Periodontal pathogens and their role in cardiovascular outcome

Abstract

Aim: Periodontitis has been identified as a moderate but independent risk factor for cardiovascular (CV) disease and progression. The objective of this study (ClinicalTrials.gov Identifier: NCT01045070) was to assess subgingival colonization with selected periodontal pathogens on the occurrence of further adverse CV events in a cohort of CV patients. Methods: The prevalence of severe periodontitis including the detection of 11 periodontal pathogens (Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Prevotella intermedia, Tannerella forsythia, Treponema denticola, P. intermdia, Peptostreptococcus micros, Fusobacterium nucleatum, Campylobacter rectus, Eubacterium nodatum, Eikenella corrodens, Capnocytophaga sputigena, Capnocytophaga gingivalis, Capnocytophaga ochracea; HAIN-Diagnostica ® ) was analysed in 1,002 CV patients The prognostic impact of periodontal pathogens for combined CV endpoint (stroke/TIA, myocardial infarction, CV death, death from stroke) was evaluated after a 3-year follow-up period. Hazard ratios (HRs) were adjusted for established CV risk factors applying Cox regression. Results:In the Kaplan-Meier analysis (log-rank test: p < .001) and Cox regression (HR: 0.545, 95%-CI: 0.387-0.773; p = .001), the decreased occurrence of E. corrodens was shown to be an independent predictor for adverse CV events after 3 years of follow-up. Conclusions:The detection of E. corrodens was associated with a reduced risk of adverse CV events in patients with CV disease. The pathophysiological background underlying this association should be investigated in further studies. K E Y W O R D Sadverse cardiovascular events, cardiovascular disease, E. corrodens, longitudinal cohort study, microbiology, severe periodontitis

The Association of Periodontitis and Peripheral Arterial Occlusive Disease in a Prospective Population-Based Cross-Sectional Cohort Study

“…Interestingly, a longitudinal cohort study recently recruited 1002 patients with cardiovascular disease to assess the impact of subgingival pathogenic colonization on different cardiovascular endpoints, including stroke and myocardial infarction as well as death [ 32 ]. The population in that study was of similar age (69 years), but included more males (74%) and diabetics (36%) when compared with the current cohort.…”

Biodegradable engineered fiber scaffolds fabricated by electrospinning for periodontal tissue regeneration

“…In periodontal diseases, periodontitis is one of the main reasons that destroy the integrity of periodontal system, and has an association with some system disorders, including diabetes, 10 cardiovascular, 11,12 respiratory diseases 13 and adverse pregnancy. 14 Periodontal tissue is a complex with hard and soft tissue, which means it's an intricate system, constituted by root cementum, periodontal ligament (PDL), alveolar bone and gum 15 (Figure 3).…”

Analysis of the Relation between Periodontitis and Chronic Gastritis/Peptic Ulcer: A Cross-Sectional Study Using KoGES HEXA Data

“…Periodontitis has characteristics of a pathological change due to dysbiosis within the oral microbiome [21]. The bacterial infection could affect the oral microbiome, and the complex system of the oral microbiome could, in turn, influence systemic inflammatory diseases [22]. An association between periodontal disease and chronic gastritis/peptic ulcer has been investigated in only a limited number of studies [23][24][25].…”