Peripheral RAFT Polymerization on a Covalent Organic Polymer with Enhanced Aqueous Compatibility for Controlled Generation of Singlet Oxygen

Lai, Haiwang; Yan, Jieyu; Liu, Shan; Yang, Qizhi; Xing, Feiyue; Xiao, Pu

doi:10.1002/ange.202002446

Cited by 4 publications

(1 citation statement)

References 39 publications

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“…Organic polymer materials are synthesized by connecting organic molecular units through strong covalent bonds. , Generally, organic polymers could be divided into three categories of pristine organic polymers, functionalized organic polymers, and organic polymer composites according to different synthesis processes. For the production of pristine organic polymers, the one-pot synthesis method is commonly used for condensation and polymerization, which is relatively simple and easy to operate.…”

Section: Types Of Organic Polymersmentioning

confidence: 99%

Enrichment and Separation of Radionuclides by Organic Polymer Materials: A Review

Zhang,

Yang,

Rong

et al. 2024

ACS EST Eng.

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Nuclear power provides a chance for the decarbonization of global energyrelated emissions. However, the spent fuel produced by nuclear reactors contains various radionuclides, which require further disposal and treatment. Therefore, the enrichment and separation of radionuclides are of great significance for the recycling and utilization of resources. Organic polymer materials have attracted great attention due to their excellent physicochemical properties of rapid kinetics, high adsorption capacity, high selectivity, and diverse functionalization. This review provides an overview of the use of pristine polymers, functionalized polymers, and polymer-based composites for the highly efficient enrichment and separation of different kinds of radionuclides (i.e., U, Tc, I). The synthesis strategy, radionuclides enrichment and separation ability, and related mechanism are comprehensively summarized. The structure−property relationships in polymer-based materials that underpin their outstanding environmental remediation performance are also illustrated. Finally, the challenges and perspectives of polymer-based materials for future radionuclide separation and legacy nuclear waste management are reasonably proposed, aiming to design functional polymers for task-specific applications.

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Section: Types Of Organic Polymersmentioning

confidence: 99%

Enrichment and Separation of Radionuclides by Organic Polymer Materials: A Review

Zhang,

Yang,

Rong

et al. 2024

ACS EST Eng.

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Anthracene‐Based Endoperoxides as Self‐Sensitized Singlet Oxygen Carriers for Hypoxic‐Tumor Photodynamic Therapy

He,

Tang

2024

Adv Healthcare Materials

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Singlet oxygen is a crucial reactive oxygen species (ROS) in photodynamic therapy (PDT). However, the hypoxic tumor microenvironment limits the production of cytotoxic singlet oxygen through the light irradiation of PDT photosensitizers (PSs). This restriction poses a major challenge in improving the effectiveness of PDT. To overcome this challenge, researchers have explored the development of singlet oxygen carriers that can capture and release singlet oxygen in physiological conditions. Among these developments, anthracene‐based endoperoxides, initially discovered almost 100 years ago, have shown the ability to generate singlet oxygen controllably under thermal or photo stimuli. Recent advancements have led to the development of a new class of self‐sensitized anthracene‐endoperoxides, with potential applications in enhancing PDT effects for hypoxic tumors. This review discusses the current research progress in utilizing self‐sensitized anthracene‐endoperoxides as singlet oxygen carriers for improved PDT. It covers anthracene‐conjugated small organic molecules, metal–organic complexes, polymeric structures, and other self‐sensitized nano‐structures. The molecular structural designs, mechanisms, and characteristics of these systems will be discussed. This review aims to provide valuable insights for developing high‐performance singlet oxygen carriers for hypoxic‐tumor PDT.

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Endoperoxides Compounds for Highly Efficient Cancer Treatment under Hypoxia

Wei

Zhang

Kumar

et al. 2022

Chemistry A European J

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Photodynamic therapy (PDT) for cancer treatment has garnered tremendous attention with its promising non‐invasiveness, low side effects, and spatiotemporal selectivity. However, the hypoxic microenvironment in solid tumours remains a serious resistant factor to reducing the effects of PDT. Endoperoxides are successfully utilized as the chemical storage or supplier of singlet oxygen (1O2), the active substance for PDT in materials and other domains. Recent reports indicated that this type of compound could remarkably enhance the therapeutic effects of PDT under hypoxia. This concept mainly introduces a few representative endoperoxides and the outlook of their potent application for treating hypoxic cancer cells.

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Peripheral RAFT Polymerization on a Covalent Organic Polymer with Enhanced Aqueous Compatibility for Controlled Generation of Singlet Oxygen

Cited by 4 publications

References 39 publications

Enrichment and Separation of Radionuclides by Organic Polymer Materials: A Review

Enrichment and Separation of Radionuclides by Organic Polymer Materials: A Review

Anthracene‐Based Endoperoxides as Self‐Sensitized Singlet Oxygen Carriers for Hypoxic‐Tumor Photodynamic Therapy

Endoperoxides Compounds for Highly Efficient Cancer Treatment under Hypoxia

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