Peripheral T‐cell lymphoma in a five year old

Abstract

remission. Patients with T-LGL and myelodysplasia have a lower response rate to cyclosporine than those with T-LGL alone. Cyclophosphamide in combination with prednisone produces responses at a higher rate than prednisone alone with overall response rates of 66% and a median duration of 32 months. Growth factors such as GM-CSF or G-CSF have been used to more rapidly increase neutrophil counts in patients with severe neutropenia.While T-LGL is very uncommon in children is should be considered in the appropriate clinical setting of a patient with chronic anemia, neutropenia and/or thrombocytopenia and increased large granular lymphocytes on peripheral blood smear. The diagnosis is made by demonstrating expansion of a T-cell or NK cell population on flow cytometry along with clonal TCR gene rearrangement by molecular studies. ACKNOWLEDGMENTWe thank Rebecca H. Buckley at Duke University for performing the genetic analysis of the patient's molecular immune defect.

A rare case of peripheral T-cell lymphoma in 1-year-old child

“…[8] The role of autologous transplant is pediatric PTCL is unclear. [9] At present, treatment for PTCL NOS is unsatisfactory.…”

“…[8] The role of autologous transplant is pediatric PTCL is unclear. [9] At present, treatment for PTCL NOS is unsatisfactory. Data about PTCL from adult population suggest an inferior response to chemotherapy and poorer outcomes compared with age-and stage-matched diffuse large B-cell lymphomas (the other common aggressive lymphoma in adults), when treated with adult protocols.…”