Perinatal brain group 3 innate lymphoid cells are involved in the formation of murine dural lymphatics
Alba del Rio Serrato,
Borja Latorre Hernández,
Evie Bartl
et al.
Abstract:SummaryThe central nervous system (CNS) contains a pool of innate lymphoid cells (ILCs) of unclear composition and functionality and unknown origin. Here, we demonstrate that group 1 ILCs (inc. ex-ILC3s) and ILC2s are resident cells with low proliferative capacities and subtype specific CNS compartmentalization. We show for the first time that CNS ILC seeding and niche establishment occurs during early life and is initiated by both, ILC progenitors-like PLFZ+PD- 1+cells and lineage committed ILCs. While group … Show more
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