Pericytes in Ischemic Stroke

Dalkara, Turgay; Alarcón-Martínez, Luis; Yemişçi, Müge

doi:10.1007/978-3-030-16908-4_9

Cited by 26 publications

(14 citation statements)

References 152 publications

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“…Pericyte is an important component of the blood-brain barrier and plays an important role in maintaining the structural stability and normal function of the BBB [ 1 , 2 ]. Under the condition of ischemic and hypoxic, pericytes involve in cerebral blood flow regulation, BBB destruction, and angiogenesis and have a significant role in the development of stroke disease [ 3 ]. Pericytes are multifunctional cells that express different function in different stages of stroke disease development [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of Pericytes on Cerebral Microvasculature at Different Time Points of Stroke

Zhong

Xie³

et al. 2021

BioMed Research International

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Pericyte, as an important component of the blood-brain barrier, has received increasing attention in the study of cerebrovascular diseases. However, the mechanism of pericytes after the occurrence of cerebral ischemia is controversial. On the one hand, the expression of pericytes increases after cerebral ischemia, constricting the blood vessels to restrict blood supply and aggravating the damage caused by ischemia; on the other hand, pericytes participate in capillary angiogenesis in the ischemic area, which facilitates the repair of the ischemic injury area. The multifunctionality of pericytes is an important reason for this phenomenon, but the different time points of observation for the outcome indicators in each study are also an important factor that leads to the controversy of pericytes. Based on the review of a large database of original studies, the authors’ team summarized the effects of pericytes on cerebral microvasculature at different time points after stroke, searched the possible markers, and explored possible therapeutic.

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Section: Introductionmentioning

confidence: 99%

Effect of Pericytes on Cerebral Microvasculature at Different Time Points of Stroke

Zhong

Xie³

et al. 2021

BioMed Research International

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“…In animals after focal brain injury, which have been injected with MSC into the carotid artery, MSCs were capable of homing to the perivascular space 35 , thereby showing no migration to deeper brain areas. The latter compartment is crucially involved in the replacement of injured pericytes, which facilitates restoration of central nervous system function 36 after brain damage and is also tightly linked to MSC 37 , potentially explaining why radiotracer signal also remained in the head area after carotid artery administration in our study. Moreover, in patients afflicted with heart failure, intramyocardial injection of MSC of individuals undergoing a left ventricular assist device implant did not lead to an increased rate of weaning from device support relative to patients without MSC injection into the myocardium 38 .…”

Section: Discussionmentioning

confidence: 69%

[18F]FDG-labelled stem cell PET imaging in different route of administrations and multiple animal species

Nose

Nogami

Koshino

et al. 2021

Sci Rep

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Stem cell therapy holds great promise for tissue regeneration and cancer treatment, although its efficacy is still inconclusive and requires further understanding and optimization of the procedures. Non-invasive cell tracking can provide an important opportunity to monitor in vivo cell distribution in living subjects. Here, using a combination of positron emission tomography (PET) and in vitro 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) direct cell labelling, the feasibility of engrafted stem cell monitoring was tested in multiple animal species. Human mesenchymal stem cells (MSCs) were incubated with phosphate-buffered saline containing [18F]FDG for in vitro cell radiolabelling. The pre-labelled MSCs were administrated via peripheral vein in a mouse (n = 1), rats (n = 4), rabbits (n = 4) and non-human primates (n = 3), via carotid artery in rats (n = 4) and non-human primates (n = 3), and via intra-myocardial injection in rats (n = 5). PET imaging was started 10 min after cell administration using a dedicated small animal PET system for a mouse and rats. A clinical PET system was used for the imaging of rabbits and non-human primates. After MSC administration via peripheral vein, PET imaging revealed intense radiotracer signal from the lung in all tested animal species including mouse, rat, rabbit, and non-human primate, suggesting administrated MSCs were trapped in the lung tissue. Furthermore, the distribution of the PET signal significantly differed based on the route of cell administration. Administration via carotid artery showed the highest activity in the head, and intra-myocardial injection increased signal from the heart. In vitro [18F]FDG MSC pre-labelling for PET imaging is feasible and allows non-invasive visualization of initial cell distribution after different routes of cell administration in multiple animal models. Those results highlight the potential use of that imaging approach for the understanding and optimization of stem cell therapy in translational research.

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“…In the 20 years following, from 2001 to early 2020, pericyte research has exploded with almost 2000 publications including brain and pericyte, while almost 50% of those publications included brain, pericyte and disease. The increase in interest regarding pericytes in the brain during disease highlights our growing understanding of how pericyte and vascular dysfunction can underly and exacerbate many disease processes, including common neurological disorders such as stroke 16 and Alzheimer’s Disease. 17…”

Section: The Popularity Of Brain Pericyte Research Is Increasingmentioning

confidence: 99%

The rise of pericytes in neurovascular research

Beard

Brown

Sutherland

2020

J Cereb Blood Flow Metab

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The popularity of pericyte research is increasing, and this was not more evident than at the recent 2019 Brain meeting in Yokohama which featured a large number of presentations focused on brain pericyte research, including the Presidential Symposium. In this article, we will provide a history of brain pericyte research, present the results of our analysis showing a substantial increase in brain pericyte research presented at Brain meetings since 2005, suggest reasons for their increased popularity, and comment on what the future holds for brain pericyte research.

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Pericytes in Ischemic Stroke

Cited by 26 publications

References 152 publications

Effect of Pericytes on Cerebral Microvasculature at Different Time Points of Stroke

Effect of Pericytes on Cerebral Microvasculature at Different Time Points of Stroke

[18F]FDG-labelled stem cell PET imaging in different route of administrations and multiple animal species

The rise of pericytes in neurovascular research

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