Periostin: a novel prognostic predictor for meningiomas

Abstract

The expression and role of periostin in meningiomas remains unknown. Tissue specimens of 175 convexity meningiomas were immunohistochemically examined with antibodies against periostin and Ki67. The expression levels of periostin and Ki67 were compared among different WHO groups. The role of periostin and Ki67 in postoperative prognosis of meningiomas was also analyzed. Negative (-) expression of Ki67 was observed in 101 (57.7 %) cases of all the surgical tissue samples. The Ki67 expressions differed significantly among the WHO groups (P < 0.001) and correlated positively with the WHO grade (r = 0.673, P < 0.001). Low/negative staining of periostin was observed in 116 (66.3 %) cases. The periostin expressions differed significantly among the WHO groups (P < 0.001). Periostin expression correlated positively with the WHO grade (r = 0.742, P < 0.001). There was a positive correlation between Ki67 expression and periostin (r = 0.513, P < 0.001). Both Ki67 expression and periostin expression was found statistically different between brain invasion tumor and non-invasion tumor (p < 0.001). The recurrence rate and PFS rate in both varied Ki67 expression groups and periostin expression groups was statistically different (P < 0.001). The survival time and PFS time in both varied Ki67 expression groups and periostin expression groups was also statistically different (P < 0.001). Periostin was expressed in tumor stroma of meningiomas. Both periostin and Ki67 may behave as a maker in predicting the grade and prognosis in meningiomas. Drugs that targets periostin aims at reducing invasion of meningioma patients should be further researched.

In situ characterization of stem cells-like biomarkers in meningiomas

“…The analysis of a single marker throughout the consecutive sections along a depth of 32 μm indicated a strong correlation of expression for both adjacent and distal sections of meningioma tissues. Basic analysis locating CSC niches across consecutive sections has been attempted previously in breast cancer tissues [ 80 , 81 ]; however, no correlation of expression was studied. Spearman’s Rho factor indicated a highly significant correlation between the expressions of Vimentin and SSEA4, and the expressions of CD133 and GFAP.…”

Identification of extracellular vesicle-borne periostin as a feature of muscle-invasive bladder cancer

“…Periostin is overexpressed in many human cancers, and high periostin levels have been correlated with tumor proliferation, cell motility and invasion, metastasis, angiogenesis, evasion of apoptosis, clinical stage, and survival outcome [ 9 – 15 ]. Additionally, it has recently been proposed as a biomarker in a number of cancers [ 16 – 18 ]. At the molecular level, periostin activates the PI3K/Akt and/or MAP kinase pathways via interaction with integrin receptors αVβ3 and αVβ5, promoting cell adhesion, motility, and angiogenesis.…”

Molecular neuropathology of brain‐invasive meningiomas

“…All of the above-mentioned processes are regulated partly through transcription factors and modification of signaling pathways. As in other cancers, the PI3K/ AKT pathway has been implicated in meningiomas, with involvement in cell-cell and cell-ECM interaction through integrin signaling [65,99], in the regulation of cytoskeletal integrity [38] and the interplay of proteases and their inhibitors, specifically MMP-9 [88]. Similarly, the focal adhesion kinase (FAK) and its broad downstream effects have been shown to influence migration and invasion after activation through integrins, growth factors, and other ECM components [50,51,71,88,100,101].…”