2021
DOI: 10.1016/j.msard.2021.103019
|View full text |Cite
|
Sign up to set email alerts
|

Peripheral blood B cell subset ratios and expression levels of B cell-associated genes are altered in benign multiple sclerosis

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1

Citation Types

1
3
0

Year Published

2021
2021
2025
2025

Publication Types

Select...
8

Relationship

0
8

Authors

Journals

citations
Cited by 8 publications
(4 citation statements)
references
References 34 publications
1
3
0
Order By: Relevance
“…We have discovered that compared with non‐MS controls, BLNK protein levels in people with MS are significantly lower in all circulating B cells analyzed, particularly the IgA + , IgG1 + and IgG2 + subsets we have identified to play a novel role in MS pathogenesis and their response to alemtuzumab. Our observation is supported by a recent study showing lower BLNK mRNA levels in patients with benign MS compared with healthy controls 26 . Lower BLNK levels is likely to result in perturbed B‐cell receptor signaling 27 and/or B‐cell survival 28 in MS.…”
Section: Discussionsupporting
confidence: 87%
See 1 more Smart Citation
“…We have discovered that compared with non‐MS controls, BLNK protein levels in people with MS are significantly lower in all circulating B cells analyzed, particularly the IgA + , IgG1 + and IgG2 + subsets we have identified to play a novel role in MS pathogenesis and their response to alemtuzumab. Our observation is supported by a recent study showing lower BLNK mRNA levels in patients with benign MS compared with healthy controls 26 . Lower BLNK levels is likely to result in perturbed B‐cell receptor signaling 27 and/or B‐cell survival 28 in MS.…”
Section: Discussionsupporting
confidence: 87%
“…Our observation is supported by a recent study showing lower BLNK mRNA levels in patients with benign MS compared with healthy controls. 26 Lower BLNK levels is likely to result in perturbed B-cell receptor signaling 27 and/or B-cell survival 28 in MS. It may also indicate a defect in immune regulation as mice deficient in BLNK have impaired IL-10 production from B10 cells and develop more severe experimental autoimmune encephalomyelitis.…”
Section: Discussionmentioning
confidence: 99%
“…A few cases of homozygous BLNK mutations have been described, all leading to near-total absence of circulating B-cells and severe hypo- or agammaglobulinemia ( 11 , 13 16 ). A dysfunction of BLNK has also been associated with autoimmune diseases, such as multiple sclerosis ( 17 , 18 ), or rheumatoid arthritis which is known to be associated with LGL leukemia ( 19 ).…”
Section: Discussionmentioning
confidence: 99%
“…Data from our previous microarray study were used to identify candidate genes (10). In that study, RNA expression profiles of PBMCs of 5 RRMS, 6 benign MS, and 5 healthy donors were determined with the Sureprint G3 Human Gene Expression V3 microarray (MA) system.…”
Section: Target Genes Identification and Rna Isolationmentioning
confidence: 99%