Peripheral Immune Alterations in Major Depression: The Role of Subtypes and Pathogenetic Characteristics

Euteneuer, Frank; Dannehl, Katharina; Rey, Adriana del; Engler, Harald; Schedlowski, Manfred; Rief, Winfried

doi:10.3389/fpsyt.2017.00250

Cited by 48 publications

(34 citation statements)

References 47 publications

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“…NLR was related to a later onset of depression. Thus, in line with the vascular depression hypothesis as one distinct etiopathological mechanism, a later onset of depression is associated with pathological pathways relevant for cardiovascular disease has been supported 28 . Although NLR was still higher in depressed patients than healthy controls, in our analysis we could not show a significant difference.…”

Section: Discussionmentioning

confidence: 74%

Mean platelet volume and neutrophil to lymphocyte ratio decrease in patients with depression with antidepressant treatment

Öztürk

Şahan

Mirçik

et al. 2019

Arch. Clin. Psychiatry (São Paulo)

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Objective: Not only white blood cells but also platelets are being considered in inflammatory reactions from now on. Mean platelet volume (MPV) and neutrophil to lymphocyte ratio (NLR) have been shown to change in inflammatory diseases like myocardial infarction, stroke and implicated in psychiatric disorders nowadays. Our first aim is to investigate the relation of MPV and NLR with depression and secondly to assess if they change with the treatment of depression. Methods: Forty-nine patients diagnosed with major depressive disorder (MDD) and hospitalized in a university hospital psychiatry inpatient unit retrospectively included in the study. Control group consisted of 48 hospital workers with no known disease. Complete blood count, Hamilton Depression Rating Scale (HAM-D) and Clinical Global Impression-Severity Scale (CGI-S) scores at admission and at discharge were noted and compared for the patient group. Discussion: MPV of depressed patients was higher than controls. When we look at admission and discharge scores of clinical scales, decrement is statistically significant for both HAM-D and CGI-S. There was decline both in MPV and NLR which were both statistically significant. Conclusion: Decreasing MPV and NLR values with the treatment of depression confirm the involvement of inflammatory processes in the pathophysiology of depression.Öztürk A et al. / Arch Clin Psychiatry. 2019;46(1):9-13

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Section: Discussionmentioning

confidence: 74%

Mean platelet volume and neutrophil to lymphocyte ratio decrease in patients with depression with antidepressant treatment

Öztürk

Şahan

Mirçik

et al. 2019

Arch. Clin. Psychiatry (São Paulo)

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“…To date, a large number of studies have demonstrated that depression has been associated with positive regulation of interleukin-8 production and immune response (18, 50, 51). Euteneuer et al (52) revealed that patients with MDD exhibited higher neutrophil and monocyte counts and an increased neutrophil to lymphocyte ratio (NLR) than controls. They also found that lower anti-inflammatory activity was related to more severe somatic depressive symptoms.…”

Section: Mdd Major Depressive Disorder; Cns Central Nervous Systemmentioning

confidence: 99%

Identification of Key Genes and the Pathophysiology Associated With Major Depressive Disorder Patients Based on Integrated Bioinformatics Analysis

Zhang

et al. 2020

Front. Psychiatry

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Background: At present, laboratory blood tests to support major depressive disorder (MDD) diagnosis are not available. This study aimed to screen potential mRNAs for peripheral blood biomarkers and novel pathophysiology of MDD. Methods: The present study utilized public data from two mRNA microarray datasets to analyze the hub genes changes related to MDD. Gene Ontology (GO) analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis of differentially expressed genes (DEGs) were performed. Finally, some potential mRNA quality biomarkers for hub gene expression in blood were identified. Results: A total of 25 significantly co-upregulated DEGs and 98 co-downregulated DEGs were obtained from two datasets. The pathway enrichment analyses showed that co-upregulated genes were significantly enriched in the regulation of cell-matrix adhesion and mitochondrial membrane permeability which were involved in the apoptotic process. Co-downregulated genes were mainly involved in the neutrophil activation which in turn was involved in the immune response, degranulation and cell-mediated immunity, positive regulation of immune response, the Toll-like receptor signaling pathway, and the NOD-like receptor signaling pathway. From the PPI network, 14 hub genes were obtained. Among them, the subnetworks of PLCG1, BCL2A1, TLR8, FADD, and TLR4 screened out from our study have been shown to play a role in immune and inflammation responses. Discussion: The potential molecular mechanisms that have been identified simultaneously include innate immunity, neuroinflammation, and neurotrophic factors for synapse function and development.

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“…The dysregulation of the immune system as an aetiological factor, but also affecting the course of depression, is no longer questionable [32,33]. D'Acquisto [34] uses the term affective immunol- ogy.…”

Section: Emotional Immunity or Immune Emotionality? The Key To Undersmentioning

confidence: 99%

Immune to happiness – inflammatory process indicators and depressive personality traits

Talarowska¹,

Kowalczyk²,

Maes³

et al. 2020

aoms

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Introduction: Nowadays, depression is conceptualized as an immune-inflammatory and oxidative stress disorder associated with neuroprogressive changes as a consequence of peripherally activated immune-inflammatory pathways, including peripheral cytokines and immune cells which penetrate into the brain via the blood barrier, as well as nitro-oxidative stress and antioxidant imbalances. The aim of this study was to investigate whether personality traits predisposing to a depressive episode (hypochondria, dysthymic, hysteria) are associated with changes in peripheral gene expression for selected indicators of inflammation and oxidative balance. Material and methods: One hundred four people meeting the diagnostic criteria specified for a depressive episode took part in the study. Selected scales of the Minnesota Multiphasic Personality Inventory (MMPI-2) were used to measure personality traits. Expression at the mRNA and protein level for manganese superoxide dismutase (MnSOD), myeloperoxidase (MPO), cyclooxygenase 2 (COX-2), inducible nitric oxide synthase (iNOS), and metalloproteinases 2 and 9 (MMP-2, MMP-9) was examined. Results: Scales for the neurotic triad of the MMPI-2 test correlated significantly with the expression at the level of mRNA and protein for MnSOD, MPO and metalloproteinases 2 and 9. Conclusions: The scales specified for the neurotic triad of the MMPI-2 test correspond substantially with the expression of MnSOD, MPO and metalloproteinases 2 and 9 at the mRNA and protein levels in the group of patients suffering from depression.

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Peripheral Immune Alterations in Major Depression: The Role of Subtypes and Pathogenetic Characteristics

Cited by 48 publications

References 47 publications

Mean platelet volume and neutrophil to lymphocyte ratio decrease in patients with depression with antidepressant treatment

Mean platelet volume and neutrophil to lymphocyte ratio decrease in patients with depression with antidepressant treatment

Identification of Key Genes and the Pathophysiology Associated With Major Depressive Disorder Patients Based on Integrated Bioinformatics Analysis

Immune to happiness – inflammatory process indicators and depressive personality traits

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