Peripheral helper T cells in human diseases

Zou, Xueyang; Huo, Feifei; Sun, Lulu; Huang, Jing

doi:10.1016/j.jaut.2024.103218

Cited by 4 publications

(2 citation statements)

References 100 publications

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“…The underlying hypothesis in these studies is that there are a finite number of cell states and transcriptional programmes that define responses to different stimuli, rather than the possibility that each inflammatory challenge induces a distinct response. There is some encouraging evidence for this, such as circulating Tph cells across IMIDs [ 87 ] and shared fibroblast states across inflamed tissues [ 76 ], but a comprehensive catalogue of these states is lacking. Defining these states has the potential to clarify shared qualities across IMIDs.…”

Section: Discussionmentioning

confidence: 99%

Leveraging Multi-Tissue, Single-Cell Atlases as Tools to Elucidate Shared Mechanisms of Immune-Mediated Inflammatory Diseases

McLean,

Reynolds,

Pratt

2024

Biomedicines

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The observation that certain therapeutic strategies for targeting inflammation benefit patients with distinct immune-mediated inflammatory diseases (IMIDs) is exemplified by the success of TNF blockade in conditions including rheumatoid arthritis, ulcerative colitis, and skin psoriasis, albeit only for subsets of individuals with each condition. This suggests intersecting “nodes” in inflammatory networks at a molecular and cellular level may drive and/or maintain IMIDs, being “shared” between traditionally distinct diagnoses without mapping neatly to a single clinical phenotype. In line with this proposition, integrative tumour tissue analyses in oncology have highlighted novel cell states acting across diverse cancers, with important implications for precision medicine. Drawing upon advances in the oncology field, this narrative review will first summarise learnings from the Human Cell Atlas in health as a platform for interrogating IMID tissues. It will then review cross-disease studies to date that inform this endeavour before considering future directions in the field.

show abstract

Section: Discussionmentioning

confidence: 99%

Leveraging Multi-Tissue, Single-Cell Atlases as Tools to Elucidate Shared Mechanisms of Immune-Mediated Inflammatory Diseases

McLean,

Reynolds,

Pratt

2024

Biomedicines

View full text Add to dashboard Cite

show abstract

“…The underlying hypothesis in these studies is that there are a finite number of cell states and transcriptional programs that define responses to different stimuli, rather than the possibility that each inflammatory challenge induces a distinct response. There is some encouraging evidence for this such as circulating Tph cells across IMIDs [86] and shared fibroblast states across inflamed tissues [76], but a comprehensive catalogue of these states is lacking. Defining these states has the potential to clarify shared qualities across IMIDs.…”

Section: Discussionmentioning

confidence: 99%

Leveraging Multi-tissue, Single-Cell Atlases as Tools to Elucidate Shared Mechanisms of Immune-Mediated Inflammatory Diseases

McLean,

Reynolds,

Pratt

2024

Preprint

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The observation that certain therapeutic strategies for targeting inflammation benefit patients with distinct immune-mediated inflammatory diseases (IMIDs) is exemplified by the success of TNF blockade in conditions including rheumatoid arthritis, ulcerative colitis and skin psoriasis, albeit only for subsets of individuals with each condition. This suggests intersecting "nodes" in inflammatory networks at a molecular and cellular level may drive and/or maintain IMIDs, being “shared” between traditionally distinct diagnoses without mapping neatly to a single clinical phenotype. In line with this proposition, integrative tumour tissue analyses in oncology have highlighted novel cell states acting across diverse cancers, with important implications for precision medicine. Drawing upon advances in the oncology field, this narrative review will first summarise learnings from the Human Cell Atlas in health as a platform for interrogating IMID tissues. It will then review cross-disease studies to date that inform this endeavour, before considering future directions in the field.

show abstract

Longitudinal analysis at pre- and post-flare of T peripheral helper and T follicular helper subsets in patients with systemic lupus erythematosus

Seki,

Tsujimoto,

Tanemura

et al. 2024

Immunology Letters

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Peripheral helper T cells in human diseases

Cited by 4 publications

References 100 publications

Leveraging Multi-Tissue, Single-Cell Atlases as Tools to Elucidate Shared Mechanisms of Immune-Mediated Inflammatory Diseases

Leveraging Multi-Tissue, Single-Cell Atlases as Tools to Elucidate Shared Mechanisms of Immune-Mediated Inflammatory Diseases

Leveraging Multi-tissue, Single-Cell Atlases as Tools to Elucidate Shared Mechanisms of Immune-Mediated Inflammatory Diseases

Longitudinal analysis at pre- and post-flare of T peripheral helper and T follicular helper subsets in patients with systemic lupus erythematosus

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