Perioperative Oxygen Toxicity

“…Current studies of the clinical use of hyperoxic management have found various adverse outcomes (16). Oxygen supplementation induces the release of reactive oxygen species, which inhibit the generation of vasodilators such as prostaglandins and nitric oxide.…”

Section: Discussionmentioning

confidence: 99%

Does oxygen therapy increase the resolution rate of primary spontaneous pneumothorax?

Park¹,

Moon²,

Jeon³

et al. 2017

J. Thorac. Dis.

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Background: Patients with small pneumothoraces are usually treated with oxygen therapy. However, evidence that oxygen therapy increases resolution rate is based on small populations with secondary spontaneous pneumothorax. Therefore, this study aimed to confirm whether oxygen therapy increases the resolution rate of primary spontaneous pneumothorax (PSP). Conclusions: Oxygen therapy increases the resolution rate of PSP. However, routine use of oxygen therapy in patients with small pneumothoraces should be considered more carefully. Well-controlled prospective studies are required to confirm the indication of oxygen therapy.

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“…Oxygen can also adversely affect respiratory control, ventilation/perfusion ratios, and hypoxic pulmonary vasoconstriction, as well as cause vasoconstriction of systemic arterioles. 35 Oxygen products from reduced nicotinamide adenine dinucleotide phosphate oxidase also increase inflammation and tissue injury through a complex interaction among neutrophils, macrophages, and platelets. 36 Alveolar recruitment maneuvers allow the anesthesia provider to reduce the F IO 2 yet maintain a higher S pO 2 .…”

Section: Implications For Practicementioning

confidence: 99%

Alveolar Recruitment Maneuvers Under General Anesthesia: A Systematic Review of the Literature

2014

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BACKGROUND:The sigh is a normal homeostatic reflex that maintains lung compliance and decreases atelectasis. General anesthesia abolishes the sigh reflex with rapid onset of atelectasis in 100% of patients. Studies show a strong correlation between atelectasis and postoperative pulmonary complications, raising health-care costs. Alveolar recruitment maneuvers recruit collapsed alveoli, increase gas exchange, and improve arterial oxygenation. There is no consensus in the literature about the benefits of alveolar recruitment maneuvers. A systematic review is necessary to delineate their usefulness. METHODS: The search strategy included utilizing PubMed, CINAHL, the Cochrane Library, the National Guideline Clearinghouse, and all subsequent research reference lists up to January 2014. Inclusion criteria involved studies that compared the use of an alveolar RESPIRATORY CARE • APRIL 2015 VOL 60 NO 4 609 recruitment maneuver with a control group lacking an alveolar recruitment maneuver in adult surgical subjects not suffering from ARDS or undergoing cardiac or thoracic surgeries. RESULTS: Six randomized controlled trials of the 439 studies initially identified achieved a score of > 3 on the Jadad scale and were included in this review. Alveolar recruitment maneuvers consisted of a stepwise increase in tidal volume to a plateau pressure of 30 cm H 2 O, a stepwise increase in PEEP to 20 cm H 2 O, or sustained manual inflations of the anesthesia reservoir bag to a peak inspiratory pressure of 40 cm H 2 O. Subjects in the alveolar recruitment maneuver groups experienced a higher intraoperative P aO 2 with improved lung compliance. Different alveolar recruitment maneuvers were equally effective. There was a significant advantage when alveolar recruitment maneuvers were followed by PEEP application. CONCLUSIONS: Alveolar recruitment maneuvers followed by PEEP should be instituted after induction of general anesthesia, routinely during maintenance, and in the presence of a falling S pO 2 whenever feasible. They allow the anesthesia provider to reduce the F IO 2 while maintaining a higher S pO 2 , limiting the masking of shunts. Utilization of alveolar recruitment maneuvers may reduce postoperative pulmonary complications and improve patient outcomes.

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Perioperative Oxygen Toxicity

Cited by 43 publications

References 59 publications

Can anesthetic-analgesic technique during primary cancer surgery affect recurrence or metastasis?

Can anesthetic-analgesic technique during primary cancer surgery affect recurrence or metastasis?

Does oxygen therapy increase the resolution rate of primary spontaneous pneumothorax?

Alveolar Recruitment Maneuvers Under General Anesthesia: A Systematic Review of the Literature

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