Peripheral Neuropathy in Systemic Autoimmune Rheumatic Diseases—Diagnosis and Treatment

Abstract

Peripheral neuropathy (PN) is frequently observed in systemic rheumatic diseases and is a challenge in clinical practice. We aimed to review the evidence on the subject and proposed a comprehensive approach to these patients, facilitating diagnosis and management. We searched the MEDLINE database for the terms (and its respective Medical Subject Headings (MeSH) terms): “peripheral neuropathy” AND “rheumatic diseases” OR “systemic lupus erythematosus”, “rheumatoid arthritis”, “Sjogren syndrome”, and “vasculitis” from 2000 to 2023. This literature review focuses on the diagnostic workup of PNs related to systemic lupus erythematosus, Sjögren’s syndrome, rheumatoid arthritis, and systemic vasculitis. For every type of PN, we provide a pragmatic flowchart for diagnosis and also describe evidence-based strategies of treatment.

Bibliometric and visualization analysis of the application of inorganic nanomaterials to autoimmune diseases

“…However, clinical laboratory testing mainly relies on manual methods, which are time-consuming and laborious, the quality of test results is difficult to guarantee, and existing automated methods also have problems of high cost and insufficient detection efficiency. 16–20 Imaging, on the other hand, assesses significant tissue damage after symptom onset, making it difficult to capture small lesions early. 21–23 In terms of treatment, autoimmune diseases are almost impossible to cure due to unknown etiology, complex pathogenesis, and individual heterogeneity.…”