2023
DOI: 10.1101/2023.10.26.564269
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Pericyte ablation causes hypoactivity and reactive gliosis in adult mice

Jake M. Cashion,
Lachlan S. Brown,
Gary P. Morris
et al.

Abstract: Pericytes are contractile cells that enwrap capillaries allowing them to control blood flow, maintain the blood-brain barrier and regulate immune cell trafficking in the CNS. Pericytes are lost or become dysfunctional in neurodegenerative diseases such as Alzheimer’s disease, stroke, and multiple sclerosis, but their role in health and disease is poorly understood. Our aim was to evaluate blood-brain barrier integrity and glial reactivity, and to assess behavioural phenotypes that emerge following pericyte abl… Show more

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