Peripapillary vessel density and retinal nerve fiber layer thickness changes in early diabetes retinopathy

Wang, Xiangning; Li, Tingting; Long, Da; Wu, Qiang

doi:10.18240/ijo.2022.09.12

Cited by 11 publications

(11 citation statements)

References 30 publications

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“…They also demonstrated an increased rate of apoptosis in the GCL and inner nuclear layer. Studies have revealed that retinal neurodegeneration may precede microvascular changes of DRP [14,[23][24] . mGCL, mRNFL, and pRNFL thickness reduction are indicators of diabetic retinal neurodegeneration in individuals with type 2 DM without DRP.…”

Section: Resultsmentioning

confidence: 99%

Retinal neurodegeneration in metabolic syndrome: a spectral optical coherence tomography study

Polat¹,

Togac²,

Şahin³

2023

Int J Ophthalmol

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AIM: To evaluate the effects of metabolic syndrome (MetS) on retinal neurodegeneration by optical coherence tomography (OCT). METHODS: Patients diagnosed as MetS were compared with the age and sex-matched healthy control group (CG). Waist circumference measurements, fasting serological biochemical tests, and systemic blood pressures of all participants were evaluated. The MetS group was divided into 3 subgroups according to the number of MetS components: hypertension, diabetes mellitus, dyslipidemia (low-, high-density lipoprotein, hypertriglyceridemia), and visceral obesity findings; 3-component MetS3, 4-component MetS4, and all-component MetS5. All patients underwent complete eye examination and spectral OCT retinal imaging. RESULTS: Totally 58 eyes of 58 patients were included in the MetS group and 63 eyes of 63 age and sex-matched healthy subjects were included in CG. MetS group was composed of 22 subjects in MetS3, 21 subjects in MetS4, and 15 subjects in the MetS5 subgroup. Mean foveal thickness (MetS, 218.7±23.1 µm vs CG, 228.8±21.9 µm, P=0.015), mean inferior (MetS, 283.4±17.0 µm vs CG, 288.7±38.4 µm, P=0.002), superior (MetS, 287.0±18.5 µm vs CG 297.3±17.1 µm, P=0.001), nasal (MetS 287.3±16.7 µm vs CG 297.9±13.9 µm, P=0.000) and temporal (274.5±17.6 µm vs CG 285.6±13.6 µm, P=0.000) thickness in the 3 mm Early Treatment of Diabetic Retinopathy Study (ETDRS) circle was significantly lower in the MetS group. There was no statistically significant difference in the mean inferior, superior, nasal, and temporal thickness of 6 mm ETDRS circle, total macular volume, peripapillary and macular retinal nerve fiber layer, macular ganglion cell layer with inner plexiform layer, and ganglion cell complex. No statistically significant difference was found in these values ??between the MetS3, MetS4, and the MetS5 groups. CONCLUSION: A significant reduction in central macular region thickness in MetS is detected and macular thickness is more susceptible to MetS induced neurodegeneration than peripapillary retinal nerve fiber layer.

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Section: Resultsmentioning

confidence: 99%

Retinal neurodegeneration in metabolic syndrome: a spectral optical coherence tomography study

Polat¹,

Togac²,

Şahin³

2023

Int J Ophthalmol

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“…Yu et al [26] as well as Visser et al [27] have hypothesized that since the papillomacular fibers are located in the temporal retinal quadrant, they may be more affected by the neurodegenerative process in PD. Furthermore, recent studies have suggested that changes in peripapillary RNFL (pRNFL) and peripapillary vessel density (pVD) detected by OCT-A are significant in PD patients [28][29] . As shown by Yang et al [29] the thickness of pRNFL is significantly decreased in PD patients and is correlated with disease severity, while they also show significant alteration in pVD according to disease severity.…”

Section: Discussionmentioning

confidence: 99%

Retinal capillary plexus in Parkinson’s disease using optical coherence tomography angiography

