Perioperative Cognitive Decline in the Aging Population

Terrando, Niccolò; Brzeziński, Marek; Degos, Vincent; Eriksson, Lars; Kramer, Joel H.; Leung, Jacqueline M.; Miller, Bruce L.; Seeley, William W.; Vacas, Susana; Weiner, Michael W.; Yaffe, Kristine; Young, William L.; Xie, Zhongcong; Maze, Mervyn

doi:10.4065/mcp.2011.0332

Cited by 155 publications

(117 citation statements)

References 119 publications

(99 reference statements)

Supporting

Mentioning

115

Contrasting

Unclassified

Order By: Relevance

“…Tibial fracture is an established experimental rodent model to study clinically relevant orthopedic procedures (14) and a variety of clinical pathologies ranging from postoperative pain, complex regional pain syndrome, and POCD to bone cancer (15)(16)(17)(18)(19).…”

mentioning

confidence: 99%

Orthopedic surgery modulates neuropeptides and BDNF expression at the spinal and hippocampal levels

Zhang

Barde

Yang

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

Self Cite

View full text Add to dashboard Cite

Pain is a critical component hindering recovery and regaining of function after surgery, particularly in the elderly. Understanding the role of pain signaling after surgery may lead to novel interventions for common complications such as delirium and postoperative cognitive dysfunction. Using a model of tibial fracture with intramedullary pinning in male mice, associated with cognitive deficits, we characterized the effects on the primary somatosensory system. Here we show that tibial fracture with pinning triggers cold allodynia and up-regulates nerve injury and inflammatory markers in dorsal root ganglia (DRGs) and spinal cord up to 2 wk after intervention. At 72 h after surgery, there is an increase in activating transcription factor 3 (ATF3), the neuropeptides galanin and neuropeptide Y (NPY), brain-derived neurotrophic factor (BDNF), as well as neuroinflammatory markers including ionized calcium-binding adaptor molecule 1 (Iba1), glial fibrillary acidic protein (GFAP), and the fractalkine receptor CX3CR1 in DRGs. Using an established model of complete transection of the sciatic nerve for comparison, we observed similar but more pronounced changes in these markers. However, protein levels of BDNF remained elevated for a longer period after fracture. In the hippocampus, BDNF protein levels were increased, yet there were no changes in Bdnf mRNA in the parent granule cell bodies. Further, c-Fos was down-regulated in the hippocampus, together with a reduction in neurogenesis in the subgranular zone. Taken together, our results suggest that attenuated BDNF release and signaling in the dentate gyrus may account for cognitive and mental deficits sometimes observed after surgery.postoperative pain | nerve injury | memory | delirium | neurogenesis

show abstract

mentioning

confidence: 99%

Orthopedic surgery modulates neuropeptides and BDNF expression at the spinal and hippocampal levels

Zhang

Barde

Yang

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

Self Cite

View full text Add to dashboard Cite

show abstract

“…The relationship between comorbid disorders and development of cognitive impairment in the critically ill has not been studied to date. In addition, surgery and anesthesia are associated with the development of cognitive impairments [23]. Postoperative cognitive dysfunction may affect a significant proportion of patients exposed to anesthesia, which may confound the cognitive outcome in surgical ICU patients.…”

Section: Confounding Variablesmentioning

confidence: 99%

Post-intensive care cognitive impairment: questions in mind?

Skrobik

Hopkins

2013

Intensive Care Med

View full text Add to dashboard Cite

“…Highlighting alcohol as a risk factor in Table 1 appeared sufficient to the overall aim of this report because current evidence does not really support this factor as a major thrust of the discussion. 1 Although it is conceivable to associate alcohol abuse with cognitive decline and some reports describe its detrimental role during development 2 or as an intoxicating agent, currently we do not have epidemiologic evidence correlating alcohol abuse with the risk of dementia (ultimately what affected the patient described by Dr Abelson). 3 To further substantiate the controversy regarding alcohol and dementia, other reports even highlight reduced rates of dementia when comparing alcohol drinkers with nondrinkers.…”

Section: Influence Of Alcohol On Perioperative Cognitive Declinementioning

confidence: 99%

“…To the Editor: Terrando et al 1 made an important point in stressing the early delirium and later ongoing aspects of postoperative cognitive decline. However, the possible role of alcohol could and should have been the major thrust of the discussion, not just a passing reference in Table 1.…”

Section: Influence Of Alcohol On Perioperative Cognitive Declinementioning

confidence: 99%

Influence of Alcohol on Perioperative Cognitive Decline

Abelson

2012

Mayo Clinic Proceedings

View full text Add to dashboard Cite

Perioperative Cognitive Decline in the Aging Population

Cited by 155 publications

References 119 publications

Orthopedic surgery modulates neuropeptides and BDNF expression at the spinal and hippocampal levels

Orthopedic surgery modulates neuropeptides and BDNF expression at the spinal and hippocampal levels

Post-intensive care cognitive impairment: questions in mind?

Influence of Alcohol on Perioperative Cognitive Decline

Contact Info

Product

Resources

About