Peripheral T-Cell Lymphoma not otherwise specified with oral manifestation: A Case Report

Abstract

Peripheral T-Cell Lymphoma Not Otherwise Specified it is a rare type of Non-Hodgkin t-cells malignant tumor whose oral manifestations are difficult to diagnose. A case of a 48-year-old male with a hemi-maxillary lesion histological and immunohistochemically compatible with Peripheral T-Cell Lymphoma not otherwise specified is presented. A case of a 48-year-old male with a hemi-maxillary lesion histological and immunohistochemically compatible with Peripheral T-Cell Lymphoma not otherwise specified is presented. The patient treatment consisted of chemotherapy, but after the second cycle, died from immunosuppressive complications. Early stage diagnosis of oral lesions is imperative to avoid aggressive treatment and low overall survival rate of such pathologies.

Peripheral T‐cell lymphoma of the oral cavity: A case report

“…It is also mentioned in the literature that PTCL commonly occurs in patients with systemic conditions like AIDS, celiac disease, Crohn's disease, rheumatoid arthritis, congenital immunodeficiency, and Sjogren's syndrome. 1 , 3 …”

“…In comparison to these studies, our case IHC was positive for CD3 and Ki67 and negative for CD20, also all the other IHC markers were negative in our case study. 2 , 3 , 13 , 14 …”

“…Chemotherapy with CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) is considered the first‐line treatment. 3 , 13 …”

“…Less than 25% of NHL tumors present on extranodal sites that commonly involve the gastrointestinal tract and less than 25% of them involve the head and neck region. 2,3 Based on previous reports, the oral cavity is involved only in 2% of cases. 1 It is uncommon for NHL to primarily presents in the oral mucosa.…”

“…Peripheral T‐cell lymphoma‐not otherwise specified (PTCL–NOS), are uncommon subtypes of NHL that arise due to inappropriate maturation of lymphoid lineage progenitor cells. 3 It has poorly defined characteristics that make its diagnosis challenging. Based on few cases in the literature, it is associated with autoimmune disease, AIDS, infections with the human T‐cell lymphotropic virus, Epstein Barr virus and human herpesvirus.…”