Perinatal exposure to chlordecone, thyroid hormone status and neurodevelopment in infants: The Timoun cohort study in Guadeloupe (French West Indies)

Cordier, Sylvaine; Bouquet, Emilie; Warembourg, Charline; Massart, Catherine; Rouget, Florence; Kadhel, Philippe; Bataille, Henri; Monfort, Christine; Boucher, Olivier; Muckle, Gina; Multigner, Luc

doi:10.1016/j.envres.2015.02.021

Cited by 53 publications

(30 citation statements)

References 39 publications

(49 reference statements)

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“…In 2015, a longitudinal birth-cohort (n = 111) study in Guadeloupe investigated the effects of prenatal and postnatal exposure during breastfeeding. The authors reported that prenatal exposure was associated with increased levels of TSH in boys, while postnatal exposure determined at 3 months was associated with decreased FT3 levels in both genders, and FT4 levels in girls (80).…”

Section: Epidemiological Evidence Of Thyroid Disruptionmentioning

confidence: 99%

“…Because DDT, HCB, and other OCPs have been associated with impaired neurodevelopment and neurocognition in infants and children (60)(61)(62)(63)(64)(65)(66)(67)(68)(69), numerous epidemiological studies have investigated whether these adverse effects could be mediated, at least in part, by disruption of the HPT axis in either pregnant women or newborns (70)(71)(72)(72)(73)(74)(75)(76)(77)(78)(79)(80)(81). An overview of the epidemiological organochlorine studies can be found in Table 1. A Canadian birth-cohort study (n = 101) studied several OCs in pregnant women and observed that p,p ′ -DDE, the main metabolite of DDT, HCB and a constituent of chlordane were negatively associated with total T3 (TT3) levels, and β-HCH with FT4 (78).…”

Section: Epidemiological Evidence Of Thyroid Disruptionmentioning

confidence: 99%

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Pesticides With Potential Thyroid Hormone-Disrupting Effects: A Review of Recent Data

et al. 2019

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Plant Protection Products, more commonly referred to as pesticides and biocides, are used to control a wide range of yield-reducing pests including insects, fungi, nematodes, and weeds. Concern has been raised that some pesticides may act as endocrine disrupting chemicals (EDCs) with the potential to interfere with the hormone systems of non-target invertebrates and vertebrates, including humans. EDCs act at low doses and particularly vulnerable periods of exposure include pre-and perinatal development. Of critical concern is the number of pesticides with the potential to interfere with the developing nervous system and brain, notably with thyroid hormone signaling. Across vertebrates, thyroid hormone orchestrates metamorphosis, brain development, and metabolism. Pesticide action on thyroid homeostasis can involve interference with TH production and its control, displacement from distributor proteins and liver metabolism. Here we focused on thyroid endpoints for each of the different classes of pesticides reviewing epidemiological and experimental studies carried out both in in vivo and in vitro. We conclude first, that many pesticides were placed on the market with insufficient testing, other than acute or chronic toxicity, and second, that thyroid-specific endpoints for neurodevelopmental effects and mixture assessment are largely absent from regulatory directives.

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Section: Epidemiological Evidence Of Thyroid Disruptionmentioning

confidence: 99%

Section: Epidemiological Evidence Of Thyroid Disruptionmentioning

confidence: 99%

Pesticides With Potential Thyroid Hormone-Disrupting Effects: A Review of Recent Data

et al. 2019

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“…In humans, recent epidemiological and toxicological studies have demonstrated that chlordecone is a reproductive and developmental toxicant, an endocrine-disrupting chemical and a neurotoxic. It is also consistently associated with an increase in the risk of prostate cancer (Multigner et al, 2010, 2016; Cordier et al, 2015; Emeville et al, 2015). Chlordecone persists in the environment (Cabidoche et al, 2009; Fernández-Bayo et al, 2013; Devault et al, 2016), and since it bioaccumulates as it moves through the food chain, it was listed in the Persistent Organic Pollutants (POPs) prohibition list of the Stockholm Convention (UNEP/POPS/POPRC.1/INF/6, 2005).…”

