Peripheral blood monocyte activation during coronary artery bypass grafting with or without cardiopulmonary bypass

Wehlin, Lena; Vedin, Jenny; Vaage, Jarle; Lundahl, Joachim

doi:10.1080/14017430410004623

Cited by 27 publications

(23 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On the contrary, in a recently published RCT to investigate the impact of CABG on peripheral monocytes and to evaluate the additional effect of CPB, Wehlin et al 20 demonstrated that during surgery there was a selective decrease in the proportion of CD16+/CD14+ monocytes compared to total monocytes. These had returned to preoperative values 24 hours after surgery, while the total number of monocytes had increased more than 100%.…”

Section: Resultsmentioning

confidence: 97%

See 1 more Smart Citation

Impact of Off-Pump Coronary Artery Bypass Surgery on Systemic Inflammation: Current Best Available Evidence

2007

View full text Add to dashboard Cite

The systemic inflammatory response after coronary artery bypass grafting using cardiopulmonary bypass (CPB) contributes substantially to postoperative organ dysfunction and coagulation disorders. Important features of this inflammatory reaction include the activation of complement and leukocytes, the release of proinflammatory cytokines, alterations in the metabolism of nitric oxide, and an increase in the production of oxygen-free radicals, which in some cases may lead to oxidant stress injury. Several strategies including the use of steroids, use of aprotinin, heparin-coated CPB circuits, and hemofiltration have been reported to reduce the inflammatory reaction induced by CPB and its consequences. A more radical and effective way of counteracting the effects of the inflammatory reaction and oxidative stress may be the omission of CPB itself. The development and application of off-pump coronary artery bypass (OPCAB) technology has largely been driven by this theme of avoiding systemic inflammatory reaction to decrease the incidence and/or severity of adverse outcomes. This review article discusses the influence of cardiopulmonary bypass on systemic inflammation and attempts to evaluate the current best available evidence on the impact of OPCAB on systemic inflammation.

show abstract

Section: Resultsmentioning

confidence: 97%

“…Serum levels of MCP‐1 decreased during surgery as did soluble CD14, both with increased levels again the day after surgery. Based on these findings, Wehlin et al 20 concluded that the inflammation caused by the surgery procedure per se probably surpasses the impact of the CPB on circulating blood monocytes.…”

Section: Resultsmentioning

confidence: 99%

Impact of Off-Pump Coronary Artery Bypass Surgery on Systemic Inflammation: Current Best Available Evidence

2007

View full text Add to dashboard Cite

show abstract

“…This drop could be explained by the selective entrapment of activated myeloid cells on the surfaces of CPB circuites. Indeed, such selective decrease, particularly population of CD16/CD14 + monocytes during "on-pump" surgery, was reported by Wehlin et al (19).…”

Section: Discussionmentioning

confidence: 91%

Expression of an Activated Form of Integrin β2 Chain CD18 in Cardiac Surgical Operations

Kudlová

Koláčková

Kuneš

et al. 2007

Acta Med. (Hradec Kralove, Czech Repub.)

View full text Add to dashboard Cite

Summary: Background: Myeloid cells are extensively activated in patients undergoing cardiosurgical operations. It is supposed that this activation is more profound in patients operated with cardiopulmonary bypass (CPB) ("on-pump") in comparison with patients operated without CPB ("off-pump"). Aims: To evaluate changes in the expression of a novel activation marker expressed on myeloid cells recognized by MEM-148 antibody. Patients and Methods: The expression of MEM-148 positive myeloid cells was evaluated by flow cytometry in 40 patients who underwent coronary artery bypass surgery (CABG) randomly assigned to "on-pump" or "off-pump" technique. Results: The relative and absolute number of MEM-148 positive myeloid cells is significantly diminished during "on-pump" surgery. A significant increase in their number in postoperative period in both "on-pump" and "off-pump" patients was found. There were no significant differencies between "on-pump" and "off-pump" patients. Conclusions: The very trauma of surgery seems to be more relevant in starting on activation of myeloid cells them CPB itself.

show abstract

“…Previous studies have demonstrated activation of monocyte functions during CPB 12,25 . The activation of monocytes is naturally associated with altered membrane molecule expression and enhanced cytokines production.…”

Section: Discussionmentioning

confidence: 99%

Interferon gamma receptor expression on granulocytes of cardiac surgical patients is modulated differently by the type of cardiopulmonary bypass used

et al. 2011

View full text Add to dashboard Cite

show abstract

Peripheral blood monocyte activation during coronary artery bypass grafting with or without cardiopulmonary bypass

Cited by 27 publications

References 13 publications

Impact of Off-Pump Coronary Artery Bypass Surgery on Systemic Inflammation: Current Best Available Evidence

Impact of Off-Pump Coronary Artery Bypass Surgery on Systemic Inflammation: Current Best Available Evidence

Expression of an Activated Form of Integrin β2 Chain CD18 in Cardiac Surgical Operations

Interferon gamma receptor expression on granulocytes of cardiac surgical patients is modulated differently by the type of cardiopulmonary bypass used

Contact Info

Product

Resources

About