Periostin Contributes to the Pathogenesis of Atopic Dermatitis by Inducing TSLP Production from Keratinocytes

Shiraishi, Hiroshi; Masuoka, Miho; Ohta, Shoichiro; Suzuki, Shingo; Arima, Kazuhiko; Taniguchi, Kazuto; Aoki, Shigehisa; Toda, Shuji; Yoshimoto, Tomohiro; Inagaki, Nobuya; Conway, Simon J.; Narisawa, Yutaka; Izuhara, Kenji

doi:10.2332/allergolint.10-oa-0297

Cited by 60 publications

(67 citation statements)

References 40 publications

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“…In addition, periostin also induced IL‐25 mRNA expression from NHEK. Periostin, an extracellular matrix protein produced by Th2 cytokine‐stimulated fibroblasts, is known to promote survival and proliferation of epidermal keratinocytes and induce production of thymic stromal lymphopoietin, followed by amplification of allergic skin inflammation . In fact, periostin is highly expressed in lesional skin of AD and CTCL, and correlated with disease severity .…”

Section: Discussionmentioning

confidence: 99%

Interleukin-25 is involved in cutaneous T-cell lymphoma progression by establishing a T helper 2-dominant microenvironment

et al. 2018

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Section: Discussionmentioning

confidence: 99%

Interleukin-25 is involved in cutaneous T-cell lymphoma progression by establishing a T helper 2-dominant microenvironment

et al. 2018

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“…Periostin clearly plays crucial roles in tissue repair. However, in some cases, chronic or superabundant periostin expression can accelerate pathogenesis of tumours (22,23), bronchial asthma (24,25), atopic dermatitis (26,27), polycystic kidney disease, and other fibrotic diseases (28). As recently reported, periostin promotes chronic inflammation by activating nuclear factor kappa B (NF-ĸB) signaling (26,29,30).…”

Section: Discussionmentioning

confidence: 99%

Influence of IL13 on Periostin Secretion by Synoviocytes in Osteoarthritis

Moue

Tajika

Ishikawa

et al. 2017

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“…In addition, periostin has been implicated in atopic conditions such as dermatitis [14, 96] and rhinitis/rhinosinusitis [97]. In allergic skin inflammation, periostin induction after an initial injury contributes to the establishment of sustained chronic inflammation and tissue remodeling [14].…”

Section: Role Of Periostin In Health and Diseasementioning

confidence: 99%

The role of periostin in tissue remodeling across health and disease

Conway

Izuhara

Kudo

et al. 2013

Cell. Mol. Life Sci.

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Periostin, also termed osteoblast-specific factor 2, is a matricellular protein with known functions in osteology, tissue repair, oncology, cardiovascular and respiratory systems, and in various inflammatory settings. However, most of the research to date has been conducted in divergent and circumscribed areas meaning that the overall understanding of this intriguing molecule remains fragmented. Here, we integrate the available evidence on periostin expression, its normal role in development, and whether it plays a similar function during pathologic repair, regeneration, and disease in order to bring together the different research fields in which periostin investigations are ongoing. In spite of the seemingly disparate roles of periostin in health and disease, tissue remodeling as a response to insult/injury is emerging as a common functional denominator of this matricellular molecule. Periostin is transiently upregulated during cell fate changes, either physiologic or pathologic. Combining observations from various conditions, a common pattern of events can be suggested, including periostin localization during development, insult and injury, epithelial–mesenchymal transition, extracellular matrix restructuring, and remodeling. We propose mesenchymal remodeling as an overarching role for the matricellular protein periostin, across physiology and disease. Periostin may be seen as an important structural mediator, balancing appropriate versus inappropriate tissue adaption in response to insult/injury.

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Periostin Contributes to the Pathogenesis of Atopic Dermatitis by Inducing TSLP Production from Keratinocytes

Abstract: Our results suggest that periostin exacerbates the pathogenesis of AD through TSLP production from keratinocytes.

Cited by 60 publications

References 40 publications

Interleukin-25 is involved in cutaneous T-cell lymphoma progression by establishing a T helper 2-dominant microenvironment

Interleukin-25 is involved in cutaneous T-cell lymphoma progression by establishing a T helper 2-dominant microenvironment

Influence of IL13 on Periostin Secretion by Synoviocytes in Osteoarthritis

The role of periostin in tissue remodeling across health and disease

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