Periestrous and Midluteal Time Courses of Circulating LH, FSH, Prolactin, Estradiol-17β and Progesterone in the Domestic Pig

Wiel, D.F.M. van de; Erkens, J. H. F.; Koops, W.; Vos, E. C.; Landeghem, A.A.J. van

doi:10.1095/biolreprod24.2.223

Cited by 167 publications

(69 citation statements)

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“…Thus, it seems that the main factor responsible for extremely high level of β-END-LI in small follicles taken in early luteal phase is just FSH. This finding is in good agreement with reports indicating that the highest plasma level of FSH takes place on day 3 of the pig oestrous cycle [42,50]. Moreover, granulosa cells from small follicles have approximately 5 times as many FSH receptors as granulosa cells from large ones [29] and FSH changes in follicular fluid β-END-LI levels are caused mainly by fluctuations in β-END-LI secretion by granulosa cells under influence of FSH and autocrine/ paracrine factors.…”

Section: Discussionsupporting

confidence: 92%

The physiological role of ?-endorphin in porcine ovarian follicles

et al. 2000

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-β-Endorphin-like immunoreactivity (β-END-LI) was measured by radioimmunoassay in porcine ovarian follicular fluid (FF) from small, medium and large follicles throughout the oestrous cycle. The concentration of β-END-LI in FF from small follicles collected on days 1-5 of the cycle was at least tenfold higher than in the fluid from any other follicles independently from their size and the period of the cycle. The level of β-END-LI in small follicles on days 6-10 was drastically decreased. Subsequently, on days 11-16 its concentration was enhanced and reduced again in preovulatory period of the cycle. Concentrations of β-END-LI in FF from medium follicles were relatively equal throughout the cycle (days 6-21). No significant differences in β-END-LI levels were found between small, medium and large follicles from days 17-21. However, β-END-LI concentrations in medium follicles on days 11-13 and 14-16 were statistically lower than those in small follicles. Moreover, the effects of FSH, prolactin (PRL), progesterone (P 4 ), testosterone (T) and 17 β-oestradiol (E 2 ) on β-END-LI release by granulosa cells (GCs) from large follicles and, on the other hand, the effects of the opioid agonist FK 33-824 alone or in combination with FSH, PRL or naloxone (NAL) on follicular steroidogenesis were studied. FSH drastically increased β-END-LI output in a dose-dependent fashion. This stimulatory effect of the gonadotrophin was inhibited by the highest dose of P 4 (10 -5 M). The effect of PRL and the steroids added to the cultures on β-END-LI release was negligible. FSH-or PRL-induced P 4 secretion by GCs was essentially abolished by both FK 33-824 and NAL. However, androstenedione (A 4 ) and testosterone output by the cells was greatly potentiated by FK 33-824. In the presence of NAL, FSH or PRL, A 4 release stimulated by FK 33-824 was suppressed to the basal level. Secretion of E 2 was completely free from the influence of FK 33-824 or NAL; only oestrone (E 1 ) output was modulated by them in cultures where FSH or PRL was present. In conclusion, FSH appears to be the key regulator of β-END-LI secretion by porcine granulosa cells. Moreover, steroidogenesis in pig granulosa cells is modulated by opioid peptides acting both alone and by way of interaction with FSH or PRL.opioid peptides / β-endorphin / porcine granulosa cells / steroid secretion Reprod. Nutr. Dev. 40 (2000) 63-75 63

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Section: Discussionsupporting

confidence: 92%

The physiological role of ?-endorphin in porcine ovarian follicles

et al. 2000

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“…1) corresponded to the basic physiologic pattern mentioned above, manifesting in an abrupt increase in serum E concentration immediately before the onset of oestrus. The results obtained were consistent with those published elsewhere (Guthrie et al, 1972;Van de Wiel et al, 1981). Upon atrazine treatment, the gilts failed to show the signs of the expected onset of oestrus, while the histopathological findings resembled the phase of uterine rest (dioestrus) (Fig.…”

Section: Discussionsupporting

confidence: 91%

Reproductive Disturbance Caused by an S-Triazine Herbicide in Pigs

Gojmerac

Uremović

et al. 1999

Acta Veterinaria Hungarica

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The aim of the study was to assess the effect of subacute treatment with a low dose of atrazine (1,3,5-triazine-2,4-diamine, 6-chloro-N-ethyl-N-(1-methylethyl), an s-triazine herbicide, on endocrine oestrus regulation in gilts. A group of nine gilts (F generation of Swedish Landrace × Large Yorkshire) were treated with 1 mg atrazine/kg body mass daily, mixed to the feed for 19 days before the onset of expected oestrus. Blood samples were obtained by cranial vena cava puncture three times daily at 3-h intervals on five post-treatment days, i.e. before and during oestrus. The serum concentration of oestradiol-17> (E ) was determined by the fluoroimmunochemical method. On Day 2 before the onset of expected oestrus, a significantly lower (P < 0.001) E concentration was measured in the serum of treated gilts (31.25 ± 1.95 and 39.32 ± 1.38 pg/mL) than in the control pigs (51.43 ± 1.29 and 68.59 ± 2.99 pg/mL). In contrast, the E concentration measured in the serum of treated animals was significantly higher (P < 0.001) on the day of the expected onset of oestrus and on the subsequent two days (35.43 ± 1.85, 53.92 ± 1.98 and 60.32 ± 2.35 pg/mL, respectively) than in the control animals (13.52 ± 1.79, 21.53 ± 1.35 and 20.05 ± 1.46 pg/mL, respectively). Insufficient serum E concentration of the treated gilts resulted in a failure of expected oestrus, as indicated also by the state of dioestrus demonstrated by histopathological examination of the uterus.

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“…After ovulation, FSH increases because inhibin secretion is low. Secretion of FSH is high during the luteal phase of the oestrous cycle in pigs, but the magnitude of this increase varies among reported studies: 1-5-2 times higher than the preovulatory nadir in some studies (van der Wiel et al, 1981 ;Hasegawa et al, 1988) compared with an increase of 3-4 times in others (Mukai et al, 1989; Fig. 3).…”

Section: Methodsmentioning

confidence: 99%

Effects of weaning on concentrations of inhibin in follicular fluid and plasma of sows

Trout

Killen²,

Christenson³

et al. 1992

Reproduction

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Summary. Changes in plasma and follicular fluid concentrations of inhibin were examined in sows after weaning at 28\p=n-\32days post partum. From 0 to 48 h after weaning, inhibin concentrations were 200\p=n-\300times higher in follicular fluid from small ( < 4 mm) and medium\p=n-\large( \ m=ge\ 4 mm) follicles than in ovarian venous plasma. Inhibin concentrations increased in follicular fluid from medium\p=n-\large follicles at 24 and 48 h after weaning; concentrations in ovarian venous plasma were positively correlated with the number of medium\p=n-\largefollicles (r= 0\m=.\40) and with ovarian venous plasma concentrations of oestradiol (r= 0\m=.\61). Blood

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Periestrous and Midluteal Time Courses of Circulating LH, FSH, Prolactin, Estradiol-17β and Progesterone in the Domestic Pig

Abstract: Concentrationsof LI-

Cited by 167 publications

References 0 publications

The physiological role of ?-endorphin in porcine ovarian follicles

The physiological role of ?-endorphin in porcine ovarian follicles

Reproductive Disturbance Caused by an S-Triazine Herbicide in Pigs

Effects of weaning on concentrations of inhibin in follicular fluid and plasma of sows

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