Periodontitis Deteriorates Metabolic Control in Type 2 Diabetic Goto‐Kakizaki Rats

Abstract

Our results indicated that PD deteriorates metabolic control in diabetes, which emphasizes that PD may play a significant role for the course of diabetes. The GK rat can represent a suitable model for further studies on the association between PD and diabetes.

Efficacy of non-surgical periodontal therapy with adjunct Nd:YAG laser therapy in the treatment of periodontal inflammation among patients with and without type 2 diabetes mellitus: A short-term pilot study

“…It is speculated that NSPT reduces the severity of periodontal infection and decreases the systemic burden of proinflammatory mediators thereby reducing the hyperglycemic state in patients with T2DM [24,25]. However, 6 month follow-up results by Engebretson et al [26] showed no significant improvement glycemic control in patients with T2DM and moderate to advanced periodontal inflammation.…”

Saturated fatty acids enhance osteoclast survival

“…The metabolic syndromes associated with increased level of FFA, diabetes, and atherosclerosis have been demonstrated to be highly related to bone loss ( 9, 13 ). More alveolar bone loss is associated with the Goto-Kakizaki rat, a type 2 diabetes rat ( 22 ), and the Zucker fatty rat, a known model of prediabetes ( 23 ). Lower BMD and rapid bone loss is associated with the advanced aortic calcifi cation, a surrogate marker for atherosclerosis, in postmenopausal women ( 24 ), and a graded association is also found between atherosclerotic vascular calcifi cation and vertebral bone loss ( 25 ).…”

Therapeutic Effect of TSG-6 Engineered iPSC-Derived MSCs on Experimental Periodontitis in Rats: A Pilot Study

“…Specimens were incubated in a desiccator for 48 hours then coated with platinum and examined under a scanning electron microscope (VEGA II Tescan, Cranberry TWP., PA, USA) at an accelerating voltage of 10 kV. Alveolar bone loss was evaluated morphometrically by measuring the distance between the cemento-enamel junction (CEJ) and the palatal alveolar bone crest (ABC) at nine sites [25] from first to second molar for three times. For each animal, alveolar bone loss was defined as the mean of nine measurements.…”