Peripheral and autonomic nerve involvement in primary amyloidosis associated with uncontrollable diarrhoea and steatorrhoea

French, J. M.; Hall, Gilbert; Parish, D. J.; Smith, William Thomas Lingwood

doi:10.1016/0002-9343(65)90052-5

Cited by 73 publications

(8 citation statements)

References 19 publications

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“…From consideration of these 3 1 patients with neuropathy and primary amyloidosis and review of previously reported cases [4,6,7,16,17,25,26,[31][32][33], a fairly consistent type of peripheral neuropathy and natural history emerges. The typical patient is a man in the late decades of life who has a sensorimotorautonomic neuropathy without systemic involvement or, in approximately half of the cases, with cardiac, hematological, renal, o r gastrointestinal dysfunction.…”

Section: Discussionmentioning

confidence: 99%

The natural history of peripheral neuropathy in primary systemic amyloidosis

Kelly

Kyle

O’Brien

et al. 1979

Annals of Neurology

171

110

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The records of 31 patients with primary systemic amyloidosis and peripheral neuropathy seen during a 17-year period were analyzed to define the natural history of the neuropathy. Patients tended to be older men with a painful, distal, symmetrical sensorimotor neuropathy and prominent autonomic features. Loss of pain and temperature sensation was frequently more striking than loss of mechanoreception. Renal, cardiac, hematological, and gastrointestinal dysfunction often overshadowed the neuropathy. Clinical, neurophysiological, and histopathological studies pointed to axonal degeneration with predominant but not exclusive involvement of small myelinated and unmyelinated fibers. The neuropathy was progressive in all patients with or without treatment, but death was typically due to supervening medical complications.

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Section: Discussionmentioning

confidence: 99%

The natural history of peripheral neuropathy in primary systemic amyloidosis

Kelly

Kyle

O’Brien

et al. 1979

Annals of Neurology

171

110

View full text Add to dashboard Cite

show abstract

“…Twenty-five cases were presumed to be of the pericollagen type (Randall, 1933;Pearson, Rice, and Dickens, 1941;Golden, 1945;Findley and Adams, 1948;Andrade, 1952;Clausen, cited by Cooley, 1953;Cooley, 1953;Lubarsch, cited by Cooley, 1953;Steinhaus, cited by Cooley, 1953;Golden, 1954;Perloff, 1954;Shnider and Burka, 1955;Intriere and Brown, 1956;Korelitz and Spindell, 1956;Heitzman, Heitzman, and Elliott, 1962;Liske, Chou, and Thompson, 1963;Akbarian and Fenton, 1964;Brody et al, 1964;Massachusetts General Hospital Case Records, 1964;Casad and Bocian, 1965;French, Hall, Parish, and Smith, 1965;Long, Mahony, and Jewell, 1965). Blood vessels were involved in all these 25 cases and the muscularis in 22.…”

Section: Discussionmentioning

confidence: 99%

Deposition of amyloid in the gastrointestinal tract.

Gilat¹,

Revach²,

Sohar³

1969

Gut

136

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“…Bottom Left, Small portion of remnant of un¬ myelinated fiber cluster from sural nerve of case III. 5, kinship 99-67, showing what may have been a former site of an unmyelinated fiber( 20,800). Bottom Right, Collagen fibrils (CF) and amyloid fibrils (AF) ( 63,000).…”

mentioning

confidence: 99%