Peripheral nerve injuries in the pediatric population: a review of the literature. Part III: peripheral nerve tumors in children

Costales, Javier Robla; Socolovsky, Mariano; Sánchez-Lázaro, J.; García, Rubén Álvarez; Costales, David Robla

doi:10.1007/s00381-018-3976-6

Cited by 9 publications

(15 citation statements)

References 47 publications

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“…The proportion of Antoni A and Antoni B areas highly varies. [ 1 3 5 ] In our case, histological findings showed a predominant Antoni A tumour. Immunohistochemistry for S-100 protein results in high distribution and intensity of staining.…”

Section: Discussionsupporting

confidence: 47%

“…In the paediatric population, schwannoma is the second-most common BPNT. [ 2 3 ] It represents 5% of all soft-tissue neurogenic tumours in children. [ 4 ] Most occur in vestibular location as non-vestibular schwannomas (NVSs) represent 1.2% of paediatric schwannoma.…”

Section: Discussionmentioning

confidence: 99%

“…Immunohistochemistry for S-100 protein results in high distribution and intensity of staining. [ 3 ] This has not been done in our case due to financial constraints.…”

Section: Discussionmentioning

confidence: 99%

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Brachial Plexus' Schwannoma in a Child

Mbaye

Seye

Zeng

et al. 2022

African Journal of Paediatric Surgery

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Children's schwannoma is a rare condition, generally occurring in a sporadic way. Its aetiology is still not fully understood. We report the case of a 10-year old girl who presented a left shoulder mass, along motility reduction of the left upper limb for 24 months before presentation at our service. A biopsy resection of the mass gave the diagnosis and 6 months after surgical resection, no complication occurred.

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Section: Discussionsupporting

confidence: 47%

Section: Discussionmentioning

confidence: 99%

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Brachial Plexus' Schwannoma in a Child

Mbaye

Seye

Zeng

et al. 2022

African Journal of Paediatric Surgery

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“…It indicates that hypoxic sEVs have the effect of prompting the activation of SC repair function ( Figure 2B ). An important component of the injury response is the activation of the immune response, which consists of the upregulation of cytokines, including IL1-β ( Costales et al, 2019 ). Elevated expression of IL-6 and TNF-α has also been demonstrated to occur early in sciatic nerve injury in rats ( Duarte-Moreira et al, 2018 ).…”

Section: Resultsmentioning

confidence: 99%

“…The average oxygen volume fraction in normal organisms is 5%, but most studies on stem cells have been carried out under normoxic (volume fraction 21% O 2 ) conditions ( Nocera and Jacob, 2020 ). Studies have shown that adipose MSCs can survive in a hypoxic environment under physiological conditions, so the cultivation of adipose MSCs under a hypoxic environment in vitro is more consistent with the in vivo environment ( Costales et al, 2019 ). Here, we investigated whether sEVs derived from umbilical cord MSCs (MSC-sEVs) can promote the repair and regeneration of PNI as a new candidate drug treatment.…”

Section: Introductionmentioning

confidence: 99%

Hypoxic culture of umbilical cord mesenchymal stem cell-derived sEVs prompts peripheral nerve injury repair

Zhu

Zhang

Huang

et al. 2023

Front. Cell. Neurosci.

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IntroductionRepair and regeneration of the peripheral nerve are important for the treatment of peripheral nerve injury (PNI) caused by mechanical tears, external compression injuries and traction injuries. Pharmacological treatment can promote the proliferation of fibroblasts and Schwann cells (SCs), which longitudinally fill the endoneurial canal and form Bungner’s band, helping the repair of peripheral nerves. Therefore, the development of new drugs for the treatment of PNI has become a top priority in recent years.MethodsHere, we report that small extracellular vesicles (sEVs) produced from umbilical cord mesenchymal stem cells (MSC-sEVs) cultured under hypoxia promote repair and regeneration of the peripheral nerve in PNI and may be a new therapeutic drug candidate.ResultsThe results showed that the amount of secreted sEVs was significantly increased in UC-MSCs compared with control cells after 48 h of culture at 3% oxygen partial pressure in a serum-free culture system. The identified MSC-sEVs could be taken up by SCs in vitro, promoting the growth and migration of SCs. In a spared nerve injury (SNI) mouse model, MSC-sEVs accelerated the recruitment of SCs at the site of PNI and promoted peripheral nerve repair and regeneration. Notably, repair and regeneration in the SNI mouse model were enhanced by treatment with hypoxic cultured UC-MSC-derived sEVs.DiscussionTherefore, we conclude that hypoxic cultured UC-MSC-derived sEVs may be a promising candidate drug for repair and regeneration in PNI.

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