Periocular Squamous Cell Carcinoma

Thosani, Maya K; Schneck, Gideon; Jones, Evan

doi:10.1111/j.1524-4725.2007.34115.x

Cited by 28 publications

(35 citation statements)

References 76 publications

(149 reference statements)

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“…There are currently no accepted guidelines for when SLN biopsy is appropriate in periocular SCC 17. On the basis of our current findings that no tumours <18 mm or <T2b were associated with nodal metastasis, it may be reasonable to suggest tumour ≥T2b as criteria for consideration of SLN biopsy or stricter nodal surveillance in patients with eyelid or periocular SCC.…”

Section: Discussionmentioning

confidence: 78%

Impact of AJCC ‘T’ designation on risk of regional lymph node metastasis in patients with squamous carcinoma of the eyelid

et al. 2014

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Section: Discussionmentioning

confidence: 78%

Impact of AJCC ‘T’ designation on risk of regional lymph node metastasis in patients with squamous carcinoma of the eyelid

et al. 2014

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“…Despite increasing ability to differentiate histologically SC from similar appearing benign lesions, the ability to differentiate clinically still presents a significant challenge [2,3,6,[13][14][15]23,25,27,38,45]. The ability to mimic benign lesions such as BCC and chalazia are especially pronounced on the eyelid and it becomes critical to include SC in the differential diagnosis of any ocular disease including benign appearing masses and inflammatory conditions.…”

Section: Discussionmentioning

confidence: 99%

“…Delayed diagnoses with this aggressive epithelial cancer are common and lead to fatal outcomes; many considering it to be the most lethal of all ocular adnexal tumors with mortality rates reported up 50% [2][3][4][5]. Recent efforts have increased clinical awareness and resulted in earlier SC detection; however the ongoing challenge remains to understand the genes and molecular pathways responsible for SC.…”

Section: Introductionmentioning

confidence: 99%

Clinical and Immunohistochemical Features of Sebaceous Carcinoma: Focusing on the p53 Tumor Suppressor

Singh¹,

Weinstock²,

Phelps³

et al. 2017

J Clin Exp Ophthalmol

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Purpose: Considerable focus has recently revealed the importance of p53 in sebaceous carcinoma (SC). This study investigates the utility of p53 as an immunohistochemistry (IHC) marker for differentiating benign and malignant sebaceous tissues and reports the clinical characteristics of patients diagnosed with SC at Mount Sinai Hospital (MSH). Methods:A retrospective chart analysis of 102 patients with SC was performed in addition to a histopathological examination of benign and malignant sebaceous tissues. Immunohistochemistry was performed in 30 cases of SC, 4 cases of sebaceous hyperplasia, 4 cases of sebaceous epitheliomas, and 3 cases of sebaceous adenoma. A separate outpatient cohort was used to compare the clinical and histologic features of eyelid lesions. This included 31 available cases with histologic descriptions of SC. The clinical features of 20 SC cases, 25 BCC cases, and 21 chalazia cases were available and compared from this outpatient cohort. Data collected included age, gender, lesion anatomical location, histopathologic descriptions, and percentage of p53 positive sebocytes. Results:Of the 102 SC cases at MSH, the mean age was 69 years, males composed 58%, and 59% were periorbital or orbital. Positive p53 staining without atypia was reproducibly observed at cell membranes in all cases of sebaceous hyperplasia. Using a standardized p53 grading system used at MSH, the average p53 staining grade for SC and epithelioma was calculated to be 2.3 ± 0.7 and 1 ± 0.7, respectively (p=0.002). An outpatient cohort revealed that 65% of SC was found on the lower eyelid and 84% of BCC was on the upper eyelid. The most common histologic features seen in SC were nuclear atypia (61%) and cytoplasmic vacuoles (55%). Conclusions:This study provides the first comprehensive staining profile of p53 in benign and malignant sebaceous tissues. We also report for the first time that membrane p53 staining was helpful and appeared to be highly specific for identifying sebaceous hyperplasia. p53 staining was also helpful for identifying SC and intraepithelial spreading tumor cells. The clinical and histologic characteristics of specific eyelid lesions in an outpatient setting are also shared. Lastly, this work incorporates the latest research to synthesize IHC recommendations for improving SC detection.

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“…Periocular squamous cell carcinoma (SCC) is an aggressive tumor, characterized by perineural involvement and an overall rate of regional lymph node metastases reported to range from 10% to as high as 20% to 25% [4]. Eyelid SCC is a relatively uncommon but potentially fatal disease.…”

Section: Discussionmentioning

confidence: 99%

Massive Periocular Squamous Cell Carcinoma Engulfing the Globe: A Rare Case Report

Arora

Bhattacharya²,

Adwani³

et al. 2014

Case Reports in Oncological Medicine

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The eyelid tumors are rare neoplasms in head and neck oncological practice. The maximum incidence is after sixty years and most of the tumors are situated in the lower eyelid and medial canthus. A wide range of clinical presentations contribute to a high risk of misdiagnosis. The factors such as very large lesions, incomplete excision, histopathologic features such as poor differentiation, multicentric origin, pagetoid spread, and delayed diagnosis are associated with poor prognosis. Because of different tissues at eyelid level, a variety of tumor types and subtypes can arise, but most of them are carcinomas. A rare case of eyelid carcinoma spreading and engulfing the whole of globe which was treated by orbital exenteration and postoperative radiotherapy is presented with a disease-free follow-up of 10 months which, considering its size, is extremely rare. The early diagnosis and proper treatment of such rare tumors still remain the mainstay to predict favourable prognosis.

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Periocular Squamous Cell Carcinoma

Cited by 28 publications

References 76 publications

Impact of AJCC ‘T’ designation on risk of regional lymph node metastasis in patients with squamous carcinoma of the eyelid

Impact of AJCC ‘T’ designation on risk of regional lymph node metastasis in patients with squamous carcinoma of the eyelid

Clinical and Immunohistochemical Features of Sebaceous Carcinoma: Focusing on the p53 Tumor Suppressor

Massive Periocular Squamous Cell Carcinoma Engulfing the Globe: A Rare Case Report

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