Periglomerular Granulomatosis

Localized vasculitis restricted to a specific anatomic site or organ is often histologically indistinguishable from more severe, systemic forms of vasculitis. By definition, localized vasculitis involves blood vessels within a confined vascular distribution or single organ without clinical evidence of generalized inflammation. Important factors that determine treatment and prognosis, in what appears initially to be a localized process, include histopathologic type, organ site, and the presence of systemic inflammatory markers and symptoms. The major issue is whether single organ vasculitis is actually an isolated form of the disease in which case surgical excision is curative, or whether the single organ involvement is simply a precursor of more threatening systemic vasculitis. The Birmingham Vasculitis Activity Score is a valuable tool to identify those patients with concurrent systemic involvement. The physician's recognition of a localized versus systemic vasculitic process is important in terms of making the correct diagnosis, prescribing treatment, and arranging appropriate clinical follow-up.

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Anticytoplasmic Autoantibodies in the Diagnosis and Follow-Up of Wegener's Granulomatosis

Specks¹,

Wheatley²,

McDonald³

et al. 1989

Mayo Clinic Proceedings

247

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Periglomerular Granulomatosis

Cited by 10 publications

References 11 publications

Wegener's granulomatosis

Wegener's granulomatosis

Localized versus systemic vasculitis: Diagnosis and management

Anticytoplasmic Autoantibodies in the Diagnosis and Follow-Up of Wegener's Granulomatosis

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