Peripheral Polyfunctional PD1<sup>+</sup>CD8<sup>+</sup> T cells demonstrated strong immune protection in non‐small cell lung cancer

Liu, Yanyan; Lü, Ping; Ma, Yifei; Zhang, Yin; Xu, Hongli; Xiang, Lanxin; Zhang, Wangli; Li, Siwei; Liang, Xinjun

doi:10.1002/eji.202149570

Cited by 3 publications

(1 citation statement)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although PD-1 can be expressed on any T cell during activation, it is frequently linked to the exhaustion of CD8 + T cells and poor prognosis in numerous cancers including GC [11][12][13][14][15]. Nevertheless, several studies have demonstrated that PD-1 + CD8 + T cells play various roles in the tumor microenvironment (TME) and peripheral blood, and some of them still maintain their cytotoxic functionality [16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Early Increase in Circulating PD-1+CD8+ T Cells Predicts Favorable Survival in Patients with Advanced Gastric Cancer Receiving Chemotherapy

Shin

Kim

Park

et al. 2023

Cancers

View full text Add to dashboard Cite

The clinical significance of PD-1 expression in circulating CD8+ T cells in patients with gastric cancer (GC) receiving chemotherapy remains unelucidated. Therefore, we aimed to examine its prognostic significance in blood samples of 68 patients with advanced GC who received platinum-based chemotherapy. The correlation between peripheral blood mononuclear cells, measured using fluorescence-activated cell sorting, was evaluated. Patients were divided into two groups according to the changes in PD-1+CD8+ T-cell frequencies between day 0 and 7. They were categorized as increased or decreased PD-1+CD8+ T-cell groups. The increased PD-1+CD8+ T-cell group showed longer progression-free survival (PFS) and overall survival (OS) than the decreased PD-1+CD8+ T-cell group (PFS: 8.7 months vs. 6.1 months, p = 0.007; OS: 20.7 months vs. 10.8 months, p = 0.003). The mean duration of response was significantly different between the groups (5.7 months vs. 2.5 months, p = 0.041). Multivariate analysis revealed that an increase in PD-1+CD8+ T-cell frequency was an independent prognostic factor. We concluded that the early increase in PD-1+CD8+ T-cell frequency is a potential predictor of favorable prognoses and durable responses in patients with advanced GC receiving chemotherapy.

show abstract