Section: Introductionmentioning

confidence: 99%

Microbial Degradation of a Recalcitrant Pesticide: Chlordecone

et al. 2016

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Chlordecone (Kepone®) is a synthetic organochlorine insecticide (C10Cl10O) used worldwide mostly during the 1970 and 1980s. Its intensive application in the French West Indies to control the banana black weevil Cosmopolites sordidus led to a massive environmental pollution. Persistence of chlordecone in soils and water for numerous decades even centuries causes global public health and socio-economic concerns. In order to investigate the biodegradability of chlordecone, microbial enrichment cultures from soils contaminated by chlordecone or other organochlorines and from sludge of a wastewater treatment plant have been conducted. Different experimental procedures including original microcosms were carried out anaerobically over long periods of time. GC-MS monitoring resulted in the detection of chlorinated derivatives in several cultures, consistent with chlordecone biotransformation. More interestingly, disappearance of chlordecone (50 μg/mL) in two bacterial consortia was concomitant with the accumulation of a major metabolite of formula C9Cl5H3 (named B1) as well as two minor metabolites C10Cl9HO (named A1) and C9Cl4H4 (named B3). Finally, we report the isolation and the complete genomic sequences of two new Citrobacter isolates, closely related to Citrobacter amalonaticus, and that were capable of reproducing chlordecone transformation. Further characterization of these Citrobacter strains should yield deeper insights into the mechanisms involved in this transformation process.

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“…In 2009, CLD was added to the list of persistent organic pollutants in the Stockholm Convention, banning its production and use worldwide. Studies suggest exposure to CLD may be linked to higher occurrence of prostate cancer and to impaired cognitive and motor development in young children [1,[12][13][14]. Watershed modelling predicts that CLD will remain in soils for decades or even centuries because of its stability and affinity for soil organic matter, providing a long term source of contamination to the aquatic environment [2].…”

Section: Introductionmentioning

confidence: 99%

Evidence for extensive anaerobic dechlorination and transformation of the pesticide chlordecone (C10Cl10O) by indigenous microbes in microcosms from Guadeloupe soil

et al. 2020

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The historic use of chlordecone (C 10 Cl 10 O) as a pesticide to control banana weevil infestations has resulted in pollution of large land areas in the French West Indies. Although currently banned, chlordecone persists because it adsorbs strongly to soil and its complex bishomocubane structure is stable, particularly under aerobic conditions. Abiotic chemical transformation catalyzed by reduced vitamin B 12 has been shown to break down chlordecone by opening the cage structure to produce C9 polychloroindenes. More recently these C9 polychloroindenes were also observed as products of anaerobic microbiological transformation. To investigate the anaerobic biotransformation of chlordecone by microbes native to the French West Indies, microcosms were constructed anaerobically from chlordecone impacted Guadeloupe soil and sludge to mimic natural attenuation and eletron donor-stimulated reductive dechlorination. Original microcosms and transfers were incubated over a period of 8 years, during which they were repeatedly amended with chlordecone and electron donor (ethanol and acetone). Using LC-MS, chlordecone and degradation products were detected in all the biologically active microcosms. Observed products included monohydro-, dihydro-and trihydrochlordecone derivatives (C 10 Cl 10-n O 2 H n ; n = 1,2,3), as well as "open cage" C9 polychloroindene compounds (C 9 Cl 5-n H 3+n n = 0,1,2) and C10 carboxylated polychloroindene derivatives (C 10 Cl 4-n O 2 H 4+n , n = 0-3). Products with as many as 9 chlorine atoms removed were detected. These products were not observed in sterile (poisoned) microcosms. Chlordecone concentrations decreased in active microcosms as concentrations of products increased, indicating that anaerobic dechlorination processes have occurred. The data enabled a crude estimation of partitioning coefficients between soil and water, showing that carboxylated intermediates sorb poorly and as a consequence may be flushed away, while polychlorinated indenes sorb strongly to soil. Microbial community analysis in microcosms revealed enrichment of anaerobic fermenting and acetogenic microbes possibly involved in anaerobic chlordecone biotransformation. It thus should be possible to

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Perinatal exposure to chlordecone, thyroid hormone status and neurodevelopment in infants: The Timoun cohort study in Guadeloupe (French West Indies)

Cited by 53 publications

References 39 publications

Pesticides With Potential Thyroid Hormone-Disrupting Effects: A Review of Recent Data

Pesticides With Potential Thyroid Hormone-Disrupting Effects: A Review of Recent Data

Microbial Degradation of a Recalcitrant Pesticide: Chlordecone

Evidence for extensive anaerobic dechlorination and transformation of the pesticide chlordecone (C10Cl10O) by indigenous microbes in microcosms from Guadeloupe soil

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