Perineuronal Net Microscopy: From Brain Pathology to Artificial Intelligence
Mikhail Paveliev,
Anton A. Egorchev,
Foat Musin
et al.
Abstract:Perineuronal nets (PNN) are a special highly structured type of extracellular matrix encapsulating synapses on large populations of CNS neurons. PNN undergo structural changes in schizophrenia, epilepsy, Alzheimer’s disease, stroke, post-traumatic conditions, and some other brain disorders. The functional role of the PNN microstructure in brain pathologies has remained largely unstudied until recently. Here, we review recent research implicating PNN microstructural changes in schizophrenia and other disorders.… Show more
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