Periodontal Pathogens are Likely to be Responsible for the Development of Ankylosing Spondylitis

Öğrendik, Mesut

doi:10.2174/1573397111666150522094821

Cited by 7 publications

(9 citation statements)

References 23 publications

(31 reference statements)

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“…It has also been reported that periodontitis is linked to AS, and patients with AS are more likely to suffer periodontitis [9]. Comparing AS patients with healthy people, AS patients have the higher level of anti- Pophyromonas gingivalis [10], again suggesting potential interaction between some specific microbiota with AS.…”

Section: Evidence Of As-microbiome Interactionsmentioning

confidence: 98%

A Possible Role of Intestinal Microbiota in the Pathogenesis of Ankylosing Spondylitis

Yang

Wang

et al. 2016

IJMS

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Ankylosing spondylitis (AS) is a chronic inflammatory disease primarily affecting the sacroiliac joints and the spine, for which the pathogenesis is thought to be a result of the combination of host genetic factors and environmental triggers. However, the precise factors that determine one’s susceptibility to AS remain to be unraveled. With 100 trillion bacteria residing in the mammalian gut having established a symbiotic relation with their host influencing many aspects of host metabolism, physiology, and immunity, a growing body of evidence suggests that intestinal microbiota may play an important role in AS. Several mechanisms have been suggested to explain the potential role of the microbiome in the etiology of AS, such as alterations of intestinal permeability, stimulation of immune responses, and molecular mimicry. In this review, the existing evidence for the involvement of the microbiome in AS pathogenesis was discussed and the potential of intestinal microbiome-targeting strategies in the prevention and treatment of AS was evaluated.

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Section: Evidence Of As-microbiome Interactionsmentioning

confidence: 98%

A Possible Role of Intestinal Microbiota in the Pathogenesis of Ankylosing Spondylitis

Yang

Wang

et al. 2016

IJMS

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“…Oral microbiota (with over 700 species being harbored in the oral cavity) have a role in periodontal disease and in turn, play a contribitory role in periodontitis [44]. Comparing AS patients with healthy people, AS patients have the higher level of anti-Pophyromonas gingivalis, suggesting potential interaction between some specific microbiota and AS [45][46][47][48]. Martinez et al suggested infection was closely related with patients with SpA.…”

Section: Ankylosing Spondylitis (As)mentioning

confidence: 99%

Oral Mucosal Immune Suppression, Tolerance and Silencing: A Mini-Review

Naafs¹

2018

MADOHC

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“…Indeed, oral bacterial DNA and antibodies to P. gingivalis, T. forsythia and P. intermedia have been demonstrated in synovial fluid and the site of inflammation in rheumatoid arthritis [64]. It is also interesting that the medications with an antibacterial action against these species (including levofloxacin and clarithromycin) seem to have a beneficial effect in RA [65].…”

Section: Oral Microbiome In Rheumatoid Arthritismentioning

confidence: 99%

Periodontal Disease and Autoimmunity: What We Have Learned from Microbiome Studies in Rheumatology

Rutter-Locher¹,

Fuggle²,

Orlandi³

et al. 2017

Periodontitis - A Useful Reference

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The oral cavity is home to vast populations of commensal microbial organisms which constitute the 'healthy oral microbiome.' Periodontitis is a destructive, infectious, inflammatory condition affecting the gums. Initially, a biofilm structure develops, causing localized inflammation. This biofilm is then colonized by certain anaerobic bacteria, including the 'red complex' organisms. There is an increasing interest in the communication between these organisms and host immune surveillance, a dialog which may plays an important role in the development of autoimmune diseases. Studies have shown an association between periodontitis and other inflammatory conditions including rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis and systemic lupus. The advent of accessible 16S ribosomal sequencing has led to exciting developments in the characterization of the human microbiome and the ability to study this interaction in more detail. The transmucosal communication between periodontitis and host immunity may provide avenues of discovery regarding the etiology and progression of rheumatic diseases.

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Periodontal Pathogens are Likely to be Responsible for the Development of Ankylosing Spondylitis

Cited by 7 publications

References 23 publications

A Possible Role of Intestinal Microbiota in the Pathogenesis of Ankylosing Spondylitis

A Possible Role of Intestinal Microbiota in the Pathogenesis of Ankylosing Spondylitis

Oral Mucosal Immune Suppression, Tolerance and Silencing: A Mini-Review

Periodontal Disease and Autoimmunity: What We Have Learned from Microbiome Studies in Rheumatology

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