Giachos,

Tsiogka,

Manoli

et al. 2024

Int J Ophthalmol

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AIM: To evaluate the alterations of the retinal microvasculature and foveal avascular zone in patients with Parkinson's disease (PD) using optical coherence tomography angiography (OCT-A). METHODS: A retrospective study of PD patients examined in the Ophthalmology Department of the General Hospital of Athens, “Georgios Gennimatas” from March 2021 to March 2022 was conducted. Totally 44 patients with PD were included and 18 healthy controls were examined, hence a total of 124 eyes were enrolled in the study. The foveal and parafoveal superficial and deep capillary plexus vascular density (fSCP-VD, fDCP-VD, pSCP-VD, pDCP-CD) and foveal avascular zone (FAZ) were quantified with OCTA. Optical coherence tomography (OCT) was used to measure macular thickness. Our statistical analysis was conducted by using a mixed effect linear regression model. RESULTS: After adjustment for age and gender, the mean parafoveal superficial capillary plexus vascular density (pSCP-VD) and mean parafoveal deep capillary plexus vascular density (pDCP-VD) were significantly decreased in individuals with PD (P&#x003C;0.001 in both) by -2.35 (95%CI -3.3, -1.45) and -7.5 (95%CI -10.4, -4.6) respectively. fSCP-VD and fDCP-VD didn't approach statistical significance. The FAZ area and perimeter were significantly decreased (P&#x003C;0.001 in both) by -0.1 mm2 (95%CI -0.13, -0.07) and -0.49 mm2 (95%CI -0.66, -0.32) respectively. Circularity didn't approach statistical significance. Central retinal thickness (CRT) was significantly decreased in individuals with PD (P&#x003C;0.001) by -23.1 μm (95%CI -30.2, -16) and temporal retinal thickness (TRT) was decreased (P=0.025) by -11 μm (95%CI -22, -1.5) while nasal retinal thickness (NRT) only approached statistical significance (P=0.066). CONCLUSION: The mean pSCP-VD, pDCP-VD, CRT and TRT are significantly decreased and FAZ is altered in individuals with PD. These findings can be potentially used as biomarkers for the diagnosis and evaluation of early PD.

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“…Recent studies have also reported the association of capillary vessel density with DR and found that CVD changes may be a useful indicator of DR severity [ 29 , 30 ]. However, the cumulative peripapillary perfusion is largely influenced by large vessels.…”

Section: Discussionmentioning

confidence: 99%

Wide-field swept-source OCTA in the assessment of retinal microvasculature in early-stage diabetic retinopathy

Wang

Cai

et al. 2022

BMC Ophthalmol

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Background To perform a quantitative analysis of retinal microvasculature in patients with early-stage diabetic retinopathy (DR) using wide-field swept-source optical coherence tomography angiography (SS-OCTA). Methods One hundred nineteen eyes of 119 patents (67 eyes with no DR and 52 eyes with mild-moderate nonproliferative diabetic retinopathy (NPDR)) were enrolled in this observational and cross-sectional cohort study, and an age-matched group consisting of 39 eyes of 39 non-diabetic subjects were set as the control. Each participant underwent a full ophthalmic examination, including wide-field SS-OCTA imaging. On OCTA scans (12 mm * 12 mm), the mean perfusion area (PA) and vessel density (VD) were independently measured in all 16 Early Treatment Diabetic Retinopathy Study (ETDRS) sectors. Linear regression analyses were conducted to evaluate the influences of PA. Results In the central ring, there were no significant differences in the average PA and VD among the groups. In the 3 mm radius, the PA and VD of the no DR and mild-moderate NPDR were significantly decreased compared with the control group in superior and inferior quadrants. In the wide-field scans (9 and 12 mm radius), there was no significant difference in average PA and VD between the groups in each sectors (p > 0.05). Regression analysis found that the effect of VD on PA was statistically different (b = 1.311, p < 0.001). Conclusion Wide-field OCTA imaging is useful for evaluating peripheral capillary perfusion in eyes with early-stage DR. Decrease in PA and VD was greater in the S3 and I3 sectors, and reductions in PA and VD were uneven in wide-filed sectors (9 and 12 mm radius).

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Peripapillary vessel density and retinal nerve fiber layer thickness changes in early diabetes retinopathy

Cited by 11 publications

References 30 publications

Retinal neurodegeneration in metabolic syndrome: a spectral optical coherence tomography study

Retinal neurodegeneration in metabolic syndrome: a spectral optical coherence tomography study

Retinal capillary plexus in Parkinson’s disease using optical coherence tomography angiography

Wide-field swept-source OCTA in the assessment of retinal microvasculature in early-stage diabetic retinopathy

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