Pericyte Plasticity in the Brain

Santos, Gabryella S P; Magno, Luiz Alexandre V.; Romano-Silva, Marco Aurélio; Mintz, Akiva; Birbrair, Alexander

doi:10.1007/s12264-018-0296-5

Cited by 37 publications

(34 citation statements)

References 145 publications

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“…The perivascular niches are themself complex and heterogeneous composed by multiple other cell types in addition to endothelial cells in the neurogenic niches, such as perivascular astrocytes, perivascular neurons [106,110,111], perivascular macrophages [112–114], perivascular adventitial cells [115], perivascular fibroblasts [116], microglia [117], vascular smooth muscle cells [118], and pericytes subsets [119]. Interestingly, pericytes from several peripheral tissues have been shown to behave as stem cells [78,120–139,189,190], generating other cell types, and also to regulate the behavior of other stem cells, as hematopoietic stem cells in their niches [87,88,140–144]. Although growing evidence also shows that central nervous system pericytes alter their characteristics following stimuli and develop sternness [145–149], whether pericytes are an essential component of neural stem cell niche, and what are their exact roles remains unexplored.…”

Section: Perivascular Neural Stem Cell Nichementioning

confidence: 99%

Neural stem cell niche heterogeneity

Andreotti

Silva

Costa

et al. 2019

Seminars in Cell & Developmental Biology

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In mammals, new neurons can be generated from neural stem cells in specific regions of the adult brain. Neural stem cells are characterized by their abilities to differentiate into all neural lineages and to self-renew. The specific microenvironments regulating neural stem cells, commonly referred to as neurogenic niches, comprise multiple cell populations whose precise contributions are under active current exploration. Understanding the cross-talk between neural stem cells and their niche components is essential for the development of therapies against neurological disorders in which neural stem cells function is altered. In this review, we describe and discuss recent studies that identified novel components in the neural stem cell niche. These discoveries bring new concepts to the field. Here, we evaluate these recent advances that change our understanding of the neural stem cell niche heterogeneity and its influence on neural stem cell function.

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Section: Perivascular Neural Stem Cell Nichementioning

confidence: 99%

Neural stem cell niche heterogeneity

Andreotti

Silva

Costa

et al. 2019

Seminars in Cell & Developmental Biology

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“…The skin is composed by a complex microenvironment which contains several constituents, in addition to dendritic cells and CD8+ T cells: other immune cells, various types of stromal cells, innervations, stem cells, Schwann cells, and extracellular matrix proteins . This complex mixture of cells cooperate to perform the necessary functions for the skin healing, and the interplay between these distinct components of the cutaneous microenvironment will define the success of skin repair .…”

Section: Perspectives/future Directionsmentioning

confidence: 99%

Staphylococcus epidermidis role in the skin microenvironment

Leonel

Sena

Silva

et al. 2019

J Cellular Molecular Medi

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Wound healing is a complex dynamic physiological process in response to cutaneous destructive stimuli that aims to restore the cutaneous’ barrier role. Deciphering the underlying mechanistic details that contribute to wound healing will create novel therapeutic strategies for skin repair. Recently, by using state‐of‐the‐art technologies, it was revealed that the cutaneous microbiota interact with skin immune cells. Strikingly, commensal Staphylococcus epidermidis‐induced CD8+ T cells induce re‐epithelization of the skin after injury, accelerating wound closure. From a drug development perspective, the microbiota may provide new therapeutic candidate molecules to accelerate skin healing. Here, we summarize and evaluate recent advances in the understanding of the microbiota in the skin microenvironment.

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“…In addition, Birbrair et al[52] reported that nestin + /NG2 + type-2 pericytes have NG2 + glia-like traits. However, NG2 + glia is identical to OPCs[53], and both pericytes and OPCs express common markers, including NG2 and PDGFRα[54]. Thus, the precise connection between iNSPCs and resident glia should be determined in further studies (Figure 1).…”

Section: Brain Pericytes Following Ischemia: Do They Function As Nspcs?mentioning

confidence: 99%

Neural regeneration by regionally induced stem cells within post-stroke brains: Novel therapy perspectives for stroke patients

Nakagomi¹,

Takagi²,

Beppu³

et al. 2019

WJSC

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Ischemic stroke is a critical disease which causes serious neurological functional loss such as paresis. Hope for novel therapies is based on the increasing evidence of the presence of stem cell populations in the central nervous system (CNS) and the development of stem-cell-based therapies for stroke patients. Although mesenchymal stem cells (MSCs) represented initially a promising cell source, only a few transplanted MSCs were present near the injured areas of the CNS. Thus, regional stem cells that are present and/or induced in the CNS may be ideal when considering a treatment following ischemic stroke. In this context, we have recently showed that injury/ischemia-induced neural stem/progenitor cells (iNSPCs) and injury/ischemia-induced multipotent stem cells (iSCs) are present within post-stroke human brains and post-stroke mouse brains. This indicates that iNSPCs/iSCs could be developed for clinical applications treating patients with stroke. The present study introduces the traits of mouse and human iNSPCs, with a focus on the future perspective for CNS regenerative therapies using novel iNSPCs/iSCs.

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Pericyte Plasticity in the Brain

Cited by 37 publications

References 145 publications

Neural stem cell niche heterogeneity

Neural stem cell niche heterogeneity

Staphylococcus epidermidis role in the skin microenvironment

Neural regeneration by regionally induced stem cells within post-stroke brains: Novel therapy perspectives for stroke patients

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