Peripheral blood inflammatory markers in early Parkinson’s disease

Kim, Ryul; Kim, Han Joon; Kim, Aryun; Jang, Mijung; Kim, Ahro; Kim, Yoon; Yoo, Dallah; Im, Jin Hee; Choi, Ji Hyun; Jeon, Beomseok

doi:10.1016/j.jocn.2018.10.079

Cited by 79 publications

(64 citation statements)

References 28 publications

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“…Interestingly, a correlation between IL-10 levels and gastrointestinal symptoms in the early stage of PD was also recently reported, thus, reflecting a protective response against inflammatory processes associated with the disease [ 85 ].…”

Section: Il-10 In Brain Diseasesmentioning

confidence: 87%

The Regulatory Role of IL-10 in Neurodegenerative Diseases

2020

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IL-10, an immunosuppressive cytokine, is considered an important anti-inflammatory modulator of glial activation, preventing inflammation-mediated neuronal degeneration under pathological conditions. In this narrative review, we summarize recent insights about the role of IL-10 in the neurodegeneration associated with neuroinflammation, in diseases such as Multiple Sclerosis, Traumatic Brain Injury, Amyotrophic lateral sclerosis, Alzheimer’s Disease, and Parkinson’s Disease, focusing on the contribution of this cytokine not only in terms of protective action, but also as possibly responsible for clinical worsening. The knowledge of this double face of the same coin, regarding the biological role of the IL-10, could aid the development of targeted therapies useful for limiting neurodegenerative processes.

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Section: Il-10 In Brain Diseasesmentioning

confidence: 87%

The Regulatory Role of IL-10 in Neurodegenerative Diseases

2020

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“…Cytokines such as IL-2, IL-4, IL-10, IL-6, TNF-α, and IFN-γ are increased in the peripheral blood of patients with PD ( 26 ). In addition, Kim et al showed that IL-10 concentrations are positively correlated with non-motor symptoms in PD ( 27 ). Up to now, studies on inflammation in PD have mainly focused on the detection of pro-inflammatory cytokines, such as TNF-α, IL-1β, IL-6, and IFN-γ, and anti-inflammatory cytokines, such as IL-10 and TGF-β, in the cerebrospinal fluid and peripheral blood of PD patients.…”

Section: Discussionmentioning

confidence: 99%

Imbalance of Circulating Tfh/Tfr Cells in Patients With Parkinson's Disease

et al. 2020

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Background: Follicular helper T (Tfh) cells and follicular regulatory T (Tfr) cells are essential for B cell differentiation, germinal center formation, and humoral immune responses. Immunity and inflammation have been thought to be involved in Parkinson's disease (PD). In this study, we aimed to identify whether circulating Tfh and Tfr (cTfh and cTfr) cells contribute to PD. Methods: Thirty-nine PD patients and 26 health controls (HCs) were enrolled. The numbers of cTfh (CD4 + CXCR5 + PD-1 + ) cells and cTfr (CD4 + CXCR5 + CD25 hi CD127 low ) cells were analyzed via flow cytometry. The serum concentrations of interleukin (IL)-4, IL-10, IL-21, and transforming growth factor (TGF)-β were examined by cytometric bead array. Results: The percentage of cTfh cells among CD4 + T cells in PD patients was significantly higher than that in HCs [3.68% (2.64–5.70%) vs. 1.94% (1.32%−2.99%), P < 0.001], while the percentage of cTfr cells among CD4 + T cells in PD patients was slight decreased but without significance [1.05% (0.62–1.54%) vs. 1.3% (0.63–1.90%), P > 0.05]. The percentage of CD19 + B cells in peripheral blood mononuclear cells was significantly lower in PD patients than in HCs [5.35% (4.13–9.38%) vs. 8.68% (5.61–12.93%), P = 0.014]. The serum concentrations of IL-4, IL-10, IL-21, and TGF-β in PD patients did not differ significantly from those in HCs ( P > 0.05). There was a positive trend of the correlation between the number of cTfh and the serum IL-4 concentrations in PD patients ( P = 0.032, r = 0.353). There was a positive trend of the correlation between the number of cTfr and the serum IL-10 concentrations in PD patients ( P = 0.047, r = 0.328), A positive trend of the correlation were found for the serum concentration of IL-21 with H-Y stage ( r = 0.356, P = 0.026) and UPDRS-III score ( r = 0.347, P = 0.030). Conclusions: These results indicate that an imbalance of cTfh and cTfr cells may be involved in the chronic progression of PD, and IL-21 may be a biomarker for monitoring the severity of this disease.

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“…Cytokines such as IL-2, IL-4, IL-10, IL-6, TNF-α, and IFN-γ are increased in the peripheral blood of patients with PD [26]. In addition, Kim et al showed that IL-10 concentrations are positively correlated with nonmotor symptoms in PD [27]. Up to now, studies on in ammation in PD have mainly focused on the detection of pro-in ammatory cytokines, such as TNF-α, IL-1β, IL-6, and IFN-γ, and anti-in ammatory cytokines, such as IL-10 and TGF-β, in the cerebrospinal uid and peripheral blood of PD patients.…”

Section: Discussionmentioning

confidence: 99%

Imbalance of circulating Tfh/Tfr cells in patients with Parkinson’s disease

Zhao

Jin

Zheng

et al. 2020

Preprint

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Background: Follicular helper T (Tfh) cells and follicular regulatory T (Tfr) cells are essential for B cell differentiation, germinal center formation, and humoral immune responses. Immunity and inflammation have been thought to be involved in Parkinson’s disease (PD). In this study, we aimed to identify whether circulating Tfh and Tfr (cTfh and cTfr) cells contribute to PD.Methods: Thirty-nine PD patients and 26 health controls (HCs) were enrolled. The numbers of cTfh (CD4+CXCR5+PD-1+) cells and cTfr (CD4+CXCR5+CD25hiCD127low) cells were analyzed via flow cytometry. The serum concentrations of interleukin (IL)-4, IL-10, IL-21, and transforming growth factor (TGF)-β were examined by cytometric bead array.Results: The percentage of cTfh cells among CD4+ T cells in PD patients was significantly higher than that in HCs [3.68% (2.64%–5.70%) vs 1.94% (1.32%–2.99%), P<0.001], while the percentage of cTfr cells among CD4+ T cells in PD patients was slight decreased but without significance [1.05% (0.62%–1.54%) vs 1.3% (0.63%–1.90%), P>0.05]. The percentage of CD19+ B cells in peripheral blood mononuclear cells was significantly lower in PD patients than in HCs [5.35% (4.13%–9.38%) vs 8.68% (5.61%–12.93%), P=0.014]. The serum concentrations of IL-4, IL-10, IL-21, and TGF-β in PD patients did not differ significantly from those in HCs (P>0.05). However, significant positive correlations were found for the serum concentration of IL-21 with H-Y stage (r=0.356, P=0.026) and UPDRS-III score (r=0.347, P=0.030).Conclusions: These results indicate that an imbalance of cTfh and cTfr cells may be involved in the chronic progression of PD, and IL-21 may be a biomarker for monitoring the severity of this disease.

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Peripheral blood inflammatory markers in early Parkinson’s disease

Cited by 79 publications

References 28 publications

The Regulatory Role of IL-10 in Neurodegenerative Diseases

The Regulatory Role of IL-10 in Neurodegenerative Diseases

Imbalance of Circulating Tfh/Tfr Cells in Patients With Parkinson's Disease

Imbalance of circulating Tfh/Tfr cells in patients with Parkinson’s disease

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