Pericytes in Vascular Development and Function

Daneman, Richard; Keller, Annika

doi:10.1007/978-1-4939-2907-8_3

Cited by 2 publications

(2 citation statements)

References 150 publications

(200 reference statements)

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“…Direct evidence regarding the influence of pericytes on capillary perfusion in vivo is still very limited. Pericytes are difficult to study in vivo due to heterogeneity along with a lack of selective molecular markers 240, 244 or cell-specific promoters.…”

Section: Part II Neurovascular Injury and Repair After Ischemic Strokementioning

confidence: 99%

Cerebral Vascular Disease and Neurovascular Injury in Ischemic Stroke

Silva

Chen

et al. 2017

Circulation Research

333

237

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The consequences of cerebrovascular disease are among the leading health issues worldwide. Large and small cerebral vessel disease can trigger stroke and contribute to the vascular component of other forms of neurological dysfunction and degeneration. Both forms of vascular disease are driven by diverse risk factors, with hypertension as the leading contributor. Despite the importance of neurovascular disease and subsequent injury following ischemic events, fundamental knowledge in these areas lag behind our current understanding of neuroprotection and vascular biology in general. The goal of this review is to address select key structural and functional changes in the vasculature that promote hypoperfusion and ischemia, while also affecting the extent of injury and effectiveness of therapy. In addition, as damage to the blood-brain barrier (BBB) is one of the major consequences of ischemia, we discuss cellular and molecular mechanisms underlying ischemia-induced changes in BBB integrity and function, including alterations in endothelial cells and the contribution of pericytes, immune cells, and matrix metalloproteinases. Identification of cell types, pathways, and molecules that control vascular changes before and after ischemia may result in novel approaches to slow the progression of cerebrovascular disease and lessen both the frequency and impact of ischemic events.

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Section: Part II Neurovascular Injury and Repair After Ischemic Strokementioning

confidence: 99%

Cerebral Vascular Disease and Neurovascular Injury in Ischemic Stroke

Silva

Chen

et al. 2017

Circulation Research

333

237

View full text Add to dashboard Cite

show abstract

“…While progress has been made regarding the influence of this cell type on blood-brain barrier integrity, other areas, such as the impact of pericytes on capillary perfusion are unsettled. Defining the impact of pericytes in vivo has been difficult for several reasons including pericyte heterogeneity and the lack of selective molecular markers (Armulik et al, 2011; Daneman, 2015) or cell-specific promoters. Experiments using truly pericyte-specific manipulations that then define the impact of these cells on microvascular biology in vivo have been lacking.…”

Section: Some Remaining Questionsmentioning

confidence: 99%

Microvascular Dysfunction and Cognitive Impairment

2016

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The impact of vascular risk factors on cognitive function has garnered much interest in recent years. The appropriate distribution of oxygen, glucose and other nutrients by the cerebral vasculature is critical for proper cognitive performance. The cerebral microvasculature is a key site of vascular resistance and a preferential target for small vessel disease. While deleterious effects of vascular risk factors on microvascular function are known, the contribution of this dysfunction to cognitive deficits is less clear. In this review, we summarize current evidence for microvascular dysfunction in brain. We highlight effects of select vascular risk factors (hypertension, diabetes and hyperhomocysteinemia) on the pial and parenchymal circulation. Lastly, we discuss potential links between microvascular disease and cognitive function, highlighting current gaps in our understanding.

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Pericytes in Vascular Development and Function

Cited by 2 publications

References 150 publications

Cerebral Vascular Disease and Neurovascular Injury in Ischemic Stroke

Cerebral Vascular Disease and Neurovascular Injury in Ischemic Stroke

Microvascular Dysfunction and Cognitive Impairment

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