Periodontal Repair in Dogs: Recombinant Human Bone Morphogenetic Protein‐2 Significantly Enhances Periodontal Regeneration

Sigurðsson, Þórarinn J.; Lee, Michael B.; Kubota, Kohzoh; Turek, Thomas J.; Wozney, John M.; Wikesjö, Ulf M.E.

doi:10.1902/jop.1995.66.2.131

Cited by 287 publications

(254 citation statements)

References 47 publications

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“…The results of this study provide evidence of the safety and technical feasibility of TEB for maxillary sinus floor augmentation and vertical ridge augmentation in agreement with those from earlier animal studies that have indicated that treatment with TEB dose not result in toxicity, significant immunologic reactions, or other serious adverse effects [20][21][22][23] .…”

Section: Figsupporting

confidence: 88%

Tissue engineered bone; Application for implant surgery

Ueda

2011

Inflammation and Regeneration

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Section: Figsupporting

confidence: 88%

Tissue engineered bone; Application for implant surgery

Ueda

2011

Inflammation and Regeneration

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“…BMPs -2, -4, -7 and -12 have all been evaluated for periodontal and peri-implant bone regeneration [67]. From this group of proteins, BMP-2 has been the most studied for bone and periodontal regenerative treatment [101][102][103][104][105][106].…”

Section: Growth Factor Applications For Oral and Periodontal Tissue Ementioning

confidence: 99%

Growth factor delivery for oral and periodontal tissue engineering

Kaigler

Cirelli

Giannobile

2006

Expert Opinion on Drug Delivery

169

153

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The treatment of oral and periodontal diseases and associated anomalies accounts for a significant proportion of the healthcare burden, with the manifestations of these conditions being functionally and psychologically debilitating. Growth factors are critical to the development, maturation, maintenance and repair of craniofacial tissues, as they establish an extracellular environment that is conducive to cell and tissue growth. Tissue-engineering principles aim to exploit these properties in the development of biomimetic materials that can provide an appropriate microenvironment for tissue development. These materials have been constructed into devices that can be used as vehicles for delivery of cells, growth factors and DNA. In this review, different mechanisms of drug delivery are addressed in the context of novel approaches to reconstruct and engineer oral-and tooth-supporting structures, namely the periodontium and alveolar bone.

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“…However, reports of clinical studies have not yet been published. In dental research, BMPs have been used to stimulate periodontal wound healing in dogs, with good result (175,176); again, clinical studies are, as yet, lacking. These animal studies still indicate that BMPs have possibilities for clinical use other than bone repair alone.…”

Section: Other Areas Of Potential Clinical Use Of Bmpsmentioning

confidence: 99%

Bone morphogenetic proteins in human bone regeneration

Groeneveld

Burgér

2000

European Journal of Endocrinology

358

217

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Recently, the first clinical reports on bone regeneration by two recombinant human bone morphogenetic proteins (rhBMPs), BMP-2 and BMP-7 (also named osteogenic protein-1, OP-1) have been published (1-4) . Although both BMPs were able to support bone regeneration, a significant variation in individual response was observed with both proteins. Animal studies and laboratory experiments reveal a number of conditions that influence the osteoinductivity of BMP, such as BMP concentration, carrier properties and influence of local and systemic growth factors and hormones. In this paper, these studies and the clinical reports are reviewed, and the conditions that modulate the BMP-dependent osteoinduction are discussed. The information may provide clues as to how the performance of recombinant human BMP as bone-graft substitute in humans can be improved. European Journal of Endocrinology 142 9-21 BMP and demineralized bone matrixThe history of bone morphogenetic proteins (BMPs) began with the observation that demineralized bone matrix (DBM) is able to induce ectopic bone formation in subcutaneous and intramuscular pockets in rodents (5, 6). This bone induction process has been studied extensively (7-13). Histological and biochemical analyses showed that cartilage appears 5-10 days after implantation of active DBM (8). This cartilage mineralizes by day 7-14 and is subsequently replaced by bone (7-9). After 21 days, haematopoietic bone marrow formation can be observed (12). These cellular events observed after DBM implantation mimic embryonic bone development and normal fracture repair (11). As DBM-related bone formation was observed to occur at ectopic sites, it was assumed that pluripotent mesenchymal cells are attracted to the site of implantation. Isolation of the bone-inducing substance revealed that certain proteins were responsible, which were termed bone morphogenetic proteins (BMPs) or osteogenetic proteins (OPs).The use of DBM in treating bone defects has proven beneficial for bone regeneration both in animals and in humans (14-17). DBM has become widely accepted as a bone-graft substitute in clinical practice (18-22), but its bone inductive capacity has been questioned (23, 24). In several studies, including our own, histology revealed that new bone was generated by osteoconduction rather than osteoinduction (25-27) -that is, bone regeneration occurred by growth of existing host bone on the DBM granules, which acted as a scaffold, rather than by de novo differentiation of bone, independent of pre-existing bone. Lack of inductive properties of DBM may be related to the procedures of production of commercially available DBM, as preservation of osteoinductive activity can be affected by the processing (28-30) or sterilization procedures (31). It is also possible that DBM of human origin, which is preferred for use in clinical practice, is less osteoinductive than DBM derived from animals, which is commonly used in animal studies. Several studies show that DBM from long-lived species such as baboon and human...

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Periodontal Repair in Dogs: Recombinant Human Bone Morphogenetic Protein‐2 Significantly Enhances Periodontal Regeneration

Cited by 287 publications

References 47 publications

Tissue engineered bone; Application for implant surgery

Tissue engineered bone; Application for implant surgery

Growth factor delivery for oral and periodontal tissue engineering

Bone morphogenetic proteins in human bone regeneration

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