2012
DOI: 10.1001/archneurol.2011.1120
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Peripheral Nerve Toxic Effects of Nitrofurantoin

Abstract: To investigate the role of skin biopsy in nitrofurantoin peripheral neuropathy. Design: We describe the clinical features and skin biopsies of 2 cases of non-length-dependent smallfiber neuropathy/ganglionopathy attributable to nitrofurantoin. Setting: Clinical evaluation and skin biopsies were performed at a tertiary teaching hospital in Baltimore, Maryland. Patients: A 59-year-old woman with disabling generalized dysesthesia and a 53-year-old woman with progressive burning pain in the perineum and extremitie… Show more

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Cited by 53 publications
(29 citation statements)
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“…Drugs and toxins Metronidazole Nitrofurantoin Linezolid Anti–TNF inhibitor Thallium Statins Chemotherapeutic agents, such as bortezomib Vaccination for rabies, varicella, or Lyme Alcohol …”
Section: Resultsmentioning
confidence: 99%
“…Drugs and toxins Metronidazole Nitrofurantoin Linezolid Anti–TNF inhibitor Thallium Statins Chemotherapeutic agents, such as bortezomib Vaccination for rabies, varicella, or Lyme Alcohol …”
Section: Resultsmentioning
confidence: 99%
“…The worldwide rise of microbial resistance to first-line antibiotic therapies has led to treatment failure, forcing physicians to shift to new classes of antimicrobial agents [5,8,24]. Antimicrobial therapy is also associated with side effects and collateral damage [11,12,13,14], and inappropriate empiric antimicrobial use drives up the costs of treatment [25,26]. …”
Section: Discussionmentioning
confidence: 99%
“…The repeated use of antibiotics has a number of additional disadvantages. Long-term (low-dose) antibiotic prophylaxis may lead to more adverse events and thus compliance problems [11,12,13,14]. Furthermore, the widespread use of antibiotics favors the increasing rates of antibiotic resistance [15].…”
Section: Introductionmentioning
confidence: 99%
“…Alcohol abuse (Koike and Sobue, 2006), statins (Lo et al, 2003), metronidazole (Tan et al, 2011), flecainide (Burakgazi et al, 2012), nitrofurantoin (Tan et al, 2012), linezolid (Chao et al, 2008), antiretroviral drugs (Ferrari and Levine, 2010), chemotherapy agents (Geber et al, 2013) Immune-mediated Sarcoidosis (Heij et al, 2012), amyloidosis (Adams et al, 2012), Sj€ ogren syndrome (Chai et al, 2005), systemic lupus erythematosus (Gøransson et al, 2006), inflammatory bowel disease (Gondim et al, 2005), celiac disease , paraneoplastic syndromes (Gorson et al, 2008) Neurodegenerative Parkinson's disease (Rossi et al, 2007), amyotrophic lateral sclerosis (Weis et al, 2011) Idiopathic Underlying cause not known, including burning mouth syndrome (Lauria et al, 2005c) with no obvious medical or dental cause. The prevalence ranges from 3.7% to 18%, with a higher prevalence in postmenopausal women (Bergdahl and Bergdahl, 1999;Grushka et al, 2002;Jääskeläinen, 2012).…”
Section: Drug and Toxic Causesmentioning
confidence: 99%