Periodontitis affects neurological deficit in acute stroke

Słowik, Joanna; Wnuk, Marcin; Grzech, Kinga; Golenia, Aleksandra; Turaj, Wojciech; Ferens, Antoni; Jurczak, Anna; Chomyszyn‐Gajewska, Maria; Loster, Bartłomiej; Słowik, Agnieszka

doi:10.1016/j.jns.2010.07.012

Cited by 27 publications

(24 citation statements)

References 10 publications

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“…Nevertheless, history of diabetes mellitus also seems to predict poor functional prognosis in our LI patients. A previous study that included 169 ischaemic stroke patients showed that patients with advanced PD had greater neurological deficit on admission as well as poor functional outcome at 3 months compared to those without PD (Slowik et al., ). In PD, it appears that the host overreacts to infectious stimuli by releasing increased amount of inflammatory molecules (i.e., IL‐6 and TNF‐α) that may be disseminate to systemic circulation (Loos, ; Loos, ), which may contribute to pathogenesis of cerebral ischaemia by accelerating brain atheroma plaques progression as well as promoting endothelial dysfunction (Leira, Blanco, Blanco, & Castillo, ).…”

Section: Discussionmentioning

confidence: 99%

“…To date, however, little is known and with conflicting results about the relationship between PD and small vessel ischaemic stroke (i.e., LI) (Leira et al, 2016;Sen et al 2018). On the other hand, ischaemic stroke patients with advanced PD had worse functional outcome at hospital discharge as well as greater neurological deficit compared to those without PD (Slowik et al, 2010).…”

mentioning

confidence: 90%

“…). On the other hand, ischaemic stroke patients with advanced PD had worse functional outcome at hospital discharge as well as greater neurological deficit compared to those without PD (Slowik et al., ).…”

Section: Introductionmentioning

confidence: 99%

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Periodontitis as a risk indicator and predictor of poor outcome for lacunar infarct

Leira

Rodríguez‐Yáñez

Arias

et al. 2018

J Clinic Periodontology

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Aim To investigate the association between periodontitis (PD) and lacunar infarct (LI) as well as to analyse whether PD could be a predictor of poor functional prognosis in patients with LI. Material and Methods Full‐mouth periodontal examination was done in 120 cases (patients with LI) and 157 healthy controls. Demographic, clinical, medical and neurological information were collected from all of them. In addition, a measure of periodontal inflammation and disease activity, namely the periodontal inflamed surface area (PISA), was also calculated for each patient. Poor functional outcome was considered as a modified Rankin Scale >2 at 3 months. Results PD was independently associated with the presence of LI (OR = 3.3, p < 0.001). Poor outcome was observed in 31 patients with LI (25.8%), of which 90.3% had PD. A PISA value ≥727 mm2 was an independent predictor of poor prognosis, after adjusting for clinical confounders (OR = 6.5, p = 0.001). Conclusions PD and LI were associated. Active moderate to severe PD predicted poor prognosis in patients with LI. Further evidence is warranted to confirm our results and investigate potential mechanisms behind this association.

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Section: Discussionmentioning

confidence: 99%

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confidence: 90%

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Periodontitis as a risk indicator and predictor of poor outcome for lacunar infarct

Leira

Rodríguez‐Yáñez

Arias

et al. 2018

J Clinic Periodontology

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“…However, since periodontitis is a chronic infection that leads to inflammation, the appreciation of periodontitis as a risk factor for hypertension has burgeoned lately. There is now evidence that supports periodontitis as an important risk factor for CVD including stroke [70], peripheral artery disease [65, 71], and coronary heart disease [72]. Particularly, the inflammatory response accompanying periodontitis has been proposed as an important factor that may exert adverse effects on the regulation of BP (Table 2).…”

Section: Possible Linking Pathways For the Association Between Hypmentioning

confidence: 99%

Association between Hypertension and Periodontitis: Possible Mechanisms

Leong

Baharin

et al. 2014

The Scientific World Journal

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This review is to examine the current literatures on the relationship between periodontitis and hypertension as well as to explore the possible biological pathways underlying the linkage between these health conditions. Hypertension is one of the major risk factors for cardiovascular diseases. Oxidative stress and endothelial dysfunction are among the critical components in the development of hypertension. Inflammation has received much attention recently and may contribute to a pivotal role in hypertension. Periodontitis, a chronic low-grade inflammation of gingival tissue, has been linked to endothelial dysfunction, with blood pressure elevation and increased mortality risk in hypertensive patients. Inflammatory biomarkers are increased in hypertensive patients with periodontitis. Over the years, various researches have been performed to evaluate the involvement of periodontitis in the initiation and progression of hypertension. Many cross-sectional studies documented an association between hypertension and periodontitis. However, more well-designed prospective population trials need to be carried out to ascertain the role of periodontitis in hypertension.

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“…The association of prestroke acute infectious events, in particular, respiratory tract infections, with increased risk of stroke [5], especially of cardioembolic and atherothrombotic etiology, was reported [2, 6]. Some authors suggest that prestroke infections are related not only to the risk but also to IS severity [7, 8]. On the other hand, stroke severity and lesion location are associated with the risk of in-hospital (post-stroke) infections.…”

Section: Introductionmentioning

confidence: 99%

Infections and Ischemic Stroke Outcome

Grabska

Gromadzka

Członkowska

2011

Neurology Research International

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Background. Infections increase the risk of ischemic stroke (IS) and may worsen IS prognosis. Adverse effects of in-hospital infections on stroke outcome were also reported. We aimed to study the prevalence of pre- and poststroke infections and their impact on IS outcome. Methods. We analysed clinical data of 2066 IS patients to assess the effect of pre-stroke and post-stroke infections on IS severity, as well as short-term (up to 30 days) and long-term (90 days) outcome. The independent impact of infections on poor outcome (death, death/dependency) was investigated by use of logistic regression analysis. The effect of antibiotic therapy during hospitalization on the outcome was also assessed. Results. Pre-stroke infections independently predicted worse short-term outcome. In-hospital infections were associated with worse short-term and long-term IS prognosis. Antibacterial treatment during hospitalization did not improve patients' outcome. Conclusions. Prevention of infections may improve IS prognosis. The role of antibiotic therapy after IS requires further investigations.

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Periodontitis affects neurological deficit in acute stroke

Cited by 27 publications

References 10 publications

Periodontitis as a risk indicator and predictor of poor outcome for lacunar infarct

Periodontitis as a risk indicator and predictor of poor outcome for lacunar infarct

Association between Hypertension and Periodontitis: Possible Mechanisms

Infections and Ischemic Stroke Outcome

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