Perinatal Exposure to Low-Dose Bisphenol A Impairs Spatial Learning and Memory in Male Rats

Kuwahara, Rika; Kawaguchi, Shinichiro; Kohara, Yumi; Cui, Haiming; Yamashita, Kimihiro

doi:10.1254/jphs.13093fp

Cited by 49 publications

(27 citation statements)

References 37 publications

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“…Many studies have reported the non-monotonic dose-response of environmental endocrine disruptors such as BPA and diethylstilbestrol (DES) [25,34]. Additionally, it has been suggested that phytoestrogens exert weak estrogenic effects at low concentrations and antiestrogenic effects at high concentrations [21,35].…”

Section: Discussionmentioning

confidence: 99%

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Perinatal exposure to genistein, a soy phytoestrogen, improves spatial learning and memory but impairs passive avoidance learning and memory in offspring

Kohara

Kuwahara

Kawaguchi

et al. 2014

Physiology & Behavior

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This study investigated the effects of perinatal genistein (GEN) exposure on the central nervous system of rat offspring. Pregnant dams orally received GEN (1 or 10 mg/kg/day) or vehicle (1 ml/kg/day) from gestation day 10 to postnatal day 14. In order to assess the effects of GEN on rat offspring, we used a battery of behavioral tests, including the open-field, elevated plus-maze, MAZE and step-through passive avoidance tests. MAZE test is an appetite-motivation test, and we used this mainly for assessing spatial learning and memory. In the MAZE test, GEN groups exhibited shorter latency from start to goal than the vehicle-treated group in both sexes. On the other hand, performances in the step-through passive avoidance test were non-monotonically inhibited by GEN in both sexes, and a significant difference was observed in low dose of the GEN-treated group compared to the vehicle-treated group in female rats. Furthermore, we found that perinatal exposure to GEN did not significantly alter locomotor activity or emotionality assessed by the open-field and elevated-plus maze tests. These results suggest that perinatal exposure to GEN improved spatial learning and memory of rat offspring, but impaired their passive avoidance learning and memory.

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Section: Discussionmentioning

confidence: 99%

“…We used the MAZE test as an estimate of spatial learning and memory as described before [25]. The MAZE apparatus was painted white and consisted of a large compartment (90 × 90 × 50 cm) with an attached goal partition (15 × 15 × 50 cm).…”

Section: Maze Testmentioning

confidence: 99%

Perinatal exposure to genistein, a soy phytoestrogen, improves spatial learning and memory but impairs passive avoidance learning and memory in offspring

Kohara

Kuwahara

Kawaguchi

et al. 2014

Physiology & Behavior

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“…Prenatal (and postnatal) exposure to environmentally relevant doses of BPA through the maternal diet decreased spatial navigation and memory in male deer mice when tested as adults in the Barnes maze [14,15]. Alterations of spatial learning and memory were also reported in male rats [23] and mice [24••] perinatally exposed to BPA. Two human epidemiological studies attempted to correlate gestational BPA exposure with children cognitive responses but reached conflicting conclusions; one study reported significant BPA-associated cognitive impairments [25], while the other failed to find any correlation [26].…”

Section: Behaviormentioning

confidence: 99%

Perinatal exposure to endocrine disruptors: sex, timing and behavioral endpoints

Palanza

Nagel

Parmigiani

et al. 2016

Current Opinion in Behavioral Sciences

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Of the approximately 85,000 chemicals in use, 1000 have been identified as having the ability to disrupt normal endocrine function. Exposure to endocrine disrupting chemicals (EDCs) during critical period in brain differentiation (prenatal and neonatal life) via the mother can alter the course of the development of sexually dimorphic behaviors. Bisphenol A (BPA) is a very high volume chemical used in plastic, resins and other products, and virtually everyone examined has detectable BPA. BPA has estrogenic activity and is one of the most studied EDCs. We review evidence from studies in rodents using dose levels relevant to human exposure. BPA alters behavior and eliminates or in some cases reverses sexually dimorphic behaviors observed in unexposed animals.

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“…Therefore, our results suggest a non-monotonic dose-response effect of NP on spatial learning and memory performance in male rats. In our previous studies, we evaluated the non-monotonic dose-response relationship between perinatal exposure to bisphenol A (BPA) and spatial learning and memory (Kuwahara et al, 2013). BPA is also one of the most commonly encountered environmental endocrine disruptors with a very weak estrogenic activity.…”

Section: Discussionmentioning

confidence: 99%

Oral exposure to low-dose of nonylphenol impairs memory performance in Sprague-Dawley rats

et al. 2015

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-Nonylphenol ethoxylate (NPE) is a non-ionic surfactant, that is degraded to short-chain NPE and 4-nonylphenol (NP) by bacteria in the environment. NP, one of the most common environmental endocrine disruptors, exhibits weak estrogen-like activity. In this study, we investigated whether oral administration of NP (at 0.5 and 5 mg/kg doses) affects spatial learning and memory, general activity, emotionality, and fear-motivated learning and memory in male and female Sprague-Dawley (SD) rats. SD rats of both sexes were evaluated using a battery of behavioral tests, including an appetite-motivated maze test (MAZE test) that was used to assess spatial learning and memory. In the MAZE test, the time required to reach the reward in male rats treated with 0.5 mg/kg NP group and female rats administered 5 mg/kg NP was significantly longer than that for control animals of the corresponding sex. In other behavioral tests, no significant differences were observed between the control group and either of the NP-treated groups of male rats. In female rats, inner and ambulation values for animals administered 0.5 mg/kg NP were significantly higher than those measured in control animals in open-field test, while the latency in the group treated with 5 mg/kg NP was significantly shorter compared to the control group in step-through passive avoidance test. This study indicates that oral administration of a low-dose of NP slightly impairs spatial learning and memory performance in male and female rats, and alters emotionality and fear-motivated learning and memory in female rats only.

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Perinatal Exposure to Low-Dose Bisphenol A Impairs Spatial Learning and Memory in Male Rats

Cited by 49 publications

References 37 publications

Perinatal exposure to genistein, a soy phytoestrogen, improves spatial learning and memory but impairs passive avoidance learning and memory in offspring

Perinatal exposure to genistein, a soy phytoestrogen, improves spatial learning and memory but impairs passive avoidance learning and memory in offspring

Perinatal exposure to endocrine disruptors: sex, timing and behavioral endpoints

Oral exposure to low-dose of nonylphenol impairs memory performance in Sprague-Dawley rats

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