Peripheral CD4 T-Cell Depletion Is Not Sufficient to Prevent Ischemic Acute Renal Failure

Faubel, Sarah; Ljubanović, Danica Galešić; Poole, Brian; Dursun, Belda; He, Zhibin; Cushing, Susan; Somerset, Hilary; Gill, Ronald G.; Edelstein, Charles L.

doi:10.1097/01.tp.0000173396.07368.55

Cited by 50 publications

(38 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…TCRαβ deficient mice had significantly improved renal function with reduced TNF-α and IL-6 production after IRI, while TCRγδ deficient mice only presented slight amelioration [60]. While initially another group failed to observe a role of TCR in renal IRI [61], the importance of TCR in kidney IRI was confirmed by careful knockout and antibody depletion studies [62].…”

Section: Different Roles Of T Cell Subsets In Irimentioning

confidence: 55%

Ischemia–reperfusion and immediate T cell responses

Huang¹,

Rabb²,

Womer³

2007

Cellular Immunology

135

View full text Add to dashboard Cite

Section: Different Roles Of T Cell Subsets In Irimentioning

confidence: 55%

Ischemia–reperfusion and immediate T cell responses

Huang¹,

Rabb²,

Womer³

2007

Cellular Immunology

135

View full text Add to dashboard Cite

“…Rag1 -/-mice lack T and B cells and are not protected from AKI induced by ischemia (55,58). Multiple groups have detected no difference in serum creatinine 24 hours after IRI in mice with depletion of either TCRαβ or TCRγδ (55,59,60), although some have found reduced structural damage (60,61) and/or improved survival and lower serum creatinine (60) at later time points after reperfusion.…”

Section: Figurementioning

confidence: 99%

Cellular pathophysiology of ischemic acute kidney injury

Bonventre¹,

Yang²

2011

J. Clin. Invest.

1,639

1,604

View full text Add to dashboard Cite

“…For all procedures, mice were anesthetized with IP Avertin (2,2,2-tribromoethanol; Aldrich, Milwaukee, WI), a midline incision was made, and the renal pedicles were identified. In the ischemic ARF group, both renal pedicles were clamped for 22 min (23,24). In the unilateral ischemia model, the left renal pedicle was clamped for 22 min.…”

Section: Surgical Protocolmentioning

confidence: 99%

Acute Renal Failure after Bilateral Nephrectomy Is Associated with Cytokine-Mediated Pulmonary Injury

Hoke¹,

Douglas²,

Klein³

et al. 2007

Journal of the American Society of Nephrology

Self Cite

276

275

View full text Add to dashboard Cite

Clinical studies demonstrate that acute renal failure (ARF) is associated with increased mortality, which may be due to pulmonary complications. ARF may affect the lung via increased renal production or impaired clearance of mediators of lung injury, such as proinflammatory cytokines. Bilateral nephrectomy is a method to examine directly the deleterious systemic effects of absent renal clearance in ARF without the confounding effects that are associated with ischemia-reperfusion injury (e.g., ischemic ARF) or systemic toxicity (e.g., cisplatin-induced ARF). This study contrasts the effects of ischemic ARF and bilateral nephrectomy on serum cytokines and lung injury. It demonstrates that the acute absence of kidney function after both ischemic ARF and bilateral nephrectomy is associated with an increase in multiple serum cytokines, including IL-6 and IL-1␤, and that the cytokine profiles were distinct. Lung injury after ischemic ARF and bilateral nephrectomy was similar and was characterized by pulmonary vascular congestion and neutrophil infiltration. For investigation of the role of proinflammatory cytokines in pulmonary injury after ARF, the anti-inflammatory cytokine IL-10 was administered before bilateral nephrectomy. IL-10 treatment improved pulmonary architecture and was associated with a reduction in inflammatory markers, including bronchoalveolar lavage fluid total protein, pulmonary myeloperoxidase activity (a biochemical marker of neutrophils), and the chemokine macrophage inflammatory protein 2. These data demonstrate for the first time that the acute absence of kidney function results in pulmonary injury independent of renal ischemia and highlight the critical role of the kidney in the maintenance of serum cytokine balance and pulmonary homeostasis.

show abstract

Peripheral CD4 T-Cell Depletion Is Not Sufficient to Prevent Ischemic Acute Renal Failure

Abstract: Ischemic ARF can occur in the absence of classical T-cell function. The evaluation of other inflammatory mediators (e.g., macrophages or NK cells) as a source of IL-18 and mediator of ischemic ARF warrants further investigation.

Cited by 50 publications

References 48 publications

Ischemia–reperfusion and immediate T cell responses

Ischemia–reperfusion and immediate T cell responses

Cellular pathophysiology of ischemic acute kidney injury

Acute Renal Failure after Bilateral Nephrectomy Is Associated with Cytokine-Mediated Pulmonary Injury

Contact Info

Product

Resources

About