Peripheral neuropathy: A neglected cause of disability in COPD – A narrative review

Odajiu, Irina; Covanţev, Serghei; Sivapalan, Pradeesh; Mathioudakis, Alexander G.; Jensen, Jens‐Ulrik Stæhr; Davidescu, Eugenia Irene; Chatzimavridou-Grigoriadou, Victoria; Corlăteanu, Alexandru

doi:10.1016/j.rmed.2022.106952

Cited by 6 publications

(3 citation statements)

References 150 publications

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“…Chronic oxygen deprivation can lead to both central and peripheral nerve injury [ 40 ]. Patients with OSAS often have nerve dysfunction, the severity of which is partly related to the level of nocturnal hypoxemia.…”

Section: Resultsmentioning

confidence: 99%

The Burden of Comorbidities in Obstructive Sleep Apnea and the Pathophysiologic Mechanisms and Effects of CPAP

Sircu,

Colesnic,

Covantsev

et al. 2023

Clocks & Sleep

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Micro-arousals and the repeated desaturation of oxyhemoglobin, which are typical in obstructive sleep apnea syndrome (OSAS), have adverse effects on the health of patients, leading to a wide range of complications such as cardiovascular (arterial hypertension, pulmonary hypertension, chronic heart failure, arrhythmias, myocardial infarction), cerebrovascular (strokes), metabolic (insulin resistance, obesity, diabetes mellitus, metabolic syndrome), gastrointestinal (non-alcoholic liver disease), urinary (chronic renal failure), and neuropsychiatric complications as well as a wide range of malignancies. These, in turn, have multilateral effects on familial, occupational, and social life, as well as increasing the risks of road traffic accidents and accidents at the workplace. Awareness, timely screening, and the prevention of complications play important roles in diagnosing and treating comorbid conditions. This review focuses on comorbidities in OSAS and the effect of Continuous Positive Airway Pressure (CPAP) therapy on their prognoses.

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Section: Resultsmentioning

confidence: 99%

The Burden of Comorbidities in Obstructive Sleep Apnea and the Pathophysiologic Mechanisms and Effects of CPAP

Sircu,

Colesnic,

Covantsev

et al. 2023

Clocks & Sleep

Self Cite

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“…Chronic oxygen deprivation can lead to both central and peripheral nerve injury [39]. Patients with OSAS often have nerve dysfunction whose severity is partly related to the level of nocturnal hypoxemia.…”

Section: Peripheral Neuropathymentioning

confidence: 99%

Prevalence and Burden of Comorbidities in Obstructive Sleep Apnea Syndrome

Sircu,

Colesnic,

Covantsev

et al. 2023

Preprint

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Repeated desaturation of oxyhemoglobin, micro-arousals, which are typical in obstructive sleep apnea syndrome (OSAS), have negative effects on the health of patients, leading to a wide range of complications such as cardiovascular (arterial hypertension, pulmonary hypertension, chronic heart failure, arrhythmias, myocardial infarction) cerebrovascular (strokes), metabolic (insulin resistance, obesity, diabetes mellitus, metabolic syndrome), gastrointestinal (non-alcoholic liver disease), urinary (chronic renal failure), neuropsychiatric complications and a wide range of malignancies. This in turn has a multilateral effect on familial, occupational and social life, as well as increasing the risk of road traffic accidents or accidents at workplace. Awareness, timely screening and prevention of complications play an important role in the diagnosis and treatment of comorbid conditions. This review focuses on comorbidities in OSAS and the effect of CPAP therapy on their prognosis.

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“…About 5-30% of instances of neurosarcoidosis damage the cranial nerves, and the most frequent neurological symptom of sarcoidosis is peripheral facial nerves palsy, which is frequently bilateral. It happens suddenly and is typically fleeting [12]. Involvements of the central nervous systems occur in 10 to 25% of instances with sarcoidosis.…”

Section: Introductionmentioning

confidence: 99%

Clinical and pathological assessment of Peripheral neuropathy in pulmonary sarcoidosis

2023

JPTCP

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Background: Sarcoidosis is a multifactorial disorder of unfamiliar origin characterized by noncaseating granulomas in different body parts .The purpose of this investigation was to study the association of neuropathy in patients with pulmonary sarcoidosis Methods: The study included 30 patients with pulmonary sarcoidosis on systemic steroid with hypoxia, 30 patients with pulmonary sarcoidosis on systemic steroid without hypoxia and 30 patients with pulmonary sarcoidosis and not on steroid without hypoxia. Clinical, neurophysiological, laboratory, radiological and histopathological assessment was done for them. Results: LANSS pain scale was significantly associated with the neuropathic on systemic steroids contributions group when compared to the neuropathic without steroids group. The TCNS's univariate linear regression analysis revealed statistically significant correlations between clinical, electrophysiological, and disability indicators. The mean serum levels of il-2R and ACE were greater in the sick group than in the control group (193.93 ± 56.4, 202.46 ± 351.78 for patient group and 29.1 ± 8.498884, 78.526667 ± 63.995829 in control group respectively). Conclusion: There was significant positive correlation in severity of neuropathy and degree of hypoxia and there were statistically significant difference between severity of neuropathy and dose of steroids in both the Initial dosage and 3month evaluation of response.

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Peripheral neuropathy: A neglected cause of disability in COPD – A narrative review

Cited by 6 publications

References 150 publications

The Burden of Comorbidities in Obstructive Sleep Apnea and the Pathophysiologic Mechanisms and Effects of CPAP

The Burden of Comorbidities in Obstructive Sleep Apnea and the Pathophysiologic Mechanisms and Effects of CPAP

Prevalence and Burden of Comorbidities in Obstructive Sleep Apnea Syndrome

Clinical and pathological assessment of Peripheral neuropathy in pulmonary sarcoidosis

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