Perinatal unusual rhabdomyoma location – case report and systematic reviews of the literature

Cavalcante, Candice Torres de Melo Bezerra; Pinto, Valdester Cavalcante; Pompeu, Ronald Guedes; Teles, Andrea Consuelo de Oliveira; Bandeira, Jeanne Araújo; Maia, Isabel Cristina Leite; Távora, Fábio; Cavalcante, Marcelo Borges; Zamarian, Ana Cristina Perez; Júnior, Edward Araujo; Branco, Klebia Magalhães Castello

doi:10.1080/14767058.2019.1597044

Cited by 5 publications

(7 citation statements)

References 86 publications

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“…They vary in size from millimeters to a few centimeters and are typically found in the ventricles and inferior vena cava, with about 30 % located in the atrium. The left ventricular myocardium is commonly affected [26]. Our study, in line with the literature, found 75 % of rhabdomyoma cases to be multifocal, with 83 % of tumors in the left ventricle.…”

Section: Discussionsupporting

confidence: 90%

“…Cardiac arrhythmias are common in rhabdomyomas, seen in 16 % to 47 % of cases [26,28] They manifest as ectopic atrial tachycardias, ventricular tachycardias, atrioventricular node dysfunction, and Wolf-Parkinson-White syndrome, depending on tumor location [29]. Typically, as rhabdomyoma size decreases, associated arrhythmias resolve spontaneously [26,30]. Although none of our patients presented with arrhythmia initially, it was detected in four patients during NICU follow-up.…”

Section: Discussionmentioning

confidence: 86%

“…Among our patients diagnosed postnatally, three presented with a cardiac murmur, two with respiratory distress and desaturation, and one with heart failure. Cardiac arrhythmias are common in rhabdomyomas, seen in 16 % to 47 % of cases [26,28] They manifest as ectopic atrial tachycardias, ventricular tachycardias, atrioventricular node dysfunction, and Wolf-Parkinson-White syndrome, depending on tumor location [29]. Typically, as rhabdomyoma size decreases, associated arrhythmias resolve spontaneously [26,30].…”

Section: Discussionmentioning

confidence: 99%

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Neonatal Cardiac Rhabdomyoma: A Single-Center Experience

Kaya,

Akduman,

Dilli

et al. 2024

Z Geburtshilfe Neonatol

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Aim Cardiac rhabdomyoma, known as the most common benign cardiac tumor in childhood, is strongly associated with tuberous sclerosis complex. This study aims to present our single-center experience regarding clinical observations, diagnostic approaches, and treatment modalities for cardiac rhabdomyoma identified during the neonatal period. Patients and Methods In this clinical observational study, we retrospectively assessed the outcomes of 12 newborn patients diagnosed with cardiac rhabdomyoma who were followed up in our neonatal intensive care unit over the past 12 years. Results The mean gestational age of the patients was 38.2±1.6 weeks, with an average birth weight of 3193±314 grams. The mean postnatal age at initial diagnosis was 12.42±15.75 days. Tuberous sclerosis complex was clinically identified in 50% of cases (six patients). Seven infants received everolimus treatment, while three infants underwent clinical monitoring without specific interventions. A significant reduction in cardiac mass size was observed in all surviving patients, leading to their subsequent discharge from the hospital. Conclusion Cardiac rhabdomyomas often undergo spontaneous regression in early childhood. However, in cases with obstructive lesions or arrhythmias, they may present life-threatening consequences. Timely diagnosis, appropriate clinical management, and monitoring are crucial in optimizing outcomes for neonates with cardiac rhabdomyoma.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 86%

Section: Discussionmentioning

confidence: 99%

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Neonatal Cardiac Rhabdomyoma: A Single-Center Experience

Kaya,

Akduman,

Dilli

et al. 2024

Z Geburtshilfe Neonatol

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“…También se debe evaluar el ritmo cardiaco fetal, pues en los raros casos de localización auricular pueden surgir arritmias 9 . El tamaño del tumor debe controlarse durante el embarazo para evaluar el posible crecimiento del tumor, lo que puede deberse a una alta concentración de hormona gestacional que estimula una respuesta hiperplásica e hipertrófica en el tumor 10 .…”

Section: Discussionunclassified

Rabdomiomas cardiacos múltiples, diagnóstico prenatal. Reporte de casos

Carrillo-Lima¹,

Pacheco-López²,

Castro-Santiago³

et al. 2021

ACM

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Los tumores cardiacos son raros en la población infantil, teniendo una incidencia máxima reportada del 0.027% en el diagnóstico prenatal, incrementándose la incidencia en el diagnóstico por necropsia. Los rabdomiomas son los tumores cardiacos más frecuentes, algunos casos pueden asociarse con esclerosis tuberosa. Presentamos el reporte de dos casos en nuestra unidad a los cuales se les realizó diagnóstico prenatal con seguimiento posterior al nacimiento y asociándose uno de ellos a esclerosis tuberosa. Ambos casos recibieron atención en un centro de tercer nivel, sin complicaciones, sin requerir tratamiento quirúrgico, pudiendo ser egresados.

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“…Rhabdomyoma is the most common primary cardiac tumor in infants and children, accounting for more than 60% of primary heart neoplastic lesions [1] . A strong association exists between cardiac rhabdomyomas and tuberous sclerosis (TS), a rare genetic autosomal dominant neurocutaneous disorder, also known as “Bourneville disease,” characterized by multiple hamartomas, predominantly in the central nervous system, such as cortical-subcortical tubers, subependymal nodules, and subependymal giant cells astrocytoma [2 , 3] .…”

Section: Introductionmentioning

confidence: 99%