Periodontal regeneration with 0.3% basic fibroblast growth factor (FGF-2) for a patient with aggressive periodontitis: a case report

Yoshinuma, Naoto; Koshi, Ryosuke; Kawamoto, Kiyosumi; Idesawa, Masataka; Sugano, Naoyuki; Sato, Shuichi

doi:10.2334/josnusd.58.137

Cited by 7 publications

(4 citation statements)

References 11 publications

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“…12 Moreover, in a study using individuals with a diagnosis of aggressive periodontitis, in comparison with the control group, it was observed that vertical bone defects had more alveolar bone. 25 Collagen extract can speed up bone development and be employed as an alternative regenerative material for bone production, according to this study's findings of increased expression of BMP4 and FGF2. Whereas FGF2 participates in angiogenesis, which is crucial for periodontal regeneration, BMP4 works to induce osteoblast differentiation.…”

Section: Discussionmentioning

confidence: 81%

The expression of BMP4 and FGF2 in Wistar rats (Rattus norvegicus) post application of gourami fish (Osphronemus goramy) collagen

Prahasanti

Arini²,

Wulan³

et al. 2023

Dent. J.

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Background: Periodontitis is a chronic inflammatory disease of the periodontal tissue that is characterized by alveolar bone resorption. This occurs due to an imbalance of osteoblast and osteoclast during the bone formation and resorption processes. In order to obtain complete regeneration of periodontal tissue, bone grafting is frequently used in periodontal surgical therapy. Although each material has disadvantages, safe graft materials derived from animal sources can be employed as an alternative to bone graft materials. Osteoblast, osteoclast, calcified bone matrix, type I collagen, osteonectin, and hydroxyapatite can all be found in gourami scales, a form of food waste. BMP4 has osteoinduction functions, which are important in bone metabolism. Through angiogenic activity, FGF2 also contributes to periodontal regeneration. Purpose: The aim of the study was to assess the expression of BMP4 and FGF2 after the treatment group had been given gourami fish scale extract. Methods: Thirty-two experimental three-month-old male Wistar rats (150-200g) were randomly divided into four groups: a seven-day control group, a seven-day treatment group, a 14-day control group, and a 14-day treatment group. One mandibular incisor was extracted from each Wistar rat. The post-extraction socket was filled with blood for the control group and collagen extract for the treatment. Results: The one-way ANOVA test showed a significance level of 0.000 (p = <0.05). Conclusion: The expression of BMP4 and FGF2 increased after the application of collagen extract from gourami scales.

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Section: Discussionmentioning

confidence: 81%

The expression of BMP4 and FGF2 in Wistar rats (Rattus norvegicus) post application of gourami fish (Osphronemus goramy) collagen

Prahasanti

Arini²,

Wulan³

et al. 2023

Dent. J.

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show abstract

“…Furthermore, significant alveolar bone development was observed by 6-year postoperative radiograph. 69 Surgical periodontal therapy was shown to influence serum markers as it has decreased serum C-reactive protein levels from 3.09 ± 1.21 mg/L to 1.43 ± 1.21 mg/L, which are usually elevated in AgP. This corresponded with other clinical findings such as mean attachment loss, PI, and PD.…”

Section: Surgical Treatmentmentioning

confidence: 88%

Aggressive Periodontitis Etiology, Pathophysiology, and Treatment: A Recent Review

Missoum¹

2019

International Journal of Experimental Dental Science

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Periodontitis is a microbially driven inflammatory disorder that affects the periodontium and continues to be a major dental health problem worldwide. The aggressive form, formerly known as juvenile periodontitis, is a pathological condition in which rapid destruction of the periodontal tissues and bone occurs at youth, resulting in loss of teeth. Factors such as lifestyle, host response genetic defects, and subgingival microbial consortium are responsible for the progression of the disease. This devastating loss of face esthetics and oral function affects younger patients emotionally, mostly adolescents, and requires costly and invasive treatments such as implants. Fortunately, recent discoveries regarding early diagnostic tools and biomarkers were proven to be effective in controlling aggressive periodontitis (AgP) progression and limiting it at its early stages. Other modified therapies such as bone augmentation and flap surgery has also ameliorated dental clinical parameters and minimized the necessity for dental implants. Each periodontal treatment is assigned depending on the stage and the severity of the disease, and for this reason, early management is crucial. This was achievable, thanks to novel diagnostic methods such as advanced cone-beam computed tomography (CBCT) imaging and high throughput analysis of gingival crevicular fluid (GCF) biomarkers. The review discusses and compares the latest case studies on the use of different periodontal therapies to treat AgP. Recent research about its pathogenesis and etiological factors such as microbial and genetic association is also highlighted.

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“…It has been reported that the clinical parameters and radiographic findings were stable at 6 years after 0.3% bFGF treatment. This may have a higher capacity for new alveolar bone regeneration than other periodontal regenerative therapies [27].…”

Section: Discussionmentioning

confidence: 99%

Periodontal Regeneration Using Gelatin Hydrogels Incorporating Basic Fibroblast Growth Factor

Matsumoto¹

2018

BJSTR

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Periodontal regeneration with 0.3% basic fibroblast growth factor (FGF-2) for a patient with aggressive periodontitis: a case report

Cited by 7 publications

References 11 publications

The expression of BMP4 and FGF2 in Wistar rats (Rattus norvegicus) post application of gourami fish (Osphronemus goramy) collagen

The expression of BMP4 and FGF2 in Wistar rats (Rattus norvegicus) post application of gourami fish (Osphronemus goramy) collagen

Aggressive Periodontitis Etiology, Pathophysiology, and Treatment: A Recent Review

Periodontal Regeneration Using Gelatin Hydrogels Incorporating Basic Fibroblast Growth Factor

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