenome deregulation by the environment.

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Section: Research Gaps and Needsmentioning

confidence: 75%

Roadmap for investigating epigenome deregulation and environmental origins of cancer

Herceg

Ghantous

Wild

et al. 2017

Intl Journal of Cancer

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“…It is plausible that periconceptional folic acid could be a protective factor for CBT. Low folate levels at this time may be associated with increased DNA methylation, thereby suppressing expression of genes, such as OTX2, which are implicated in neural crest development in the critical first week following fertilisation …”

mentioning

confidence: 99%

Factors related to pregnancy and birth and the risk of childhood brain tumours: The ESTELLE and ESCALE studies (SFCE, France)

Bailey

Rios

Lacour

et al. 2017

Intl Journal of Cancer

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Little is known of the causes of childhood brain tumors (CBT). The aims of this study were to investigate whether extremes of birth weight were associated with increased risk of CBT and whether maternal preconceptional folic acid supplementation or breastfeeding reduced the risk. In addition, other maternal characteristics and birth related factors were also investigated. We pooled data from two French national population-based case-control studies with similar designs conducted in 2003-2004 and 2010-2011. The mothers of 510 CBT cases (directly recruited from the national childhood cancer register) and 3,102 controls aged under 15 years, frequency matched by age and gender did a telephone interview, which focussed on demographic and perinatal characteristics, and maternal life style habits and reproductive history. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using unconditional logistic regression, adjusted for age, sex, study of origin and relevant confounders. No association was found between CBT and birth weight or fetal growth. The use of preconceptional folic acid supplementation was rare (5.3% in cases and 7.8% in controls) and the OR was 0.8 (95% CI 0.5, 1.4). There was no association with breastfeeding, even prolonged (six months or more; OR 1.0, 95% CI 0.8, 1.4). Neither was there any association between CBT and other investigated factors (maternal body mass index, gestational weight gain, congenital abnormality, maternal reproductive history or use of fertility treatments. Although large, this study was underpowered for subtype analyses. Pooling data with other population-based studies may provide further insight into findings by CBT subtypes.

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“…31 Likewise, methylation changes have also been observed in response to folic acid exposures. 32 Our understanding of the specific effects of environmental exposures on epigenetic features is just in its infancy, and it is unknown whether these perturbations could impact leukemogenesis.…”

Section: Natural History Of Leukemia As a Diseasementioning

confidence: 99%

Childhood Leukemia and Primary Prevention

Whitehead

Metayer

Wiemels

et al. 2016

Current Problems in Pediatric and Adolescent Health Care

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110

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Leukemia is the most common pediatric cancer, affecting 3,800 children per year in the United States. Its annual incidence has increased over the last decades, especially among Latinos. Although most children diagnosed with leukemia are now cured, many suffer long-term complications, and primary prevention efforts are urgently needed. The early onset of leukemia – usually before age five – and the presence at birth of “pre-leukemic” genetic signatures indicate that pre- and postnatal events are critical to the development of the disease. In contrast to most pediatric cancers, there is a growing body of literature – in the United States and internationally – that has implicated several environmental, infectious, and dietary risk factors in the etiology of childhood leukemia, mainly for acute lymphoblastic leukemia, the most common subtype. For example, exposures to pesticides, tobacco smoke, solvents, and traffic emissions have consistently demonstrated positive associations with the risk of developing childhood leukemia. In contrast, intake of vitamins and folate supplementation during the pre-conception period or pregnancy, breastfeeding, and exposure to routine childhood infections have been shown to reduce the risk of childhood leukemia. Some children may be especially vulnerable to these risk factors, as demonstrated by a disproportionate burden of childhood leukemia in the Latino population of California. The evidence supporting the associations between childhood leukemia and its risk factors – including pooled analyses from around the world and systematic reviews – is strong; however, the dissemination of this knowledge to clinicians has been limited. To protect children’s health, it is prudent to initiate programs designed to alter exposure to well-established leukemia risk factors rather than to suspend judgement until no uncertainty remains. Primary prevention programs for childhood leukemia would also result in the significant co-benefits of reductions in other adverse health outcomes that are common in children, such as detriments to neurocognitive development.

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Periconceptional folate consumption is associated with neonatal DNA methylation modifications in neural crest regulatory and cancer development genes

Cited by 41 publications

References 68 publications

Roadmap for investigating epigenome deregulation and environmental origins of cancer

Roadmap for investigating epigenome deregulation and environmental origins of cancer

Factors related to pregnancy and birth and the risk of childhood brain tumours: The ESTELLE and ESCALE studies (SFCE, France)

Childhood Leukemia and Primary Prevention

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